PTPRN_HUMAN » Receptor-type tyrosine-protein phosphatase-like N

PTPRN_HUMAN » Receptor-type tyrosine-protein phosphatase-like N
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PTPRN_HUMAN » Receptor-type tyrosine-protein phosphatase-like N » R-PTP-N; Islet cell antigen 512;ICA 512; Islet cell autoantigen 3;PTP IA-2;
Hydrophobic Thickness 36.8 ± 2.4 Å
Tilt Angle 1 ± 1°
ΔGtransfer -42.4 kcal/mol
ΔGfold -22.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 573-598 (573-605)
Pathways

Type I diabetes mellitus (KEGG)

PDB 2i1y (681-979), 3np5 (A/B/C/D=470-558), 2qt7 (A/B=468-558), 3n01 (A/B=470-558), 3n4w (A/B=470-558), 3ng8 (A/B=470-558)
OPM none
Complexes

PTPRN:PTPRN_HUMAN

Interactions

PTPRN, Complex: Homodimer of receptor-type tyrosine-protein phosphatase-like N, PDBID: 2QT7

PTPRS, Complex: PTPRN:PTPRS, PubMed

PTPRT, Complex: PTPRT:PTPRN, PubMed

Domains

AA: 60-160, RESP18 domain

AA: 469-557, PDBID: 2QT7, Subunit B, Seq Identity:100%, Protein-tyrosine phosphatase receptor IA-2

AA: 734-968, PDBID: 2I1Y, Subunit A, Seq Identity:100%, Protein-tyrosine phosphatase

UniProt annotation for PTPRN_HUMAN » Receptor-type tyrosine-protein phosphatase-like N
FUNCTION: Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2.

SUBUNIT: Interacts with phosphorylated SNTB2, protecting it from protein cleavage by CAPN1. Dephosphorylation of SNTB2 upon insulin stimulation disrupts the interaction and results in its cleavage.

TISSUE SPECIFICITY: Expression is restricted to neuroendocrine cells. Found in pancreas, brain and pituitary.

MISCELLANEOUS: Autoantigen in insulin-dependent diabetes mellitus (IDDM).

UniProt features for PTPRN_HUMAN » Receptor-type tyrosine-protein phosphatase-like N
SIGNAL 1 34 By similarity.
CHAIN 35 979 Receptor-type tyrosine-protein phosphatase-like N.
DOMAIN 709 969 Tyrosine-protein phosphatase.
REGION 909 915 Substrate binding (By similarity).
ACT_SITE 909 909 Phosphocysteine intermediate (By similarity).
SITE 448 449 Cleavage (Potential).
Amino Acid Sequence for PTPRN_HUMAN » Receptor-type tyrosine-protein phosphatase-like N
MRRPRRPGGL GGSGGLRLLL CLLLLSSRPG GCSAVSAHGC LFDRRLCSHL EVCIQDGLFG QCQVGVGQAR PLLQVTSPVL QRLQGVLRQL MSQGLSWHDD LTQYVISQEM ERIPRLRPPE PRPRDRSGLA PKRPGPAGEL LLQDIPTGSA PAAQHRLPQP PVGKGGAGAS SSLSPLQAEL LPPLLEHLLL PPQPPHPSLS YEPALLQPYL FHQFGSRDGS RVSEGSPGMV SVGPLPKAEA PALFSRTASK GIFGDHPGHS YGDLPGPSPA QLFQDSGLLY LAQELPAPSR ARVPRLPEQG SSSRAEDSPE GYEKEGLGDR GEKPASPAVQ PDAALQRLAA VLAGYGVELR QLTPEQLSTL LTLLQLLPKG AGRNPGGVVN VGADIKKTME GPVEGRDTAE LPARTSPMPG HPTASPTSSE VQQVPSPVSS EPPKAARPPV TPVLLEKKSP LGQSQPTVAG QPSARPAAEE YGYIVTDQKP LSLAAGVKLL EILAEHVHMS SGSFINISVV GPALTFRIRH NEQNLSLADV TQQAGLVKSE LEAQTGLQIL QTGVGQREEA AAVLPQTAHS TSPMRSVLLT LVALAGVAGL LVALAVALCV RQHARQQDKE RLAALGPEGA HGDTTFEYQD LCRQHMATKS LFNRAEGPPE PSRVSSVSSQ FSDAAQASPS SHSSTPSWCE EPAQANMDIS TGHMILAYME DHLRNRDRLA KEWQALCAYQ AEPNTCATAQ GEGNIKKNRH PDFLPYDHAR IKLKVESSPS RSDYINASPI IEHDPRMPAY IATQGPLSHT IADFWQMVWE SGCTVIVMLT PLVEDGVKQC DRYWPDEGAS LYHVYEVNLV SEHIWCEDFL VRSFYLKNVQ TQETRTLTQF HFLSWPAEGT PASTRPLLDF RRKVNKCYRG RSCPIIVHCS DGAGRTGTYI LIDMVLNRMA KGVKEIDIAA TLEHVRDQRP GLVRSKDQFE FALTAVAEEV NAILKALPQ