PTPRF_HUMAN » Receptor-type tyrosine-protein phosphatase F

PTPRF_HUMAN » Receptor-type tyrosine-protein phosphatase F
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PTPRF_HUMAN » Receptor-type tyrosine-protein phosphatase F » Leukocyte common antigen related;LAR;
Hydrophobic Thickness 37.2 ± 1.6 Å
Tilt Angle 0 ± 0°
ΔGtransfer -59.0 kcal/mol
ΔGfold -27.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 1261-1285 (1259-1288)
Pathways

Adherens junction (KEGG)

Cell adhesion molecules (KEGG)

Insulin signaling pathway (KEGG)

PDB 1lar (1333-1907), 2yd5 (29-231), 2yd8 (29-231), 2dju (319-411), 2edx (596-716), 4n5u (601-705), 2dn7 (821-914), 2edy (915-1010)
OPM none
Complexes none
Interactions

CADH1, Complex: PTPRF:CADH1, PubMed

EGFR, Complex: PTPRF:EGFR, PubMed

GALT1, Complex: PTPRF:GALT1, PubMed

INSR, Complex: PTPRF:INSR, PubMed

PTPRA, Complex: PTPRA:PTPRF, PubMed

PTPRD, Complex: PTPRD:PTPRF, PubMed

RET, Complex: RET:PTPRF, PubMed

RYK, Complex: PTPRF:RYK, PubMed

Domains

AA: 33-124, PDBID: 2YD5, Subunit A, Seq Identity:100%, Immunoglobulin I-set domain

AA: 135-225, PDBID: 2YD5, Subunit A, Seq Identity:100%, Immunoglobulin I-set domain

AA: 232-315, PDBID: 2YD9, Subunit A, Seq Identity:75%, Immunoglobulin I-set domain

AA: 320-401, PDBID: 2DJU, Subunit A, Seq Identity:100%, Fibronectin type III domain

AA: 415-500, PDBID: 4PBX, Subunit A, Seq Identity:70%, Fibronectin type III domain

AA: 513-594, PDBID: 1X5Z, Subunit A, Seq Identity:51%, Fibronectin type III domain

AA: 608-696, PDBID: 2EDX, Subunit A, Seq Identity:100%, Fibronectin type III domain

AA: 710-809, PDBID: 2DLH, Subunit A, Seq Identity:33%, Fibronectin type III domain

AA: 823-903, PDBID: 2DB8, Subunit A, Seq Identity:33%, Fibronectin type III domain

AA: 917-1000, PDBID: 2EDY, Subunit A, Seq Identity:100%, Fibronectin type III domain

AA: 1375-1606, PDBID: 1LAR, Subunit A, Seq Identity:100%, Protein-tyrosine phosphatase

AA: 1664-1897, PDBID: 1LAR, Subunit A, Seq Identity:100%, Protein-tyrosine phosphatase

UniProt annotation for PTPRF_HUMAN » Receptor-type tyrosine-protein phosphatase F
FUNCTION: Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity.

FUNCTION: The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.

CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.

SUBUNIT: Interacts with GRIP1 (By similarity). Interacts with PPFIA1, PPFIA2 and PPFIA3. Interacts with INSR.

DISEASE: Aplasia or hypoplasia of the breasts and/or nipples 2 (BNAH2) OMIM: A group of congenital deformities encompassing total absence of breasts and nipple (amastia), absence of the nipple (athelia), and absence of the mammary gland (amazia). caused by mutations affecting the gene represented in this entry.

