PRLR_HUMAN » Prolactin receptor

PRLR_HUMAN » Prolactin receptor
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PRLR_HUMAN » Prolactin receptor » PRL-R;
Hydrophobic Thickness 32.0 ± 1.2 Å
Tilt Angle 0 ± 1°
ΔGtransfer -42.8 kcal/mol
ΔGfold -21.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 235-259 (234-263)
Pathways

Cytokine-cytokine receptor interaction (KEGG)

Immune System (Reactome)

Jak-STAT signaling pathway (KEGG)

Neuroactive ligand-receptor interaction (KEGG)

PI3K-Akt signaling pathway (KEGG)

Signal Transduction (Reactome)

PDB 2lfg (123-234), 1bp3 (B=25-235), 3ncf (B=26-234), 3nce (B=26-234), 3ncc (B=26-234), 3ncb (B=26-234), 3n0p (B=26-234), 3n06 (B=26-234), 3mzg (B=26-234), 4i18 (C/R=25-235), 3d48 (R=25-234)
OPM 3nce
Complexes none
Interactions

GHR, Complex: GHR:PRLR, PubMed

ITB1, Complex: ITB1:PRLR, PubMed

PRLR, Complex: Homodimer of prolactin receptor, PDBID: 4I18

SHPS1, Complex: PRLR:SHPS1, PubMed

Domains

AA: 22-120, PDBID: 1BP3, Subunit B, Seq Identity:100%, Erythropoietin receptor, ligand binding

UniProt annotation for PRLR_HUMAN » Prolactin receptor
FUNCTION: This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.

SUBUNIT: Homodimer upon hormone binding. Interacts with SMARCA1. Interacts with GH1. Interacts with CSH. Interacts with NEK3 and VAV2 and this interaction is prolactin-dependent.

TISSUE SPECIFICITY: Expressed in breast, placenta, kidney, liver and pancreas.

DOMAIN: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell- surface receptor binding.

DOMAIN: The box 1 motif is required for JAK interaction and/or activation.

DISEASE: Multiple fibroadenomas of the breast (MFAB) OMIM: A benign breast disease marked by lobuloalveolar growth with abnormally high proliferation of the epithelium, and characterized by the presence of more than 3 fibroadenomas in one breast. Fibroadenomas are adenomas containing fibrous tissue. mutations affecting the gene represented in this entry.

DISEASE: Hyperprolactinemia (HPRL) OMIM: A disorder characterized by increased levels of prolactin in the blood not associated with gestation or the puerperium. HPRL may result in infertility, hypogonadism, and galactorrhea. mutations affecting the gene represented in this entry.

UniProt features for PRLR_HUMAN » Prolactin receptor
SIGNAL 1 24
CHAIN 25 622 Prolactin receptor.
DOMAIN 27 121 Fibronectin type-III 1.
DOMAIN 127 227 Fibronectin type-III 2.
MOTIF 215 219 WSXWS motif.
MOTIF 267 275 Box 1 motif.
DISULFID 36 46
DISULFID 75 86
Amino Acid Sequence for PRLR_HUMAN » Prolactin receptor
MKENVASATV FTLLLFLNTC LLNGQLPPGK PEIFKCRSPN KETFTCWWRP GTDGGLPTNY SLTYHREGET LMHECPDYIT GGPNSCHFGK QYTSMWRTYI MMVNATNQMG SSFSDELYVD VTYIVQPDPP LELAVEVKQP EDRKPYLWIK WSPPTLIDLK TGWFTLLYEI RLKPEKAAEW EIHFAGQQTE FKILSLHPGQ KYLVQVRCKP DHGYWSAWSP ATFIQIPSDF TMNDTTVWIS VAVLSAVICL IIVWAVALKG YSMVTCIFPP VPGPKIKGFD AHLLEKGKSE ELLSALGCQD FPPTSDYEDL LVEYLEVDDS EDQHLMSVHS KEHPSQGMKP TYLDPDTDSG RGSCDSPSLL SEKCEEPQAN PSTFYDPEVI EKPENPETTH TWDPQCISME GKIPYFHAGG SKCSTWPLPQ PSQHNPRSSY HNITDVCELA VGPAGAPATL LNEAGKDALK SSQTIKSREE GKATQQREVE SFHSETDQDT PWLLPQEKTP FGSAKPLDYV EIHKVNKDGA LSLLPKQREN SGKPKKPGTP ENNKEYAKVS GVMDNNILVL VPDPHAKNVA CFEESAKEAP PSLEQNQAEK ALANFTATSS KCRLQLGGLD YLDPACFTHS FH