PTPRG_HUMAN » Receptor-type tyrosine-protein phosphatase gamma

PTPRG_HUMAN » Receptor-type tyrosine-protein phosphatase gamma
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PTPRG_HUMAN » Receptor-type tyrosine-protein phosphatase gamma » Protein-tyrosine phosphatase gamma; R-PTP-gamma;
Hydrophobic Thickness 35.6 ± 1.4 Å
Tilt Angle 0 ± 0°
ΔGtransfer -48.5 kcal/mol
ΔGfold -26.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 734-763 (734-765)
Pathways none
PDB 3jxh (56-320), 2hy3 (820-1130), 2pbn (820-1130), 3qcn (825-1128), 3qci (825-1128), 3qcj (825-1128), 3qck (825-1128), 3qcl (825-1128), 3qcm (825-1128), 3qch (825-1128), 3qcg (825-1128), 3qcf (825-1128), 3qce (825-1128), 3qcd (825-1128), 3qcc (825-1128), 3qcb (825-1128), 2nlk (827-1445), 2h4v (831-1127)
OPM none
Complexes none
Interactions

ALK, Complex: ALK:PTPRG

CADH2, Complex: CADH2:PTPRG, PubMed

EPOR, Complex: EPOR:PTPRG

ERBB2, Complex: PTPRG:ERBB2, PubMed

INSR, Complex: INSR:PTPRG

MET, Complex: MET:PTPRG

NTRK1, Complex: NTRK1:PTPRG

PGFRB, Complex: PGFRB:PTPRG

TIE1, Complex: PTPRG:TIE1, PubMed

TIE2, Complex: TIE2:PTPRG, PubMed

Domains

AA: 59-320, PDBID: 3JXH, Subunit C, Seq Identity:100%, Eukaryotic-type carbonic anhydrase

AA: 348-436, PDBID: 2N1K, Subunit A, Seq Identity:26%, Fibronectin type III domain

AA: 874-1118, PDBID: 2H4V, Subunit B, Seq Identity:100%, Protein-tyrosine phosphatase

AA: 1175-1409, PDBID: 2NLK, Subunit A, Seq Identity:100%, Protein-tyrosine phosphatase

UniProt annotation for PTPRG_HUMAN » Receptor-type tyrosine-protein phosphatase gamma
FUNCTION: Possesses tyrosine phosphatase activity.

CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.

SUBUNIT: Monomer; active form. Homodimer; inactive form (Probable). Interacts with CNTN3, CNTN4, CNTN5 and CNTN6.

TISSUE SPECIFICITY: Found in a variety of tissues.

UniProt features for PTPRG_HUMAN » Receptor-type tyrosine-protein phosphatase gamma
SIGNAL 1 19
CHAIN 20 1445 Receptor-type tyrosine-protein phosphatase gamma.
DOMAIN 58 321 Alpha-carbonic anhydrase.
DOMAIN 346 443 Fibronectin type-III.
DOMAIN 848 1119 Tyrosine-protein phosphatase 1.
DOMAIN 1150 1410 Tyrosine-protein phosphatase 2.
REGION 1060 1066 Substrate binding (By similarity).
ACT_SITE 1060 1060 Phosphocysteine intermediate (By similarity).
SITE 1351 1351 Ancestral active site.
Amino Acid Sequence for PTPRG_HUMAN » Receptor-type tyrosine-protein phosphatase gamma
MRRLLEPCWW ILFLKITSSV LHYVVCFPAL TEGYVGALHE NRHGSAVQIR RRKASGDPYW AYSGAYGPEH WVTSSVSCGG RHQSPIDILD QYARVGEEYQ ELQLDGFDNE SSNKTWMKNT GKTVAILLKD DYFVSGAGLP GRFKAEKVEF HWGHSNGSAG SEHSINGRRF PVEMQIFFYN PDDFDSFQTA ISENRIIGAM AIFFQVSPRD NSALDPIIHG LKGVVHHEKE TFLDPFVLRD LLPASLGSYY RYTGSLTTPP CSEIVEWIVF RRPVPISYHQ LEAFYSIFTT EQQDHVKSVE YLRNNFRPQQ RLHDRVVSKS AVRDSWNHDM TDFLENPLGT EASKVCSSPP IHMKVQPLNQ TALQVSWSQP ETIYHPPIMN YMISYSWTKN EDEKEKTFTK DSDKDLKATI SHVSPDSLYL FRVQAVCRND MRSDFSQTML FQANTTRIFQ GTRIVKTGVP TASPASSADM APISSGSSTW TSSGIPFSFV SMATGMGPSS SGSQATVASV VTSTLLAGLG FGGGGISSFP STVWPTRLPT AASASKQAAR PVLATTEALA SPGPDGDSSP TKDGEGTEEG EKDEKSESED GEREHEEDGE KDSEKKEKSG VTHAAEERNQ TEPSPTPSSP NRTAEGGHQT IPGHEQDHTA VPTDQTGGRR DAGPGLDPDM VTSTQVPPTA TEEQYAGSDP KRPEMPSKKP MSRGDRFSED SRFITVNPAE KNTSGMISRP APGRMEWIIP LIVVSALTFV CLILLIAVLV YWRGCNKIKS KGFPRRFREV PSSGERGEKG SRKCFQTAHF YVEDSSSPRV VPNESIPIIP IPDDMEAIPV KQFVKHIGEL YSNNQHGFSE DFEEVQRCTA DMNITAEHSN HPENKHKNRY INILAYDHSR VKLRPLPGKD SKHSDYINAN YVDGYNKAKA YIATQGPLKS TFEDFWRMIW EQNTGIIVMI TNLVEKGRRK CDQYWPTENS EEYGNIIVTL KSTKIHACYT VRRFSIRNTK VKKGQKGNPK GRQNERVVIQ YHYTQWPDMG VPEYALPVLT FVRRSSAARM PETGPVLVHC SAGVGRTGTY IVIDSMLQQI KDKSTVNVLG FLKHIRTQRN YLVQTEEQYI FIHDALLEAI LGKETEVSSN QLHSYVNSIL IPGVGGKTRL EKQFKLVTQC NAKYVECFSA QKECNKEKNR NSSVVPSERA RVGLAPLPGM KGTDYINASY IMGYYRSNEF IITQHPLPHT TKDFWRMIWD HNAQIIVMLP DNQSLAEDEF VYWPSREESM NCEAFTVTLI SKDRLCLSNE EQIIIHDFIL EATQDDYVLE VRHFQCPKWP NPDAPISSTF ELINVIKEEA LTRDGPTIVH DEYGAVSAGM LCALTTLSQQ LENENAVDVF QVAKMINLMR PGVFTDIEQY QFIYKAMLSL VSTKENGNGP MTVDKNGAVL IADESDPAES MESLV