PTCRA_HUMAN » Pre T-cell antigen receptor alpha

PTCRA_HUMAN » Pre T-cell antigen receptor alpha
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PTCRA_HUMAN » Pre T-cell antigen receptor alpha » pT-alpha; pTa; pT-alpha-TCR;
Hydrophobic Thickness 29.8 ± 4.0 Å
Tilt Angle 30 ± 3°
ΔGtransfer -20.7 kcal/mol
ΔGfold -6.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 148-170 (147-172)
Pathways

Notch signaling pathway (KEGG)

Transcriptional misregulation in cancer (KEGG)

PDB 3of6 (D/E/F=17-135)
OPM none
Complexes

PTCRA:PTCRA_HUMAN

Interactions

NOTC3, Complex: PTCRA:NOTC3, PubMed

PTCRA, Complex: Homodimer of pre T-cell antigen receptor alpha, PDBID: 3OF6

UBP19, Complex: UBP19:PTCRA

Domains

AA: 20-146, PDBID: 3OF6, Subunit E, Seq Identity:100%, Pre-T-cell antigen receptor

UniProt annotation for PTCRA_HUMAN » Pre T-cell antigen receptor alpha
FUNCTION: The pre-T-cell receptor complex (composed of PTCRA, TCRB and the CD3 complex) regulates early T-cell development.

SUBUNIT: Heterodimer with TCRB; disulfide linked. This heterodimer assembles with CD3 proteins into a signaling-competent pre-T-cell receptor complex. Interacts with RHBDD1.

TISSUE SPECIFICITY: Expressed in immature but not mature T-cells. Also found in CD34+ cells from peripheral blood, CD34+ precursors from umbilical cord blood and adult bone marrow.

DEVELOPMENTAL STAGE: Expressed in fetal life in CD34+ progenitors present in the liver at 18 weeks of gestation but is absent in CD34+ precursors from fetal bone marrow at any developmental stage up to 22 weeks.

UniProt features for PTCRA_HUMAN » Pre T-cell antigen receptor alpha
SIGNAL 1 23 Potential.
CHAIN 24 281 Pre T-cell antigen receptor alpha.
DISULFID 47 107
DISULFID 135 135 Interchain (with TCRB) (Probable).
Amino Acid Sequence for PTCRA_HUMAN » Pre T-cell antigen receptor alpha
MAGTWLLLLL ALGCPALPTG VGGTPFPSLA PPIMLLVDGK QQMVVVCLVL DVAPPGLDSP IWFSAGNGSA LDAFTYGPSP ATDGTWTNLA HLSLPSEELA SWEPLVCHTG PGAEGHSRST QPMHLSGEAS TARTCPQEPL RGTPGGALWL GVLRLLLFKL LLFDLLLTCS CLCDPAGPLP SPATTTRLRA LGSHRLHPAT ETGGREATSS PRPQPRDRRW GDTPPGRKPG SPVWGEGSYL SSYPTCPAQA WCSRSALRAP SSSLGAFFAG DLPPPLQAGA A