PLXB3_HUMAN » Plexin-B3

PLXB3_HUMAN » Plexin-B3
Magnify PLXB3_HUMAN » Plexin-B3Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PLXB3_HUMAN » Plexin-B3 »
Hydrophobic Thickness 28.4 ± 3.6 Å
Tilt Angle 0 ± 0°
ΔGtransfer -39.4 kcal/mol
ΔGfold -18.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 1255-1277 (1253-1279)
Pathways

Axon guidance (KEGG)

Developmental Biology (Reactome)

PDB none
OPM none
Complexes none
Interactions

MET, Complex: MET:PLXB3

RON, Complex: PLXB3:RON, PubMed

SEM4A, Complex: PLXB3:SEM4A, PubMed

Domains

AA: 56-452, PDBID: 3OL2, Subunit B, Seq Identity:53%, Sema domain

AA: 473-526, PDBID: 3OL2, Subunit B, Seq Identity:54%, Plexin repeat

AA: 835-924, PDBID: 2UZX, Subunit B, Seq Identity:26%, IPT/TIG domain

AA: 927-1011, PDBID: 2UZY, Subunit B, Seq Identity:28%, IPT/TIG domain

AA: 1160-1243, PDBID: 3KYA, Subunit A, Seq Identity:23%, IPT/TIG domain

AA: 1327-1876, PDBID: 2JPH, Subunit A, Seq Identity:65%, Plexin cytoplasmic RasGAP domain

UniProt annotation for PLXB3_HUMAN » Plexin-B3
FUNCTION: Receptor for SEMA5A that plays a role in axon guidance, invasive growth and cell migration. Stimulates neurite outgrowth and mediates Ca(2+)/Mg(2+)-dependent cell aggregation. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1.

SUBUNIT: Interacts (via cytoplasmic domain) with RAC1 and ARHGDIA (By similarity). Binds MET and MST1R. Interacts (via cytoplasmic domain) with FSCN1. Interacts with RIT2/RIN. May form homodimers (via Sema domain).

TISSUE SPECIFICITY: Expression detected in Purkinje and granular cells in cerebellum, and in brain neocortex but not in corpus callosum. Expressed in glioma cells and embryonic kidney cells (at protein level). Expressed in brain, liver, pancreas and placenta, with weak expression detected also in lung and kidney. Expressed in several glioma cell lines.

