PRTG_HUMAN » Protogenin

PRTG_HUMAN » Protogenin
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PRTG_HUMAN » Protogenin » Protein Shen-Dan;
Hydrophobic Thickness 32.0 ± 3.6 Å
Tilt Angle 7 ± 4°
ΔGtransfer -41.2 kcal/mol
ΔGfold -21.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 949-971 (945-976)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 39-131, PDBID: 2YD5, Subunit A, Seq Identity:33%, Immunoglobulin I-set domain

AA: 134-208, PDBID: 4HWU, Subunit A, Seq Identity:34%, Immunoglobulin domain

AA: 234-308, PDBID: 2EO9, Subunit A, Seq Identity:38%, Immunoglobulin domain

AA: 327-412, PDBID: 3PXH, Subunit A, Seq Identity:39%, Immunoglobulin I-set domain

AA: 420-505, PDBID: 1X5Z, Subunit A, Seq Identity:32%, Fibronectin type III domain

AA: 518-603, PDBID: 2ED8, Subunit A, Seq Identity:35%, Fibronectin type III domain

AA: 619-700, PDBID: 1X5G, Subunit A, Seq Identity:32%, Fibronectin type III domain

AA: 723-807, PDBID: 1X5J, Subunit A, Seq Identity:28%, Fibronectin type III domain

AA: 821-907, PDBID: 1X5K, Subunit A, Seq Identity:29%, Fibronectin type III domain

UniProt annotation for PRTG_HUMAN » Protogenin
FUNCTION: May play a role in anteroposterior axis elongation.
UniProt features for PRTG_HUMAN » Protogenin
SIGNAL 1 35 Potential.
CHAIN 36 1150 Protogenin.
DOMAIN 36 130 Ig-like 1.
DOMAIN 135 222 Ig-like 2.
DOMAIN 235 322 Ig-like 3.
DOMAIN 327 411 Ig-like 4.
DOMAIN 419 512 Fibronectin type-III 1.
DOMAIN 517 609 Fibronectin type-III 2.
DOMAIN 615 708 Fibronectin type-III 3.
DOMAIN 721 815 Fibronectin type-III 4.
DOMAIN 819 914 Fibronectin type-III 5.
DISULFID 60 113 By similarity.
DISULFID 156 205 By similarity.
DISULFID 256 304 By similarity.
DISULFID 348 395 By similarity.
Amino Acid Sequence for PRTG_HUMAN » Protogenin
MAPPLRPLAR LRPPGMLLRA LLLLLLLSPL PGVWCFSELS FVKEPQDVTV TRKDPVVLDC QAHGEVPIKV TWLKNGAKMS ENKRIEVLSN GSLYISEVEG RRGEQSDEGF YQCLAMNKYG AILSQKAHLA LSTISAFEVQ PISTEVHEGG VARFACKISS HPPAVITWEF NRTTLPMTMD RITALPTGVL QIYDVSQRDS GNYRCIAATV AHRRKSMEAS LTVIPAKESK SFHTPTIIAG PQNITTSLHQ TVVLECMATG NPKPIISWSR LDHKSIDVFN TRVLGNGNLM ISDVRLQHAG VYVCRATTPG TRNFTVAMAT LTVLAPPSFV EWPESLTRPR AGTARFVCQA EGIPSPKMSW LKNGRKIHSN GRIKMYNSKL VINQIIPEDD AIYQCMAENS QGSILSRARL TVVMSEDRPS APYNVHAETM SSSAILLAWE RPLYNSDKVI AYSVHYMKAE GLNNEEYQVV IGNDTTHYII DDLEPASNYT FYIVAYMPMG ASQMSDHVTQ NTLEDVPLRP PEISLTSRSP TDILISWLPI PAKYRRGQVV LYRLSFRLST ENSIQVLELP GTTHEYLLEG LKPDSVYLVR ITAATRVGLG ESSVWTSHRT PKATSVKAPK SPELHLEPLN CTTISVRWQQ DVEDTAAIQG YKLYYKEEGQ QENGPIFLDT KDLLYTLSGL DPRRKYHVRL LAYNNIDDGY QADQTVSTPG CVSVRDRMVP PPPPPHHLYA KANTSSSIFL HWRRPAFTAA QIINYTIRCN PVGLQNASLV LYLQTSETHM LVQGLEPNTK YEFAVRLHVD QLSSPWSPVV YHSTLPEAPA GPPVGVKVTL IEDDTALVSW KPPDGPETVV TRYTILYASR KAWIAGEWQV LHREGAITMA LLENLVAGNV YIVKISASNE VGEGPFSNSV ELAVLPKETS ESNQRPKRLD SADAKVYSGY YHLDQKSMTG IAVGVGIALT CILICVLILI YRSKARKSSA SKTAQNGTQQ LPRTSASLAS GNEVGKNLEG AVGNEESLMP MIMPNSFIDA KGGTDLIINS YGPIIKNNSK KKWFFFQDSK KIQVEQPQRR FTPAVCFYQP GTTVLISDED SPSSPGQTTS FSRPFGVAAD TEHSANSEGS HETGDSGRFS HESNDEIHLS SVISTTPPNL