PTPRA_HUMAN » Receptor-type tyrosine-protein phosphatase alpha

PTPRA_HUMAN » Receptor-type tyrosine-protein phosphatase alpha
Magnify PTPRA_HUMAN » Receptor-type tyrosine-protein phosphatase alphaEnlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PTPRA_HUMAN » Receptor-type tyrosine-protein phosphatase alpha » Protein-tyrosine phosphatase alpha; R-PTP-alpha;
Hydrophobic Thickness 38.0 ± 3.4 Å
Tilt Angle 0 ± 1°
ΔGtransfer -47.4 kcal/mol
ΔGfold -28.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 140-168 (140-174)
Pathways

Developmental Biology (Reactome)

PDB none
OPM none
Complexes none
Interactions

PTPRD, Complex: PTPRD:PTPRA, PubMed

PTPRF, Complex: PTPRA:PTPRF, PubMed

PTPRM, Complex: PTPRM:PTPRA, PubMed

PTPRS, Complex: PTPRS:PTPRA, PubMed

Domains

AA: 265-500, PDBID: 1YFO, Subunit A, Seq Identity:83%, Protein-tyrosine phosphatase

AA: 558-790, PDBID: 1P15, Subunit B, Seq Identity:100%, Protein-tyrosine phosphatase

UniProt annotation for PTPRA_HUMAN » Receptor-type tyrosine-protein phosphatase alpha
CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProt features for PTPRA_HUMAN » Receptor-type tyrosine-protein phosphatase alpha
SIGNAL 1 19 Potential.
CHAIN 20 802 Receptor-type tyrosine-protein phosphatase alpha.
DOMAIN 241 501 Tyrosine-protein phosphatase 1.
DOMAIN 533 791 Tyrosine-protein phosphatase 2.
REGION 442 448 Substrate binding (By similarity).
ACT_SITE 442 442 Phosphocysteine intermediate (By similarity).
ACT_SITE 732 732 Phosphocysteine intermediate (By similarity).
Amino Acid Sequence for PTPRA_HUMAN » Receptor-type tyrosine-protein phosphatase alpha
MDSWFILVLL GSGLICVSAN NATTVAPSVG ITRLINSSTA EPVKEEAKTS NPTSSLTSLS VAPTFSPNIT LGPTYLTTVN SSDSDNGTTR TASTNSIGIT ISPNGTWLPD NQFTDARTEP WEGNSSTAAT TPETFPPSDE TPIIAVMVAL SSLLVIVFII IVLYMLRFKK YKQAGSHSNS KQAGSHSNSF RLSNGRTEDV EPQSVPLLAR SPSTNRKYPP LPVDKLEEEI NRRMADDNKL FREEFNALPA CPIQATCEAA SKEENKEKNR YVNILPYDHS RVHLTPVEGV PDSDYINASF INGYQEKNKF IAAQGPKEET VNDFWRMIWE QNTATIVMVT NLKERKECKC AQYWPDQGCW TYGNIRVSVE DVTVLVDYTV RKFCIQQVGD MTNRKPQRLI TQFHFTSWPD FGVPFTPIGM LKFLKKVKAC NPQYAGAIVV HCSAGVGRTG TFVVIDAMLD MMHTERKVDV YGFVSRIRAQ RCQMVQTDMQ YVFIYQALLE HYLYGDTELE VTSLETHLQK IYNKIPGTSN NGLEEEFKKL TSIKIQNDKM RTGNLPANMK KNRVLQIIPY EFNRVIIPVK RGEENTDYVN ASFIDGYRQK DSYIASQGPL LHTIEDFWRM IWEWKSCSIV MLTELEERGQ EKCAQYWPSD GLVSYGDITV ELKKEEECES YTVRDLLVTN TRENKSRQIR QFHFHGWPEV GIPSDGKGMI SIIAAVQKQQ QQSGNHPITV HCSAGAGRTG TFCALSTVLE RVKAEGILDV FQTVKSLRLQ RPHMVQTLEQ YEFCYKVVQE YIDAFSDYAN FK