PODO_HUMAN » Podocin

PODO_HUMAN » Podocin
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PODO_HUMAN » Podocin »
Hydrophobic Thickness 34.8 ± 4.8 Å
Tilt Angle 43 ± 10°
ΔGtransfer -32.0 kcal/mol
ΔGfold -21.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 100-129 (100-133)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 126-299, PDBID: 4FVF, Subunit A, Seq Identity:52%, SPFH domain / Band 7 family

UniProt annotation for PODO_HUMAN » Podocin
FUNCTION: Plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton.
UniProt features for PODO_HUMAN » Podocin
CHAIN 1 383 Podocin.
Amino Acid Sequence for PODO_HUMAN » Podocin
MERRARSSSR ESRGRGGRTP HKENKRAKAE RSGGGRGRQE AGPEPSGSGR AGTPGEPRAP AATVVDVDEV RGSGEEGTEV VALLESERPE EGTKSSGLGA CEWLLVLISL LFIIMTFPFS IWFCVKVVQE YERVIIFRLG HLLPGRAKGP GLFFFLPCLD TYHKVDLRLQ TLEIPFHEIV TKDMFIMEID AICYYRMENA SLLLSSLAHV SKAVQFLVQT TMKRLLAHRS LTEILLERKS IAQDAKVALD SVTCIWGIKV ERIEIKDVRL PAGLQHSLAV EAEAQRQAKV RMIAAEAEKA ASESLRMAAE ILSGTPAAVQ LRYLHTLQSL STEKPSTVVL PLPFDLLNCL SSPSNRTQGS LPFPSPSKPV EPLNPKKKDS PML