PTPRD_HUMAN » Receptor-type tyrosine-protein phosphatase delta

PTPRD_HUMAN » Receptor-type tyrosine-protein phosphatase delta
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PTPRD_HUMAN » Receptor-type tyrosine-protein phosphatase delta » Protein-tyrosine phosphatase delta; R-PTP-delta;
Hydrophobic Thickness 33.6 ± 2.2 Å
Tilt Angle 2 ± 0°
ΔGtransfer -54.6 kcal/mol
ΔGfold -27.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 1266-1291 (1262-1296)
Pathways none
PDB 2yd7 (21-226), 2dlh (407-514), 1x5z (506-607), 2yd6 (A=21-226), 4rca (A=21-322)
OPM none
Complexes

PTPRD:SLIK1_HUMAN

Interactions

EGFR, Complex: PTPRD:EGFR, PubMed

PTPRA, Complex: PTPRD:PTPRA, PubMed

PTPRE, Complex: PTPRE:PTPRD, PubMed

PTPRF, Complex: PTPRD:PTPRF, PubMed

PTPRS, Complex: PTPRS:PTPRD, PubMed

SLIK1, Complex: PTPRD:SLIK1, PDBID: 4RCA

Domains

AA: 24-115, PDBID: 2YD6, Subunit A, Seq Identity:100%, Immunoglobulin I-set domain

AA: 126-225, PDBID: 2YD6, Subunit A, Seq Identity:100%, Immunoglobulin I-set domain

AA: 235-306, PDBID: 4RCA, Subunit A, Seq Identity:100%, Immunoglobulin domain

AA: 324-405, PDBID: 4Y61, Subunit A, Seq Identity:96%, Fibronectin type III domain

AA: 419-504, PDBID: 2DLH, Subunit A, Seq Identity:100%, Fibronectin type III domain

AA: 517-597, PDBID: 1X5Z, Subunit A, Seq Identity:100%, Fibronectin type III domain

AA: 611-699, PDBID: 2EDX, Subunit A, Seq Identity:58%, Fibronectin type III domain

AA: 713-812, PDBID: 2ED9, Subunit A, Seq Identity:29%, Fibronectin type III domain

AA: 825-907, PDBID: 1WF5, Subunit A, Seq Identity:29%, Fibronectin type III domain

AA: 920-1006, PDBID: 2EDY, Subunit A, Seq Identity:62%, Fibronectin type III domain

AA: 1380-1611, PDBID: 1LAR, Subunit A, Seq Identity:86%, Protein-tyrosine phosphatase

AA: 1669-1902, PDBID: 2FH7, Subunit A, Seq Identity:98%, Protein-tyrosine phosphatase

UniProt annotation for PTPRD_HUMAN » Receptor-type tyrosine-protein phosphatase delta
CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.

SUBUNIT: Interacts with IL1RAPL1 (via extracellular region); interaction is required for IL1RAPL1-mediated synapse formation (By similarity). Interacts with PPFIA1, PPFIA2 and PPFIA3.

