PPR29_HUMAN » Protein phosphatase 1 regulatory subunit 29

PPR29_HUMAN » Protein phosphatase 1 regulatory subunit 29
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PPR29_HUMAN » Protein phosphatase 1 regulatory subunit 29 » Extracellular leucine-rich repeat and fibronectin type III domain-containing protein 2;Leucine-rich repeat and fibronectin type-III domain-containing protein 6;Leucine-rich repeat-containing protein 62;
Hydrophobic Thickness 34.4 ± 3.0 Å
Tilt Angle 19 ± 8°
ΔGtransfer -24.0 kcal/mol
ΔGfold -17.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 394-419 (393-430)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 79-139, PDBID: 2Z7X, Subunit A, Seq Identity:42%, Leucine rich repeat

AA: 132-187, PDBID: 4BSR, Subunit B, Seq Identity:41%, Leucine rich repeat

UniProt annotation for PPR29_HUMAN » Protein phosphatase 1 regulatory subunit 29
FUNCTION: Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes.

SUBUNIT: Interacts with PPP1CA.

UniProt features for PPR29_HUMAN » Protein phosphatase 1 regulatory subunit 29
SIGNAL 1 22 Potential.
CHAIN 23 820 Protein phosphatase 1 regulatory subunit 29.
REPEAT 56 77 LRR 1.
REPEAT 80 101 LRR 2.
REPEAT 104 125 LRR 3.
REPEAT 128 149 LRR 4.
REPEAT 152 173 LRR 5.
DOMAIN 185 247 LRRCT.
DOMAIN 292 379 Fibronectin type-III.
Amino Acid Sequence for PPR29_HUMAN » Protein phosphatase 1 regulatory subunit 29
MLRLGLCAAA LLCVCRPGAV RADCWLIEGD KGYVWLAICS QNQPPYETIP QHINSTVHDL RLNENKLKAV LYSSLNRFGN LTDLNLTKNE ISYIEDGAFL GQSSLQVLQL GYNKLSNLTE GMLRGMSRLQ FLFVQHNLIE VVTPTAFSEC PSLISIDLSS NRLSRLDGAT FASLASLMVC ELAGNPFNCE CDLFGFLAWL VVFNNVTKNY DRLQCESPRE FAGYPLLVPR PYHSLNAITV LQAKCRNGSL PARPVSHPTP YSTDAQREPD ENSGFNPDEI LSVEPPASST TDASAGPAIK LHHVTFTSAT LVVIIPHPYS KMYILVQYNN SYFSDVMTLK NKKEIVTLDK LRAHTEYTFC VTSLRNSRRF NHTCLTFTTR DPVPGDLAPS TSTTTHYIMT ILGCLFGMVI VLGAVYYCLR KRRMQEEKQK SVNVKKTILE MRYGADVDAG SIVHAAQKLG EPPVLPVSRM ASIPSMIGEK LPTAKGLEAG LDTPKVATKG NYIEVRTGAG GDGLARPEDD LPDLENGQGS AAEISTIAKE VDKVNQIINN CIDALKLDSA SFLGGGSSSG DPELAFECQS LPAAAAASSA TGPGALERPS FLSPPYKESS HHPLQRQLSA DAAVTRKTCS VSSSGSIKSA KVFSLDVPDH PAATGLAKGD SKYIEKGSPL NSPLDRLPLV PAGSGGGSGG GGGIHHLEVK PAYHCSEHRH SFPALYYEEG ADSLSQRVSF LKPLTRSKRD STYSQLSPRH YYSGYSSSPE YSSESTHKIW ERFRPYKKHH REEVYMAAGH ALRKKVQFAK DEDLHDILDY WKGVSAQQKL