PSD2_HUMAN » PH and SEC7 domain-containing protein 2

PSD2_HUMAN » PH and SEC7 domain-containing protein 2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PSD2_HUMAN » PH and SEC7 domain-containing protein 2 » Pleckstrin homology and SEC7 domain-containing protein 2;
Hydrophobic Thickness 34.4 ± 2.0 Å
Tilt Angle 10 ± 7°
ΔGtransfer -18.8 kcal/mol
ΔGfold -8.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 613-637 (610-640)
Pathways

Endocytosis (KEGG)

Glycerophospholipid metabolism (KEGG)

PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 295-464, PDBID: 1BC9, Subunit A, Seq Identity:22%, Sec7 domain

AA: 514-625, PDBID: 2DHJ, Subunit A, Seq Identity:35%, Pleckstrin homology domain

UniProt features for PSD2_HUMAN » PH and SEC7 domain-containing protein 2
CHAIN 1 771 PH and SEC7 domain-containing protein 2.
DOMAIN 260 462 SEC7.
DOMAIN 512 625 PH.
COILED 651 680 Potential.
Amino Acid Sequence for PSD2_HUMAN » PH and SEC7 domain-containing protein 2
MEEDKLLSAV PEEGDATRDP GPEPEEEPGV RNGMASEGLN SSLCSPGHER RGTPADTEEP TKDPDVAFHG LSLGLSLTNG LALGPDLNIL EDSAESRPWR AGVLAEGDNA SRSLYPDAED PQLGLDGPGE PDVRDGFSAT FEKILESELL RGTQYSSLDS LDGLSLTDES DSCVSFEAPL TPLIQQRARD SPEPGAGLGI GDMAFEGDMG AAGGDGELGS PLRRSISSSR SENVLSRLSL MAMPNGFHED GPQGPGGDED DDEEDTDKLL NSASDPSLKD GLSDSDSELS SSEGLEPGSA DPLANGCQGV SEAAHRLARR LYHLEGFQRC DVARQLGKNN EFSRLVAGEY LSFFDFSGLT LDRALRTFLK AFPLMGETQE RERVLTHFSR RYCQCNPDDS TSEDGIHTLT CALMLLNTDL HGHNIGKKMS CQQFIANLDQ LNDGQDFAKD LLKTLYNSIK NEKLEWAIDE DELRKSLSEL VDDKFGTGTK KVTRILDGGN PFLDVPQALS ATTYKHGVLT RKTHADMDGK RTPRGRRGWK KFYAVLKGTI LYLQKDEYRP DKALSEGDLK NAIRVHHALA TRASDYSKKS NVLKLKTADW RVFLFQAPSK EEMLSWILRI NLVAAIFSAP AFPAAVSSMK KFCRPLLPSC TTRLCQEEQL RSHENKLRQL TAELAEHRCH PVERGIKSKE AEEYRLKEHY LTFEKSRYET YIHLLAMKIK VGSDDLERIE ARLATLEGDD PSLRKTHSSP ALSQGHVTGS KTTKDATGPD T