PREB_HUMAN » Prolactin regulatory element-binding protein

PREB_HUMAN » Prolactin regulatory element-binding protein
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
PREB_HUMAN » Prolactin regulatory element-binding protein » Mammalian guanine nucleotide exchange factor mSec12;
Hydrophobic Thickness 37.6 ± 2.4 Å
Tilt Angle 0 ± 0°
ΔGtransfer -40.9 kcal/mol
ΔGfold -20.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome, HMDB
Topology In
TM Segments 389-413 (388-413)
Pathways

Membrane Trafficking (Reactome)

Protein processing in endoplasmic reticulum (KEGG)

PDB none
OPM none
Complexes none
Interactions

TGFR1, Complex: TGFR1:PREB, PubMed

Domains

AA: 144-182, PDBID: 4JSN, Subunit C, Seq Identity:44%, WD domain, G-beta repeat

UniProt annotation for PREB_HUMAN » Prolactin regulatory element-binding protein
FUNCTION: Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription (By similarity). Guanine nucleotide exchange factor that activates SARA2. Required for the formation of COPII transport vesicles from the ER.

SUBUNIT: Binds SARA2.

TISSUE SPECIFICITY: Ubiquitous.

UniProt features for PREB_HUMAN » Prolactin regulatory element-binding protein
CHAIN 1 417 Prolactin regulatory element-binding protein.
REPEAT 152 191 WD 1.
REPEAT 194 232 WD 2.
REPEAT 298 337 WD 3.
Amino Acid Sequence for PREB_HUMAN » Prolactin regulatory element-binding protein
MGRRRAPELY RAPFPLYALQ VDPSTGLLIA AGGGGAAKTG IKNGVHFLQL ELINGRLSAS LLHSHDTETR ATMNLALAGD ILAAGQDAHC QLLRFQAHQQ QGNKAEKAGS KEQGPRQRKG AAPAEKKCGA ETQHEGLELR VENLQAVQTD FSSDPLQKVV CFNHDNTLLA TGGTDGYVRV WKVPSLEKVL EFKAHEGEIE DLALGPDGKL VTVGRDLKAS VWQKDQLVTQ LHWQENGPTF SSTPYRYQAC RFGQVPDQPA GLRLFTVQIP HKRLRQPPPC YLTAWDGSNF LPLRTKSCGH EVVSCLDVSE SGTFLGLGTV TGSVAIYIAF SLQCLYYVRE AHGIVVTDVA FLPEKGRGPE LLGSHETALF SVAVDSRCQL HLLPSRRSVP VWLLLLLCVG LIIVTILLLQ SAFPGFL