PTK7_HUMAN » Inactive tyrosine-protein kinase 7

PTK7_HUMAN » Inactive tyrosine-protein kinase 7
Magnify PTK7_HUMAN » Inactive tyrosine-protein kinase 7Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PTK7_HUMAN » Inactive tyrosine-protein kinase 7 » Colon carcinoma kinase 4;CCK-4; Protein-tyrosine kinase 7;Pseudo tyrosine kinase receptor 7;Tyrosine-protein kinase-like 7;
Hydrophobic Thickness 34.8 ± 2.2 Å
Tilt Angle 9 ± 8°
ΔGtransfer -38.8 kcal/mol
ΔGfold -19.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 703-726 (698-733)
Pathways none
PDB none
OPM none
Complexes none
Interactions

RYK, Complex: RYK:PTK7, PubMed

Domains

AA: 32-105, PDBID: 2LVC, Subunit A, Seq Identity:28%, Immunoglobulin domain

AA: 128-204, PDBID: 2EO9, Subunit A, Seq Identity:30%, Immunoglobulin domain

AA: 226-304, PDBID: 4W4O, Subunit C, Seq Identity:27%, Immunoglobulin domain

AA: 328-408, PDBID: 1HCF, Subunit Y, Seq Identity:33%, Immunoglobulin I-set domain

AA: 412-498, PDBID: 2OM5, Subunit A, Seq Identity:36%, Immunoglobulin I-set domain

AA: 503-574, PDBID: 1GL4, Subunit B, Seq Identity:34%, Immunoglobulin domain

AA: 592-681, PDBID: 2EDJ, Subunit A, Seq Identity:36%, Immunoglobulin I-set domain

AA: 796-1061, PDBID: 1YVJ, Subunit A, Seq Identity:37%, Protein tyrosine kinase

UniProt annotation for PTK7_HUMAN » Inactive tyrosine-protein kinase 7
FUNCTION: Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.

SUBUNIT: Interacts with CTNNB1.

TISSUE SPECIFICITY: Highly expressed in lung, liver, pancreas, kidney, placenta and melanocytes. Weakly expressed in thyroid gland, ovary, brain, heart and skeletal muscle. Also expressed in erythroleukemia cells. But not expressed in colon.

INDUCTION: Higher expression in cell lines established from normal non-tumorigenic tissues compared to cell lines established from highly metastatic invasive carcinomas (at protein level).

DOMAIN: The protein kinase domain is predicted to be catalytically inactive.

UniProt features for PTK7_HUMAN » Inactive tyrosine-protein kinase 7
SIGNAL 1 30 Potential.
CHAIN 31 1070 Inactive tyrosine-protein kinase 7.
DOMAIN 31 120 Ig-like C2-type 1.
DOMAIN 128 218 Ig-like C2-type 2.
DOMAIN 225 317 Ig-like C2-type 3.
DOMAIN 309 407 Ig-like C2-type 4.
DOMAIN 412 497 Ig-like C2-type 5.
DOMAIN 503 586 Ig-like C2-type 6.
DOMAIN 578 680 Ig-like C2-type 7.
DOMAIN 796 1066 Protein kinase; inactive.
REGION 794 1070 Interaction with CTNNB1.
SITE 621 622 Cleavage; by MMP14.
DISULFID 53 101 By similarity.
DISULFID 150 200 By similarity.
DISULFID 246 301 By similarity.
DISULFID 343 391 By similarity.
DISULFID 433 481 By similarity.
DISULFID 524 570 By similarity.
DISULFID 613 664 By similarity.
Amino Acid Sequence for PTK7_HUMAN » Inactive tyrosine-protein kinase 7
MGAARGSPAR PRRLPLLSVL LLPLLGGTQT AIVFIKQPSS QDALQGRRAL LRCEVEAPGP VHVYWLLDGA PVQDTERRFA QGSSLSFAAV DRLQDSGTFQ CVARDDVTGE EARSANASFN IKWIEAGPVV LKHPASEAEI QPQTQVTLRC HIDGHPRPTY QWFRDGTPLS DGQSNHTVSS KERNLTLRPA GPEHSGLYSC CAHSAFGQAC SSQNFTLSIA DESFARVVLA PQDVVVARYE EAMFHCQFSA QPPPSLQWLF EDETPITNRS RPPHLRRATV FANGSLLLTQ VRPRNAGIYR CIGQGQRGPP IILEATLHLA EIEDMPLFEP RVFTAGSEER VTCLPPKGLP EPSVWWEHAG VRLPTHGRVY QKGHELVLAN IAESDAGVYT CHAANLAGQR RQDVNITVAT VPSWLKKPQD SQLEEGKPGY LDCLTQATPK PTVVWYRNQM LISEDSRFEV FKNGTLRINS VEVYDGTWYR CMSSTPAGSI EAQARVQVLE KLKFTPPPQP QQCMEFDKEA TVPCSATGRE KPTIKWERAD GSSLPEWVTD NAGTLHFARV TRDDAGNYTC IASNGPQGQI RAHVQLTVAV FITFKVEPER TTVYQGHTAL LQCEAQGDPK PLIQWKGKDR ILDPTKLGPR MHIFQNGSLV IHDVAPEDSG RYTCIAGNSC NIKHTEAPLY VVDKPVPEES EGPGSPPPYK MIQTIGLSVG AAVAYIIAVL GLMFYCKKRC KAKRLQKQPE GEEPEMECLN GGPLQNGQPS AEIQEEVALT SLGSGPAATN KRHSTSDKMH FPRSSLQPIT TLGKSEFGEV FLAKAQGLEE GVAETLVLVK SLQSKDEQQQ LDFRRELEMF GKLNHANVVR LLGLCREAEP HYMVLEYVDL GDLKQFLRIS KSKDEKLKSQ PLSTKQKVAL CTQVALGMEH LSNNRFVHKD LAARNCLVSA QRQVKVSALG LSKDVYNSEY YHFRQAWVPL RWMSPEAILE GDFSTKSDVW AFGVLMWEVF THGEMPHGGQ ADDEVLADLQ AGKARLPQPE GCPSKLYRLM QRCWALSPKD RPSFSEIASA LGDSTVDSKP