UniProt features for PTPRF_HUMAN » Receptor-type tyrosine-protein phosphatase F
SIGNAL 1 29 Potential.
CHAIN 30 1907 Receptor-type tyrosine-protein phosphatase F.
DOMAIN 33 123 Ig-like C2-type 1.
DOMAIN 135 224 Ig-like C2-type 2.
DOMAIN 232 314 Ig-like C2-type 3.
DOMAIN 319 407 Fibronectin type-III 1.
DOMAIN 413 506 Fibronectin type-III 2.
DOMAIN 512 602 Fibronectin type-III 3.
DOMAIN 606 703 Fibronectin type-III 4.
DOMAIN 708 815 Fibronectin type-III 5.
DOMAIN 817 910 Fibronectin type-III 6.
DOMAIN 915 1008 Fibronectin type-III 7.
DOMAIN 1011 1095 Fibronectin type-III 8.
DOMAIN 1352 1607 Tyrosine-protein phosphatase 1.
DOMAIN 1639 1898 Tyrosine-protein phosphatase 2.
REGION 68 77 Heparin-binding (By similarity).
REGION 1548 1554 Substrate binding (By similarity).
ACT_SITE 1548 1548 Phosphocysteine intermediate (Probable).
ACT_SITE 1839 1839 Phosphocysteine intermediate (By similarity).
DISULFID 54 107 By similarity.
DISULFID 156 207 By similarity.
DISULFID 253 298 By similarity.
Amino Acid Sequence for PTPRF_HUMAN » Receptor-type tyrosine-protein phosphatase F
MAPEPAPGRT MVPLVPALVM LGLVAGAHGD SKPVFIKVPE DQTGLSGGVA SFVCQATGEP KPRITWMKKG KKVSSQRFEV IEFDDGAGSV LRIQPLRVQR DEAIYECTAT NSLGEINTSA KLSVLEEEQL PPGFPSIDMG PQLKVVEKAR TATMLCAAGG NPDPEISWFK DFLPVDPATS NGRIKQLRSG ALQIESSEES DQGKYECVAT NSAGTRYSAP ANLYVRVRRV APRFSIPPSS QEVMPGGSVN LTCVAVGAPM PYVKWMMGAE ELTKEDEMPV GRNVLELSNV VRSANYTCVA ISSLGMIEAT AQVTVKALPK PPIDLVVTET TATSVTLTWD SGNSEPVTYY GIQYRAAGTE GPFQEVDGVA TTRYSIGGLS PFSEYAFRVL AVNSIGRGPP SEAVRARTGE QAPSSPPRRV QARMLSASTM LVQWEPPEEP NGLVRGYRVY YTPDSRRPPN AWHKHNTDAG LLTTVGSLLP GITYSLRVLA FTAVGDGPPS PTIQVKTQQG VPAQPADFQA EVESDTRIQL SWLLPPQERI IMYELVYWAA EDEDQQHKVT FDPTSSYTLE DLKPDTLYRF QLAARSDMGV GVFTPTIEAR TAQSTPSAPP QKVMCVSMGS TTVRVSWVPP PADSRNGVIT QYSVAYEAVD GEDRGRHVVD GISREHSSWD LVGLEKWTEY RVWVRAHTDV GPGPESSPVL VRTDEDVPSG PPRKVEVEPL NSTAVHVYWK LPVPSKQHGQ IRGYQVTYVR LENGEPRGLP IIQDVMLAEA QWRPEESEDY ETTISGLTPE TTYSVTVAAY TTKGDGARSK PKIVTTTGAV PGRPTMMIST TAMNTALLQW HPPKELPGEL LGYRLQYCRA DEARPNTIDF GKDDQHFTVT GLHKGTTYIF RLAAKNRAGL GEEFEKEIRT PEDLPSGFPQ NLHVTGLTTS TTELAWDPPV LAERNGRIIS YTVVFRDINS QQELQNITTD TRFTLTGLKP DTTYDIKVRA WTSKGSGPLS PSIQSRTMPV EQVFAKNFRV AAAMKTSVLL SWEVPDSYKS AVPFKILYNG QSVEVDGHSM RKLIADLQPN TEYSFVLMNR GSSAGGLQHL VSIRTAPDLL PHKPLPASAY IEDGRFDLSM PHVQDPSLVR WFYIVVVPID RVGGSMLTPR WSTPEELELD ELLEAIEQGG EEQRRRRRQA ERLKPYVAAQ LDVLPETFTL GDKKNYRGFY NRPLSPDLSY QCFVLASLKE PMDQKRYASS PYSDEIVVQV TPAQQQEEPE MLWVTGPVLA VILIILIVIA ILLFKRKRTH SPSSKDEQSI GLKDSLLAHS SDPVEMRRLN YQTPGMRDHP PIPITDLADN IERLKANDGL KFSQEYESID PGQQFTWENS NLEVNKPKNR YANVIAYDHS RVILTSIDGV PGSDYINANY IDGYRKQNAY IATQGPLPET MGDFWRMVWE QRTATVVMMT RLEEKSRVKC DQYWPARGTE TCGLIQVTLL DTVELATYTV RTFALHKSGS SEKRELRQFQ FMAWPDHGVP EYPTPILAFL RRVKACNPLD AGPMVVHCSA GVGRTGCFIV IDAMLERMKH EKTVDIYGHV TCMRSQRNYM VQTEDQYVFI HEALLEAATC GHTEVPARNL YAHIQKLGQV PPGESVTAME LEFKLLASSK AHTSRFISAN LPCNKFKNRL VNIMPYELTR VCLQPIRGVE GSDYINASFL DGYRQQKAYI ATQGPLAEST EDFWRMLWEH NSTIIVMLTK LREMGREKCH QYWPAERSAR YQYFVVDPMA EYNMPQYILR EFKVTDARDG QSRTIRQFQF TDWPEQGVPK TGEGFIDFIG QVHKTKEQFG QDGPITVHCS AGVGRTGVFI TLSIVLERMR YEGVVDMFQT VKTLRTQRPA MVQTEDQYQL CYRAALEYLG SFDHYAT