PLXC1_HUMAN » Plexin-C1

PLXC1_HUMAN » Plexin-C1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PLXC1_HUMAN » Plexin-C1 » Virus-encoded semaphorin protein receptor;
Hydrophobic Thickness 34.8 ± 2.0 Å
Tilt Angle 0 ± 0°
ΔGtransfer -47.0 kcal/mol
ΔGfold -22.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 945-967 (942-976)
Pathways

Axon guidance (KEGG)

Developmental Biology (Reactome)

PDB 3kuz (A/B=1198-1305), 3nvq (B/F=35-507), 3nvn (B=35-507)
OPM none
Complexes

PLXC1:SEM7A_HUMAN

PLXC1:PLXC1_HUMAN

Interactions

PLXC1, Complex: Homodimer of plexin-C1, PDBID: 3KUZ

SEM7A, Complex: PLXC1:SEM7A, PDBID: 3NVQ

Domains

AA: 82-439, PDBID: 3NVN, Subunit B, Seq Identity:100%, Sema domain

AA: 454-507, PDBID: 3NVN, Subunit B, Seq Identity:100%, Plexin repeat

AA: 663-750, PDBID: 2UZY, Subunit B, Seq Identity:19%, IPT/TIG domain

AA: 754-840, PDBID: 3MLP, Subunit E, Seq Identity:23%, IPT/TIG domain

AA: 1012-1535, PDBID: 3KUZ, Subunit B, Seq Identity:100%, Plexin cytoplasmic RasGAP domain

UniProt annotation for PLXC1_HUMAN » Plexin-C1
FUNCTION: Receptor for SEMA7A, for smallpox semaphorin A39R, vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and IL8 (By similarity).

SUBUNIT: Monomer. Homodimer. Interacts with SEMA7A.

TISSUE SPECIFICITY: Detected in heart, brain, lung, spleen and placenta.

UniProt features for PLXC1_HUMAN » Plexin-C1
SIGNAL 1 34 Potential.
CHAIN 35 1568 Plexin-C1.
DOMAIN 35 452 Sema.
DISULFID 64 87
DISULFID 156 194
DISULFID 226 354
DISULFID 283 329
DISULFID 455 472
DISULFID 461 506
DISULFID 464 481
DISULFID 475 487
Amino Acid Sequence for PLXC1_HUMAN » Plexin-C1
MEVSRRKAPP RPPRPAAPLP LLAYLLALAA PGRGADEPVW RSEQAIGAIA ASQEDGVFVA SGSCLDQLDY SLEHSLSRLY RDQAGNCTEP VSLAPPARPR PGSSFSKLLL PYREGAAGLG GLLLTGWTFD RGACEVRPLG NLSRNSLRNG TEVVSCHPQG STAGVVYRAG RNNRWYLAVA ATYVLPEPET ASRCNPAASD HDTAIALKDT EGRSLATQEL GRLKLCEGAG SLHFVDAFLW NGSIYFPYYP YNYTSGAATG WPSMARIAQS TEVLFQGQAS LDCGHGHPDG RRLLLSSSLV EALDVWAGVF SAAAGEGQER RSPTTTALCL FRMSEIQARA KRVSWDFKTA ESHCKEGDQP ERVQPIASST LIHSDLTSVY GTVVMNRTVL FLGTGDGQLL KVILGENLTS NCPEVIYEIK EETPVFYKLV PDPVKNIYIY LTAGKEVRRI RVANCNKHKS CSECLTATDP HCGWCHSLQR CTFQGDCVHS ENLENWLDIS SGAKKCPKIQ IIRSSKEKTT VTMVGSFSPR HSKCMVKNVD SSRELCQNKS QPNRTCTCSI PTRATYKDVS VVNVMFSFGS WNLSDRFNFT NCSSLKECPA CVETGCAWCK SARRCIHPFT ACDPSDYERN QEQCPVAVEK TSGGGRPKEN KGNRTNQALQ VFYIKSIEPQ KVSTLGKSNV IVTGANFTRA SNITMILKGT STCDKDVIQV SHVLNDTHMK FSLPSSRKEM KDVCIQFDGG NCSSVGSLSY IALPHCSLIF PATTWISGGQ NITMMGRNFD VIDNLIISHE LKGNINVSEY CVATYCGFLA PSLKSSKVRT NVTVKLRVQD TYLDCGTLQY REDPRFTGYR VESEVDTELE VKIQKENDNF NISKKDIEIT LFHGENGQLN CSFENITRNQ DLTTILCKIK GIKTASTIAN SSKKVRVKLG NLELYVEQES VPSTWYFLIV LPVLLVIVIF AAVGVTRHKS KELSRKQSQQ LELLESELRK EIRDGFAELQ MDKLDVVDSF GTVPFLDYKH FALRTFFPES GGFTHIFTED MHNRDANDKN ESLTALDALI CNKSFLVTVI HTLEKQKNFS VKDRCLFASF LTIALQTKLV YLTSILEVLT RDLMEQCSNM QPKLMLRRTE SVVEKLLTNW MSVCLSGFLR ETVGEPFYLL VTTLNQKINK GPVDVITCKA LYTLNEDWLL WQVPEFSTVA LNVVFEKIPE NESADVCRNI SVNVLDCDTI GQAKEKIFQA FLSKNGSPYG LQLNEIGLEL QMGTRQKELL DIDSSSVILE DGITKLNTIG HYEISNGSTI KVFKKIANFT SDVEYSDDHC HLILPDSEAF QDVQGKRHRG KHKFKVKEMY LTKLLSTKVA IHSVLEKLFR SIWSLPNSRA PFAIKYFFDF LDAQAENKKI TDPDVVHIWK TNSLPLRFWV NILKNPQFVF DIKKTPHIDG CLSVIAQAFM DAFSLTEQQL GKEAPTNKLL YAKDIPTYKE EVKSYYKAIR DLPPLSSSEM EEFLTQESKK HENEFNEEVA LTEIYKYIVK YFDEILNKLE RERGLEEAQK QLLHVKVLFD EKKKCKWM