UniProt features for PLXB3_HUMAN » Plexin-B3
SIGNAL 1 44 Potential.
CHAIN 45 1909 Plexin-B3.
DOMAIN 45 471 Sema.
DOMAIN 473 526 PSI 1.
DOMAIN 620 682 PSI 2.
DOMAIN 787 833 PSI 3.
DOMAIN 835 925 IPT/TIG 1.
DOMAIN 927 1012 IPT/TIG 2.
DOMAIN 1015 1145 IPT/TIG 3.
DOMAIN 1159 1244 IPT/TIG 4.
DISULFID 98 107 By similarity.
DISULFID 132 140 By similarity.
DISULFID 267 370 By similarity.
DISULFID 283 315 By similarity.
DISULFID 333 357 By similarity.
DISULFID 474 491 By similarity.
DISULFID 480 525 By similarity.
DISULFID 483 500 By similarity.
DISULFID 494 506 By similarity.
DISULFID 562 580 By similarity.
Amino Acid Sequence for PLXB3_HUMAN » Plexin-B3
MCHAAQETPL LHHFMAPVMA RWPPFGLCLL LLLLSPPPLP LTGAHRFSAP NTTLNHLALA PGRGTLYVGA VNRLFQLSPE LQLEAVAVTG PVIDSPDCVP FRDPAECPQA QLTDNANQLL LVSSRAQELV ACGQVRQGVC ETRRLGDVAE VLYQAEDPGD GQFVAANTPG VATVGLVVPL PGRDLLLVAR GLAGKLSAGV PPLAIRQLAG SQPFSSEGLG RLVVGDFSDY NNSYVGAFAD ARSAYFVFRR RGARAQAEYR SYVARVCLGD TNLYSYVEVP LACQGQGLIQ AAFLAPGTLL GVFAAGPRGT QAALCAFPMV ELGASMEQAR RLCYTAGGRG PSGAEEATVE YGVTSRCVTL PLDSPESYPC GDEHTPSPIA GRQPLEVQPL LKLGQPVSAV AALQADGHMI AFLGDTQGQL YKVFLHGSQG QVYHSQQVGP PGSAISPDLL LDSSGSHLYV LTAHQVDRIP VAACPQFPDC ASCLQAQDPL CGWCVLQGRC TRKGQCGRAG QLNQWLWSYE EDSHCLHIQS LLPGHHPRQE QGQVTLSVPR LPILDADEYF HCAFGDYDSL AHVEGPHVAC VTPPQDQVPL NPPGTDHVTV PLALMFEDVT VAATNFSFYD CSAVQALEAA APCRACVGSI WRCHWCPQSS HCVYGEHCPE GERTIYSAQE VDIQVRGPGA CPQVEGLAGP HLVPVGWESH LALRVRNLQH FRGLPASFHC WLELPGELRG LPATLEETAG DSGLIHCQAH QFYPSMSQRE LPVPIYVTQG EAQRLDNTHA LYVILYDCAM GHPDCSHCQA ANRSLGCLWC ADGQPACRYG PLCPPGAVEL LCPAPSIDAV EPLTGPPEGG LALTILGSNL GRAFADVQYA VSVASRPCNP EPSLYRTSAR IVCVTSPAPN GTTGPVRVAI KSQPPGISSQ HFTYQDPVLL SLSPRWGPQA GGTQLTIRGQ HLQTGGNTSA FVGGQPCPIL EPVCPEAIVC RTRPQAAPGE AAVLVVFGHA QRTLLASPFR YTANPQLVAA EPSASFRGGG RLIRVRGTGL DVVQRPLLSV WLEADAEVQA SRAQPQDPQP RRSCGAPAAD PQACIQLGGG LLQCSTVCSV NSSSLLLCRS PAVPDRAHPQ RVFFTLDNVQ VDFASASGGQ GFLYQPNPRL APLSREGPAR PYRLKPGHVL DVEGEGLNLG ISKEEVRVHI GRGECLVKTL TRTHLYCEPP AHAPQPANGS GLPQFVVQMG NVQLALGPVQ YEAEPPLSAF PVEAQAGVGM GAAVLIAAVL LLTLMYRHKS KQALRDYQKV LVQLESLETG VGDQCRKEFT DLMTEMTDLS SDLEGSGIPF LDYRTYAERA FFPGHGGCPL QPKPEGPGED GHCATVRQGL TQLSNLLNSK LFLLTLIHTL EEQPSFSQRD RCHVASLLSL ALHGKLEYLT DIMRTLLGDL AAHYVHRNPK LMLRRTETMV EKLLTNWLSI CLYAFLREVA GEPLYMLFRA IQYQVDKGPV DAVTGKAKRT LNDSRLLRED VEFQPLTLMV LVGPGAGGAA GSSEMQRVPA RVLDTDTITQ VKEKVLDQVY KGTPFSQRPS VHALDLEWRS GLAGHLTLSD EDLTSVTQNH WKRLNTLQHY KVPDGATVGL VPQLHRGSTI SQSLAQRCPL GENIPTLEDG EEGGVCLWHL VKATEEPEGA KVRCSSLRER EPARAKAIPE IYLTRLLSMK GTLQKFVDDT FQAILSVNRP IPIAVKYLFD LLDELAEKHG IEDPGTLHIW KTNSLLLRFW VNALKNPQLI FDVRVSDNVD AILAVIAQTF IDSCTTSEHK VGRDSPVNKL LYAREIPRYK QMVERYYADI RQSSPASYQE MNSALAELSG NYTSAPHCLE ALQELYNHIH RYYDQIISAL EEDPVGQKLQ LACRLQQVAA LVENKVTDL