PTPR2_HUMAN » Receptor-type tyrosine-protein phosphatase N2

PTPR2_HUMAN » Receptor-type tyrosine-protein phosphatase N2
Magnify PTPR2_HUMAN » Receptor-type tyrosine-protein phosphatase N2Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PTPR2_HUMAN » Receptor-type tyrosine-protein phosphatase N2 » R-PTP-N2; Islet cell autoantigen-related protein;IAR; ICAAR; Phogrin;
Hydrophobic Thickness 34.8 ± 1.2 Å
Tilt Angle 0 ± 0°
ΔGtransfer -44.2 kcal/mol
ΔGfold -18.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 612-639 (610-641)
Pathways

Type I diabetes mellitus (KEGG)

PDB 4hti (502-599), 4htj (502-599), 2qep (715-1010)
OPM none
Complexes none
Interactions none
Domains

AA: 59-142, RESP18 domain

AA: 509-597, PDBID: 4HTI, Subunit A, Seq Identity:100%, Protein-tyrosine phosphatase receptor IA-2

AA: 770-1004, PDBID: 2QEP, Subunit B, Seq Identity:100%, Protein-tyrosine phosphatase

UniProt annotation for PTPR2_HUMAN » Receptor-type tyrosine-protein phosphatase N2
FUNCTION: Implicated in development of nervous system and pancreatic endocrine cells.

CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.

TISSUE SPECIFICITY: Highest levels in brain and pancreas. Lower levels in trachea, prostate, stomach and spinal chord.

DOMAIN: The cytoplasmic domain appears to contain the autoantigenic epitopes.

MISCELLANEOUS: Autoantigen in insulin-dependent diabetes mellitus (IDDM).

UniProt features for PTPR2_HUMAN » Receptor-type tyrosine-protein phosphatase N2
SIGNAL 1 21 Potential.
CHAIN 22 1015 Receptor-type tyrosine-protein phosphatase N2.
DOMAIN 745 1005 Tyrosine-protein phosphatase.
REGION 945 951 Substrate binding (By similarity).
ACT_SITE 945 945 Phosphocysteine intermediate (By similarity).
SITE 427 428 Cleavage (Potential).
Amino Acid Sequence for PTPR2_HUMAN » Receptor-type tyrosine-protein phosphatase N2
MGPPLPLLLL LLLLLPPRVL PAAPSSVPRG RQLPGRLGCL LEEGLCGASE ACVNDGVFGR CQKVPAMDFY RYEVSPVALQ RLRVALQKLS GTGFTWQDDY TQYVMDQELA DLPKTYLRRP EASSPARPSK HSVGSERRYS REGGAALANA LRRHLPFLEA LSQAPASDVL ARTHTAQDRP PAEGDDRFSE SILTYVAHTS ALTYPPGSRT QLREDLLPRT LGQLQPDELS PKVDSGVDRH HLMAALSAYA AQRPPAPPGE GSLEPQYLLR APSRMPRPLL APAAPQKWPS PLGDSEDPSS TGDGARIHTL LKDLQRQPAE VRGLSGLELD GMAELMAGLM QGVDHGVARG SPGRAALGES GEQADGPKAT LRGDSFPDDG VQDDDDRLYQ EVHRLSATLG GLLQDHGSRL LPGALPFARP LDMERKKSEH PESSLSSEEE TAGVENVKSQ TYSKDLLGQQ PHSEPGAAAF GELQNQMPGP SKEEQSLPAG AQEALSDGLQ LEVQPSEEEA RGYIVTDRDP LRPEEGRRLV EDVARLLQVP SSAFADVEVL GPAVTFKVSA NVQNVTTEDV EKATVDNKDK LEETSGLKIL QTGVGSKSKL KFLPPQAEQE DSTKFIALTL VSLACILGVL LASGLIYCLR HSSQHRLKEK LSGLGGDPGA DATAAYQELC RQRMATRPPD RPEGPHTSRI SSVSSQFSDG PIPSPSARSS ASSWSEEPVQ SNMDISTGHM ILSYMEDHLK NKNRLEKEWE ALCAYQAEPN SSFVAQREEN VPKNRSLAVL TYDHSRVLLK AENSHSHSDY INASPIMDHD PRNPAYIATQ GPLPATVADF WQMVWESGCV VIVMLTPLAE NGVRQCYHYW PDEGSNLYHI YEVNLVSEHI WCEDFLVRSF YLKNLQTNET RTVTQFHFLS WYDRGVPSSS RSLLDFRRKV NKCYRGRSCP IIVHCSDGAG RSGTYVLIDM VLNKMAKGAK EIDIAATLEH LRDQRPGMVQ TKEQFEFALT AVAEEVNAIL KALPQ