PTPRM_HUMAN » Receptor-type tyrosine-protein phosphatase mu

PTPRM_HUMAN » Receptor-type tyrosine-protein phosphatase mu
Magnify PTPRM_HUMAN » Receptor-type tyrosine-protein phosphatase muEnlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PTPRM_HUMAN » Receptor-type tyrosine-protein phosphatase mu » Protein-tyrosine phosphatase mu; R-PTP-mu;
Hydrophobic Thickness 34.0 ± 1.2 Å
Tilt Angle 0 ± 0°
ΔGtransfer -50.7 kcal/mol
ΔGfold -26.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 740-768 (738-772)
Pathways

Adherens junction (KEGG)

Cell adhesion molecules (KEGG)

PDB 2c9a (21-279), 1rpm (879-1156), 2v5y (A=21-742)
OPM none
Complexes none
Interactions

CADH1, Complex: CADH1:PTPRM, PubMed

PCSK5, Complex: PTPRM:PCSK5, PubMed

PTPRA, Complex: PTPRM:PTPRA, PubMed

PTPRK, Complex: PTPRM:PTPRK, PubMed

PTPRS, Complex: PTPRS:PTPRM, PubMed

Domains

AA: 27-183, PDBID: 2C9A, Subunit A, Seq Identity:100%, MAM domain, meprin/A5/mu

AA: 189-274, PDBID: 2C9A, Subunit A, Seq Identity:100%, Immunoglobulin domain

AA: 283-366, PDBID: 2V5Y, Subunit A, Seq Identity:100%, Fibronectin type III domain

AA: 488-575, PDBID: 2V5Y, Subunit A, Seq Identity:100%, Fibronectin type III domain

AA: 923-1153, PDBID: 1RPM, Subunit A, Seq Identity:100%, Protein-tyrosine phosphatase

AA: 1213-1447, PDBID: 3SR9, Subunit A, Seq Identity:41%, Protein-tyrosine phosphatase

UniProt annotation for PTPRM_HUMAN » Receptor-type tyrosine-protein phosphatase mu
FUNCTION: Involved in cell-cell adhesion through homophilic interactions. May play a key role in signal transduction and growth control.

CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.

UniProt features for PTPRM_HUMAN » Receptor-type tyrosine-protein phosphatase mu
SIGNAL 1 20 Potential.
CHAIN 21 1452 Receptor-type tyrosine-protein phosphatase mu.
DOMAIN 22 184 MAM.
DOMAIN 186 277 Ig-like C2-type.
DOMAIN 281 371 Fibronectin type-III 1.
DOMAIN 379 477 Fibronectin type-III 2.
DOMAIN 482 581 Fibronectin type-III 3.
DOMAIN 589 671 Fibronectin type-III 4.
DOMAIN 900 1154 Tyrosine-protein phosphatase 1.
DOMAIN 1186 1448 Tyrosine-protein phosphatase 2.
REGION 1095 1101 Substrate binding (By similarity).
ACT_SITE 1095 1095 Phosphocysteine intermediate (By similarity).
ACT_SITE 1389 1389 Phosphocysteine intermediate (By similarity).
DISULFID 27 36
DISULFID 96 182
DISULFID 206 260
Amino Acid Sequence for PTPRM_HUMAN » Receptor-type tyrosine-protein phosphatase mu
MRGLGTCLAT LAGLLLTAAG ETFSGGCLFD EPYSTCGYSQ SEGDDFNWEQ VNTLTKPTSD PWMPSGSFML VNASGRPEGQ RAHLLLPQLK ENDTHCIDFH YFVSSKSNSP PGLLNVYVKV NNGPLGNPIW NISGDPTRTW NRAELAISTF WPNFYQVIFE VITSGHQGYL AIDEVKVLGH PCTRTPHFLR IQNVEVNAGQ FATFQCSAIG RTVAGDRLWL QGIDVRDAPL KEIKVTSSRR FIASFNVVNT TKRDAGKYRC MIRTEGGVGI SNYAELVVKE PPVPIAPPQL ASVGATYLWI QLNANSINGD GPIVAREVEY CTASGSWNDR QPVDSTSYKI GHLDPDTEYE ISVLLTRPGE GGTGSPGPAL RTRTKCADPM RGPRKLEVVE VKSRQITIRW EPFGYNVTRC HSYNLTVHYC YQVGGQEQVR EEVSWDTENS HPQHTITNLS PYTNVSVKLI LMNPEGRKES QELIVQTDED LPGAVPTESI QGSTFEEKIF LQWREPTQTY GVITLYEITY KAVSSFDPEI DLSNQSGRVS KLGNETHFLF FGLYPGTTYS FTIRASTAKG FGPPATNQFT TKISAPSMPA YELETPLNQT DNTVTVMLKP AHSRGAPVSV YQIVVEEERP RRTKKTTEIL KCYPVPIHFQ NASLLNSQYY FAAEFPADSL QAAQPFTIGD NKTYNGYWNT PLLPYKSYRI YFQAASRANG ETKIDCVQVA TKGAATPKPV PEPEKQTDHT VKIAGVIAGI LLFVIIFLGV VLVMKKRKLA KKRKETMSST RQEMTVMVNS MDKSYAEQGT NCDEAFSFMD THNLNGRSVS SPSSFTMKTN TLSTSVPNSY YPDETHTMAS DTSSLVQSHT YKKREPADVP YQTGQLHPAI RVADLLQHIT QMKCAEGYGF KEEYESFFEG QSAPWDSAKK DENRMKNRYG NIIAYDHSRV RLQTIEGDTN SDYINGNYID GYHRPNHYIA TQGPMQETIY DFWRMVWHEN TASIIMVTNL VEVGRVKCCK YWPDDTEIYK DIKVTLIETE LLAEYVIRTF AVEKRGVHEI REIRQFHFTG WPDHGVPYHA TGLLGFVRQV KSKSPPSAGP LVVHCSAGAG RTGCFIVIDI MLDMAEREGV VDIYNCVREL RSRRVNMVQT EEQYVFIHDA ILEACLCGDT SVPASQVRSL YYDMNKLDPQ TNSSQIKEEF RTLNMVTPTL RVEDCSIALL PRNHEKNRCM DILPPDRCLP FLITIDGESS NYINAALMDS YKQPSAFIVT QHPLPNTVKD FWRLVLDYHC TSVVMLNDVD PAQLCPQYWP ENGVHRHGPI QVEFVSADLE EDIISRIFRI YNAARPQDGY RMVQQFQFLG WPMYRDTPVS KRSFLKLIRQ VDKWQEEYNG GEGRTVVHCL NGGGRSGTFC AISIVCEMLR HQRTVDVFHA VKTLRNNKPN MVDLLDQYKF CYEVALEYLN SG