PTN1_HUMAN » Tyrosine-protein phosphatase non-receptor type 1

PTN1_HUMAN » Tyrosine-protein phosphatase non-receptor type 1
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
PTN1_HUMAN » Tyrosine-protein phosphatase non-receptor type 1 » Protein-tyrosine phosphatase 1B;PTP-1B;
Hydrophobic Thickness 27.8 ± 4.0 Å
Tilt Angle 27 ± 1°
ΔGtransfer -12.9 kcal/mol
ΔGfold -6.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 406-427 (399-427)
Pathways none
PDB 1lqf (A/B/C/D=1-283), 2fjn (A/B=1-298), 2fjm (A/B=1-298), 2cm3 (A/B=1-298), 1q6t (A/B=1-298), 1q6s (A/B=1-298), 1q6p (A/B=1-298), 1q6n (A/B=1-298), 1jf7 (A/B=1-298), 3zmp (A/B=1-321), 4bjo (A/B=2-321), 2b4s (A/C=1-298), 3eu0 (A=1-282), 3cwe (A=1-283), 4qbe (A=1-298), 3sme (A=1-298), 2f71 (A=1-298), 2f70 (A=1-298), 2f6z (A=1-298), 2f6y (A=1-298), 2f6w (A=1-298), 2f6v (A=1-298), 2f6t (A=1-298), 2f6f (A=1-298), 2cne (A=1-298), 2cmc (A=1-298), 2cmb (A=1-298), 1t4j (A=1-298), 1t49 (A=1-298), 1t48 (A=1-298), 1q6m (A=1-298), 1q6j (A=1-298), 1pa1 (A=1-298), 1nwl (A=1-298), 1nwe (A=1-298), 1kav (A=1-298), 1kak (A=1-298), 1i57 (A=1-298), 1gfy (A=1-298), 1g7g (A=1-298), 1g7f (A=1-298), 1g1h (A=1-298), 1g1g (A=1-298), 1g1f (A=1-298), 1ecv (A=1-298), 1c88 (A=1-298), 1c87 (A=1-298), 1c86 (A=1-298), 1c85 (A=1-298), 1c84 (A=1-298), 1c83 (A=1-298), 1bzh (A=1-298), 4qbw (A=1-299), 4qap (A=1-299), 4qah (A=1-299), 2zn7 (A=1-299), 2zmm (A=1-299), 2qbs (A=1-299), 2qbr (A=1-299), 2qbq (A=1-299), 2qbp (A=1-299), 2nta (A=1-299), 2nt7 (A=1-299), 2hb1 (A=1-299), 2h4k (A=1-299), 2h4g (A=1-299), 2b07 (A=1-299), 2azr (A=1-299), 4i8n (A=1-320), 3zv2 (A=1-320), 3zmq (A=1-321), 3qkq (A=1-321), 3qkp (A=1-321), 3i80 (A=1-321), 3i7z (A=1-321), 3eb1 (A=1-321), 3eax (A=1-321), 3d9c (A=1-321), 2vey (A=1-321), 2vex (A=1-321), 2vew (A=1-321), 2vev (A=1-321), 2veu (A=1-321), 2hnq (A=1-321), 2hnp (A=1-321), 2cni (A=1-321), 2cnh (A=1-321), 2cng (A=1-321), 2cnf (A=1-321), 2cma (A=1-321), 2cm8 (A=1-321), 2cm7 (A=1-321), 2bge (A=1-321), 2bgd (A=1-321), 1xbo (A=1-321), 1wax (A=1-321), 1sug (A=1-321), 1qxk (A=1-321), 1q1m (A=1-321), 1pyn (A=1-321), 1pxh (A=1-321), 1pty (A=1-321), 1ptv (A=1-321), 1ptu (A=1-321), 1ptt (A=1-321), 1ph0 (A=1-321), 1onz (A=1-321), 1ony (A=1-321), 1oev (A=1-321), 1oeu (A=1-321), 1oet (A=1-321), 1oes (A=1-321), 1nz7 (A=1-321), 1no6 (A=1-321), 1nny (A=1-321), 1nl9 (A=1-321), 1l8g (A=1-321), 1eeo (A=1-321), 1een (A=1-321), 1bzc (A=1-321), 1aax (A=1-321), 1a5y (A=1-330), 3a5k (A=2-298), 2cm2 (A=2-298), 1bzj (A=2-298), 3a5j (A=2-321), 1oeo (X=1-321), 1oem (X=1-321)
OPM none
Complexes none
Interactions none
Domains

AA: 40-276, PDBID: 1A5Y, Subunit A, Seq Identity:100%, Protein-tyrosine phosphatase

UniProt annotation for PTN1_HUMAN » Tyrosine-protein phosphatase non-receptor type 1
FUNCTION: Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET.
UniProt features for PTN1_HUMAN » Tyrosine-protein phosphatase non-receptor type 1
CHAIN 1 435 Tyrosine-protein phosphatase non-receptor type 1.

DOMAIN 3 277 Tyrosine-protein phosphatase.

REGION 215 221 Substrate binding.

ACT_SITE 215 215 Phosphocysteine intermediate.

CROSSLNK 215 216 N,N-(cysteine-1,S-diyl)serine (Cys-Ser); in inhibited form.

Amino Acid Sequence for PTN1_HUMAN » Tyrosine-protein phosphatase non-receptor type 1
MEMEKEFEQI DKSGSWAAIY QDIRHEASDF PCRVAKLPKN KNRNRYRDVS PFDHSRIKLH QEDNDYINAS LIKMEEAQRS YILTQGPLPN TCGHFWEMVW EQKSRGVVML NRVMEKGSLK CAQYWPQKEE KEMIFEDTNL KLTLISEDIK SYYTVRQLEL ENLTTQETRE ILHFHYTTWP DFGVPESPAS FLNFLFKVRE SGSLSPEHGP VVVHCSAGIG RSGTFCLADT CLLLMDKRKD PSSVDIKKVL LEMRKFRMGL IQTADQLRFS YLAVIEGAKF IMGDSSVQDQ WKELSHEDLE PPPEHIPPPP RPPKRILEPH NGKCREFFPN HQWVKEETQE DKDCPIKEEK GSPLNAAPYG IESMSQDTEV RSRVVGGSLR GAQAASPAKG EPSLPEKDED HALSYWKPFL VNMCVATVLT AGAYLCYRFL FNSNT