PLXB2_HUMAN » Plexin-B2

PLXB2_HUMAN » Plexin-B2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PLXB2_HUMAN » Plexin-B2 » MM1;
Hydrophobic Thickness 34.2 ± 1.2 Å
Tilt Angle 4 ± 11°
ΔGtransfer -26.8 kcal/mol
ΔGfold -17.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 1197-1219 (1195-1224)
Pathways

Axon guidance (KEGG)

PDB 4e71 (A=1452-1562)
OPM none
Complexes none
Interactions

MET, Complex: MET:PLXB2

RON, Complex: PLXB2:RON, PubMed

SEM4A, Complex: SEM4A:PLXB2, PubMed

Domains

AA: 36-447, PDBID: 3OL2, Subunit B, Seq Identity:40%, Sema domain

AA: 468-519, PDBID: 3AL8, Subunit B, Seq Identity:43%, Plexin repeat

AA: 803-892, PDBID: 1HK6, Subunit A, Seq Identity:25%, IPT/TIG domain

AA: 895-979, PDBID: 2UZY, Subunit B, Seq Identity:31%, IPT/TIG domain

AA: 983-1091, PDBID: 3MUJ, Subunit A, Seq Identity:15%, IPT/TIG domain

AA: 1271-1805, PDBID: 4E71, Subunit A, Seq Identity:100%, Plexin cytoplasmic RasGAP domain

UniProt annotation for PLXB2_HUMAN » Plexin-B2
FUNCTION: Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at "Tyr-1248". Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development. Regulates the migration of cerebellar granule cells in the developing brain. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May modulate the activity of RAC1 and CDC42. Down-regulates macrophage migration in wound- healing assays (in vitro) (By similarity).

SUBUNIT: Monomer, and heterodimer with PLXNB1. Interacts with SEMA4C, SEMA4D and SEMA4G (By similarity). Binds MET, ARHGEF11 and ARHGEF12. May also interact with MST1R.

UniProt features for PLXB2_HUMAN » Plexin-B2
SIGNAL 1 19 Potential.
CHAIN 20 1838 Plexin-B2.
DOMAIN 20 466 Sema.
DOMAIN 803 893 IPT/TIG 1.
DOMAIN 895 980 IPT/TIG 2.
DOMAIN 983 1092 IPT/TIG 3.
SITE 1164 1165 Cleavage; by proprotein convertases.
DISULFID 78 87 By similarity.
DISULFID 112 120 By similarity.
DISULFID 250 364 By similarity.
DISULFID 266 312 By similarity.
DISULFID 330 351 By similarity.
DISULFID 469 486 By similarity.
DISULFID 475 518 By similarity.
DISULFID 478 495 By similarity.
DISULFID 489 501 By similarity.
DISULFID 555 574 By similarity.
Amino Acid Sequence for PLXB2_HUMAN » Plexin-B2
MALQLWALTL LGLLGAGASL RPRKLDFFRS EKELNHLAVD EASGVVYLGA VNALYQLDAK LQLEQQVATG PALDNKKCTP PIEASQCHEA EMTDNVNQLL LLDPPRKRLV ECGSLFKGIC ALRALSNISL RLFYEDGSGE KSFVASNDEG VATVGLVSST GPGGDRVLFV GKGNGPHDNG IIVSTRLLDR TDSREAFEAY TDHATYKAGY LSTNTQQFVA AFEDGPYVFF VFNQQDKHPA RNRTLLARMC REDPNYYSYL EMDLQCRDPD IHAAAFGTCL AASVAAPGSG RVLYAVFSRD SRSSGGPGAG LCLFPLDKVH AKMEANRNAC YTGTREARDI FYKPFHGDIQ CGGHAPGSSK SFPCGSEHLP YPLGSRDGLR GTAVLQRGGL NLTAVTVAAE NNHTVAFLGT SDGRILKVYL TPDGTSSEYD SILVEINKRV KRDLVLSGDL GSLYAMTQDK VFRLPVQECL SYPTCTQCRD SQDPYCGWCV VEGRCTRKAE CPRAEEASHW LWSRSKSCVA VTSAQPQNMS RRAQGEVQLT VSPLPALSEE DELLCLFGES PPHPARVEGE AVICNSPSSI PVTPPGQDHV AVTIQLLLRR GNIFLTSYQY PFYDCRQAMS LEENLPCISC VSNRWTCQWD LRYHECREAS PNPEDGIVRA HMEDSCPQFL GPSPLVIPMN HETDVNFQGK NLDTVKGSSL HVGSDLLKFM EPVTMQESGT FAFRTPKLSH DANETLPLHL YVKSYGKNID SKLHVTLYNC SFGRSDCSLC RAANPDYRCA WCGGQSRCVY EALCNTTSEC PPPVITRIQP ETGPLGGGIR ITILGSNLGV QAGDIQRISV AGRNCSFQPE RYSVSTRIVC VIEAAETPFT GGVEVDVFGK LGRSPPNVQF TFQQPKPLSV EPQQGPQAGG TTLTIHGTHL DTGSQEDVRV TLNGVPCKVT KFGAQLQCVT GPQATRGQML LEVSYGGSPV PNPGIFFTYR ENPVLRAFEP LRSFASGGRS INVTGQGFSL IQRFAMVVIA EPLQSWQPPR EAESLQPMTV VGTDYVFHND TKVVFLSPAV PEEPEAYNLT VLIEMDGHRA LLRTEAGAFE YVPDPTFENF TGGVKKQVNK LIHARGTNLN KAMTLQEAEA FVGAERCTMK TLTETDLYCE PPEVQPPPKR RQKRDTTHNL PEFIVKFGSR EWVLGRVEYD TRVSDVPLSL ILPLVIVPMV VVIAVSVYCY WRKSQQAERE YEKIKSQLEG LEESVRDRCK KEFTDLMIEM EDQTNDVHEA GIPVLDYKTY TDRVFFLPSK DGDKDVMITG KLDIPEPRRP VVEQALYQFS NLLNSKSFLI NFIHTLENQR EFSARAKVYF ASLLTVALHG KLEYYTDIMH TLFLELLEQY VVAKNPKLML RRSETVVERM LSNWMSICLY QYLKDSAGEP LYKLFKAIKH QVEKGPVDAV QKKAKYTLND TGLLGDDVEY APLTVSVIVQ DEGVDAIPVK VLNCDTISQV KEKIIDQVYR GQPCSCWPRP DSVVLEWRPG STAQILSDLD LTSQREGRWK RVNTLMHYNV RDGATLILSK VGVSQQPEDS QQDLPGERHA LLEEENRVWH LVRPTDEVDE GKSKRGSVKE KERTKAITEI YLTRLLSVKG TLQQFVDNFF QSVLAPGHAV PPAVKYFFDF LDEQAEKHNI QDEDTIHIWK TNSLPLRFWV NILKNPHFIF DVHVHEVVDA SLSVIAQTFM DACTRTEHKL SRDSPSNKLL YAKEISTYKK MVEDYYKGIR QMVQVSDQDM NTHLAEISRA HTDSLNTLVA LHQLYQYTQK YYDEIINALE EDPAAQKMQL AFRLQQIAAA LENKVTDL