PORIM_HUMAN » Porimin

PORIM_HUMAN » Porimin
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PORIM_HUMAN » Porimin » Keratinocytes-associated transmembrane protein 3;KCT-3; Pro-oncosis receptor inducing membrane injury;Transmembrane protein 123;
Hydrophobic Thickness 29.2 ± 2.6 Å
Tilt Angle 2 ± 1°
ΔGtransfer -37.7 kcal/mol
ΔGfold -12.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 169-190 (168-194)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 96-201, Multi-glycosylated core protein 24 (MGC-24), sialomucin

UniProt annotation for PORIM_HUMAN » Porimin
FUNCTION: Implicated in oncotic cell death, characterized by cell swelling, organelle swelling, vacuolization and increased membrane permeability.

TISSUE SPECIFICITY: Ubiquitous. Not expressed in ovary. Expressed in keratinocytes.

UniProt features for PORIM_HUMAN » Porimin
SIGNAL 1 26
CHAIN 27 208 Porimin.
Amino Acid Sequence for PORIM_HUMAN » Porimin
MGLGARGAWA ALLLGTLQVL ALLGAAHESA AMAASANIEN SGLPHNSSAN STETLQHVPS DHTNETSNST VKPPTSVASD SSNTTVTTMK PTAASNTTTP GMVSTNMTST TLKSTPKTTS VSQNTSQIST STMTVTHNSS VTSAASSVTI TTTMHSEAKK GSKFDTGSFV GGIVLTLGVL SILYIGCKMY YSRRGIRYRT IDEHDAII