UniProt features for PTPRD_HUMAN » Receptor-type tyrosine-protein phosphatase delta
SIGNAL 1 20 Potential.
CHAIN 21 1912 Receptor-type tyrosine-protein phosphatase delta.
DOMAIN 24 114 Ig-like C2-type 1.
DOMAIN 126 224 Ig-like C2-type 2.
DOMAIN 236 318 Ig-like C2-type 3.
DOMAIN 323 411 Fibronectin type-III 1.
DOMAIN 417 511 Fibronectin type-III 2.
DOMAIN 516 604 Fibronectin type-III 3.
DOMAIN 609 706 Fibronectin type-III 4.
DOMAIN 711 819 Fibronectin type-III 5.
DOMAIN 824 913 Fibronectin type-III 6.
DOMAIN 918 1013 Fibronectin type-III 7.
DOMAIN 1017 1103 Fibronectin type-III 8.
DOMAIN 1357 1612 Tyrosine-protein phosphatase 1.
DOMAIN 1644 1903 Tyrosine-protein phosphatase 2.
REGION 180 189 Interaction with IL1RAPL1 (By similarity).
REGION 1553 1559 Substrate binding (By similarity).
ACT_SITE 1553 1553 Phosphocysteine intermediate (By similarity).
ACT_SITE 1844 1844 Phosphocysteine intermediate (By similarity).
SITE 1181 1182 Cleavage (Probable).
DISULFID 45 98 Potential.
DISULFID 147 207 Potential.
DISULFID 257 302 Potential.
Amino Acid Sequence for PTPRD_HUMAN » Receptor-type tyrosine-protein phosphatase delta
MVHVARLLLL LLTFFLRTDA ETPPRFTRTP VDQTGVSGGV ASFICQATGD PRPKIVWNKK GKKVSNQRFE VIEFDDGSGS VLRIQPLRTP RDEAIYECVA SNNVGEISVS TRLTVLREDQ IPRGFPTIDM GPQLKVVERT RTATMLCAAS GNPDPEITWF KDFLPVDTSN NNGRIKQLRS ESIGGTPIRG ALQIEQSEES DQGKYECVAT NSAGTRYSAP ANLYVRELRE VRRVPPRFSI PPTNHEIMPG GSVNITCVAV GSPMPYVKWM LGAEDLTPED DMPIGRNVLE LNDVRQSANY TCVAMSTLGV IEAIAQITVK ALPKPPGTPV VTESTATSIT LTWDSGNPEP VSYYIIQHKP KNSEELYKEI DGVATTRYSV AGLSPYSDYE FRVVAVNNIG RGPPSEPVLT QTSEQAPSSA PRDVQARMLS STTILVQWKE PEEPNGQIQG YRVYYTMDPT QHVNNWMKHN VADSQITTIG NLVPQKTYSV KVLAFTSIGD GPLSSDIQVI TQTGVPGQPL NFKAEPESET SILLSWTPPR SDTIANYELV YKDGEHGEEQ RITIEPGTSY RLQGLKPNSL YYFRLAARSP QGLGASTAEI SARTMQSKPS APPQDISCTS PSSTSILVSW QPPPVEKQNG IITEYSIKYT AVDGEDDKPH EILGIPSDTT KYLLEQLEKW TEYRITVTAH TDVGPGPESL SVLIRTNEDV PSGPPRKVEV EAVNSTSVKV SWRSPVPNKQ HGQIRGYQVH YVRMENGEPK GQPMLKDVML ADAQWEFDDT TEHDMIISGL QPETSYSLTV TAYTTKGDGA RSKPKLVSTT GAVPGKPRLV INHTQMNTAL IQWHPPVDTF GPLQGYRLKF GRKDMEPLTT LEFSEKEDHF TATDIHKGAS YVFRLSARNK VGFGEEMVKE ISIPEEVPTG FPQNLHSEGT TSTSVQLSWQ PPVLAERNGI ITKYTLLYRD INIPLLPMEQ LIVPADTTMT LTGLKPDTTY DVKVRAHTSK GPGPYSPSVQ FRTLPVDQVF AKNFHVKAVM KTSVLLSWEI PENYNSAMPF KILYDDGKMV EEVDGRATQK LIVNLKPEKS YSFVLTNRGN SAGGLQHRVT AKTAPDVLRT KPAFIGKTNL DGMITVQLPE VPANENIKGY YIIIVPLKKS RGKFIKPWES PDEMELDELL KEISRKRRSI RYGREVELKP YIAAHFDVLP TEFTLGDDKH YGGFTNKQLQ SGQEYVFFVL AVMEHAESKM YATSPYSDPV VSMDLDPQPI TDEEEGLIWV VGPVLAVVFI ICIVIAILLY KRKRAESDSR KSSIPNNKEI PSHHPTDPVE LRRLNFQTPG MASHPPIPIL ELADHIERLK ANDNLKFSQE YESIDPGQQF TWEHSNLEVN KPKNRYANVI AYDHSRVLLS AIEGIPGSDY VNANYIDGYR KQNAYIATQG SLPETFGDFW RMIWEQRSAT VVMMTKLEER SRVKCDQYWP SRGTETHGLV QVTLLDTVEL ATYCVRTFAL YKNGSSEKRE VRQFQFTAWP DHGVPEHPTP FLAFLRRVKT CNPPDAGPMV VHCSAGVGRT GCFIVIDAML ERIKHEKTVD IYGHVTLMRA QRNYMVQTED QYIFIHDALL EAVTCGNTEV PARNLYAYIQ KLTQIETGEN VTGMELEFKR LASSKAHTSR FISANLPCNK FKNRLVNIMP YESTRVCLQP IRGVEGSDYI NASFIDGYRQ QKAYIATQGP LAETTEDFWR MLWEHNSTIV VMLTKLREMG REKCHQYWPA ERSARYQYFV VDPMAEYNMP QYILREFKVT DARDGQSRTV RQFQFTDWPE QGVPKSGEGF IDFIGQVHKT KEQFGQDGPI SVHCSAGVGR TGVFITLSIV LERMRYEGVV DIFQTVKMLR TQRPAMVQTE DQYQFSYRAA LEYLGSFDHY AT