PTPRK_HUMAN » Receptor-type tyrosine-protein phosphatase kappa

PTPRK_HUMAN » Receptor-type tyrosine-protein phosphatase kappa
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PTPRK_HUMAN » Receptor-type tyrosine-protein phosphatase kappa » Protein-tyrosine phosphatase kappa; R-PTP-kappa;
Hydrophobic Thickness 28.8 ± 1.2 Å
Tilt Angle 0 ± 1°
ΔGtransfer -45.2 kcal/mol
ΔGfold -26.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 754-776 (748-782)
Pathways none
PDB 2c7s (865-1154)
OPM none
Complexes none
Interactions

ALK, Complex: ALK:PTPRK, PubMed

CADH2, Complex: CADH2:PTPRK

ERBB2, Complex: PTPRK:ERBB2

FKBP8, Complex: PTPRK:FKBP8, PubMed

GHR, Complex: GHR:PTPRK

INSR, Complex: PTPRK:INSR

MET, Complex: PTPRK:MET

PGFRB, Complex: PTPRK:PGFRB

PTPRM, Complex: PTPRM:PTPRK, PubMed

TIE2, Complex: PTPRK:TIE2

Domains

AA: 36-193, PDBID: 2C9A, Subunit A, Seq Identity:51%, MAM domain, meprin/A5/mu

AA: 197-288, PDBID: 1RHF, Subunit B, Seq Identity:28%, Immunoglobulin I-set domain

AA: 292-376, PDBID: 2V5Y, Subunit A, Seq Identity:73%, Fibronectin type III domain

AA: 493-583, PDBID: 2V5Y, Subunit A, Seq Identity:54%, Fibronectin type III domain

AA: 910-1140, PDBID: 2C7S, Subunit A, Seq Identity:100%, Protein-tyrosine phosphatase

AA: 1200-1434, PDBID: 2JJD, Subunit D, Seq Identity:41%, Protein-tyrosine phosphatase

UniProt annotation for PTPRK_HUMAN » Receptor-type tyrosine-protein phosphatase kappa
FUNCTION: Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa.

CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.

TISSUE SPECIFICITY: High levels in lung, brain and colon; less in liver, pancreas, stomach, kidney, placenta and mammary carcinoma.

UniProt features for PTPRK_HUMAN » Receptor-type tyrosine-protein phosphatase kappa
SIGNAL 1 26 Potential.
CHAIN 27 1439 Receptor-type tyrosine-protein phosphatase kappa.
DOMAIN 31 194 MAM.
DOMAIN 196 281 Ig-like C2-type.
DOMAIN 291 383 Fibronectin type-III 1.
DOMAIN 389 485 Fibronectin type-III 2.
DOMAIN 490 589 Fibronectin type-III 3.
DOMAIN 597 680 Fibronectin type-III 4.
DOMAIN 887 1141 Tyrosine-protein phosphatase 1.
DOMAIN 1173 1435 Tyrosine-protein phosphatase 2.
REGION 1082 1088 Substrate binding (By similarity).
ACT_SITE 1082 1082 Phosphocysteine intermediate (By similarity).
ACT_SITE 1376 1376 Phosphocysteine intermediate (By similarity).
SITE 643 644 Cleavage (Probable).
DISULFID 216 270 Potential.
Amino Acid Sequence for PTPRK_HUMAN » Receptor-type tyrosine-protein phosphatase kappa
MDTTAAAALP AFVALLLLSP WPLLGSAQGQ FSAGGCTFDD GPGACDYHQD LYDDFEWVHV SAQEPHYLPP EMPQGSYMIV DSSDHDPGEK ARLQLPTMKE NDTHCIDFSY LLYSQKGLNP GTLNILVRVN KGPLANPIWN VTGFTGRDWL RAELAVSTFW PNEYQVIFEA EVSGGRSGYI AIDDIQVLSY PCDKSPHFLR LGDVEVNAGQ NATFQCIATG RDAVHNKLWL QRRNGEDIPV AQTKNINHRR FAASFRLQEV TKTDQDLYRC VTQSERGSGV SNFAQLIVRE PPRPIAPPQL LGVGPTYLLI QLNANSIIGD GPIILKEVEY RMTSGSWTET HAVNAPTYKL WHLDPDTEYE IRVLLTRPGE GGTGLPGPPL ITRTKCAEPM RTPKTLKIAE IQARRIAVDW ESLGYNITRC HTFNVTICYH YFRGHNESKA DCLDMDPKAP QHVVNHLPPY TNVSLKMILT NPEGRKESEE TIIQTDEDVP GPVPVKSLQG TSFENKIFLN WKEPLDPNGI ITQYEISYSS IRSFDPAVPV AGPPQTVSNL WNSTHHVFMH LHPGTTYQFF IRASTVKGFG PATAINVTTN ISAPTLPDYE GVDASLNETA TTITVLLRPA QAKGAPISAY QIVVEELHPH RTKREAGAME CYQVPVTYQN AMSGGAPYYF AAELPPGNLP EPAPFTVGDN RTYQGFWNPP LAPRKGYNIY FQAMSSVEKE TKTQCVRIAT KAATEEPEVI PDPAKQTDRV VKIAGISAGI LVFILLLLVV ILIVKKSKLA KKRKDAMGNT RQEMTHMVNA MDRSYADQST LHAEDPLSIT FMDQHNFSPR YENHSATAES SRLLDVPRYL CEGTESPYQT GQLHPAIRVA DLLQHINLMK TSDSYGFKEE YESFFEGQSA SWDVAKKDQN RAKNRYGNII AYDHSRVILQ PVEDDPSSDY INANYIDGYQ RPSHYIATQG PVHETVYDFW RMIWQEQSAC IVMVTNLVEV GRVKCYKYWP DDTEVYGDFK VTCVEMEPLA EYVVRTFTLE RRGYNEIREV KQFHFTGWPD HGVPYHATGL LSFIRRVKLS NPPSAGPIVV HCSAGAGRTG CYIVIDIMLD MAEREGVVDI YNCVKALRSR RINMVQTEEQ YIFIHDAILE ACLCGETAIP VCEFKAAYFD MIRIDSQTNS SHLKDEFQTL NSVTPRLQAE DCSIACLPRN HDKNRFMDML PPDRCLPFLI TIDGESSNYI NAALMDSYRQ PAAFIVTQYP LPNTVKDFWR LVYDYGCTSI VMLNEVDLSQ GCPQYWPEEG MLRYGPIQVE CMSCSMDCDV INRIFRICNL TRPQEGYLMV QQFQYLGWAS HREVPGSKRS FLKLILQVEK WQEECEEGEG RTIIHCLNGG GRSGMFCAIG IVVEMVKRQN VVDVFHAVKT LRNSKPNMVE APEQYRFCYD VALEYLESS