PLXB1_HUMAN » Plexin-B1

PLXB1_HUMAN » Plexin-B1
Magnify PLXB1_HUMAN » Plexin-B1Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PLXB1_HUMAN » Plexin-B1 » Semaphorin receptor SEP;
Hydrophobic Thickness 34.0 ± 1.4 Å
Tilt Angle 0 ± 0°
ΔGtransfer -38.6 kcal/mol
ΔGfold -15.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 1492-1513 (1486-1514)
Pathways

Axon guidance (KEGG)

Developmental Biology (Reactome)

Signal Transduction (Reactome)

PDB 2jph (1743-1862), 2r2o (A/B=1743-1862), 2rex (A/C=1743-1862), 3ol2 (B=20-535), 2os6 (B=2128-2135), 3sua (D/E/F=1511-2135), 3hm6 (X=1511-2135), 3su8 (X=1533-2135)
OPM none
Complexes

SEM4D:PLXB1_HUMAN

PLXB1:PLXB1_HUMAN

Interactions

ERBB2, Complex: ERBB2:PLXB1, PubMed

MET, Complex: PLXB1:MET, PubMed

PLXA1, Complex: PLXA1:PLXB1, PubMed

PLXB1, Complex: Homodimer of plexin-B1, PDBID: 2R2O

RON, Complex: PLXB1:RON, PubMed

SEM4A, Complex: PLXB1:SEM4A, PubMed

SEM4B, Complex: PLXB1:SEM4B, PubMed

SEM4D, Complex: SEM4D:PLXB1, PDBID: 3OL2, PubMed

Domains

AA: 37-460, PDBID: 3OL2, Subunit B, Seq Identity:100%, Sema domain

AA: 481-534, PDBID: 3OL2, Subunit B, Seq Identity:100%, Plexin repeat

AA: 1070-1159, PDBID: 1HK6, Subunit A, Seq Identity:30%, IPT/TIG domain

AA: 1162-1248, PDBID: 2UZX, Subunit B, Seq Identity:26%, IPT/TIG domain

AA: 1252-1374, PDBID: 3MLP, Subunit E, Seq Identity:14%, IPT/TIG domain

AA: 1562-2102, PDBID: 2JPH, Subunit A, Seq Identity:100%, Plexin cytoplasmic RasGAP domain

UniProt annotation for PLXB1_HUMAN » Plexin-B1
FUNCTION: Receptor for SEMA4D. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration.

SUBUNIT: Monomer, and heterodimer with PLXNB2 after proteolytic processing. Binds RAC1 that has been activated by GTP binding. Interaction with SEMA4D promotes binding of cytoplasmic ligands. Binds PLXNA1 (By similarity). Interacts with ARHGEF11, ARHGEF12, ERBB2, MET, MST1R, RRAS, RHOD, RND1, NRP1 and NRP2.

TISSUE SPECIFICITY: Highly expressed in fetal kidney, and at slightly lower levels in fetal brain, lung and liver.

UniProt features for PLXB1_HUMAN » Plexin-B1
SIGNAL 1 19 Potential.
CHAIN 20 2135 Plexin-B1.
DOMAIN 20 479 Sema.
DOMAIN 1070 1160 IPT/TIG 1.
DOMAIN 1162 1249 IPT/TIG 2.
DOMAIN 1252 1375 IPT/TIG 3.
COILED 1507 1539 Potential.
SITE 1305 1306 Cleavage; by proprotein convertases.
SITE 1815 1815 Important for interaction with RAC1 and RND1.
DISULFID 79 88 By similarity.
DISULFID 111 119 By similarity.
DISULFID 252 377 By similarity.
DISULFID 268 322 By similarity.
DISULFID 340 364 By similarity.
DISULFID 482 499 By similarity.
DISULFID 488 533 By similarity.
DISULFID 491 508 By similarity.
DISULFID 502 514 By similarity.
DISULFID 570 588 By similarity.
Amino Acid Sequence for PLXB1_HUMAN » Plexin-B1
MPALGPALLQ ALWAGWVLTL QPLPPTAFTP NGTYLQHLAR DPTSGTLYLG ATNFLFQLSP GLQLEATVST GPVLDSRDCL PPVMPDECPQ AQPTNNPNQL LLVSPGALVV CGSVHQGVCE QRRLGQLEQL LLRPERPGDT QYVAANDPAV STVGLVAQGL AGEPLLFVGR GYTSRGVGGG IPPITTRALW PPDPQAAFSY EETAKLAVGR LSEYSHHFVS AFARGASAYF LFLRRDLQAQ SRAFRAYVSR VCLRDQHYYS YVELPLACEG GRYGLIQAAA VATSREVAHG EVLFAAFSSA APPTVGRPPS AAAGASGASA LCAFPLDEVD RLANRTRDAC YTREGRAEDG TEVAYIEYDV NSDCAQLPVD TLDAYPCGSD HTPSPMASRV PLEATPILEW PGIQLTAVAV TMEDGHTIAF LGDSQGQLHR VYLGPGSDGH PYSTQSIQQG SAVSRDLTFD GTFEHLYVMT QSTLLKVPVA SCAQHLDCAS CLAHRDPYCG WCVLLGRCSR RSECSRGQGP EQWLWSFQPE LGCLQVAAMS PANISREETR EVFLSVPDLP PLWPGESYSC HFGEHQSPAL LTGSGVMCPS PDPSEAPVLP RGADYVSVSV ELRFGAVVIA KTSLSFYDCV AVTELRPSAQ CQACVSSRWG CNWCVWQHLC THKASCDAGP MVASHQSPLV SPDPPARGGP SPSPPTAPKA LATPAPDTLP VEPGAPSTAT ASDISPGASP SLLSPWGPWA GSGSISSPGS TGSPLHEEPS PPSPQNGPGT AVPAPTDFRP SATPEDLLAS PLSPSEVAAV PPADPGPEAL HPTVPLDLPP ATVPATTFPG AMGSVKPALD WLTREGGELP EADEWTGGDA PAFSTSTLLS GDGDSAELEG PPAPLILPSS LDYQYDTPGL WELEEATLGA SSCPCVESVQ GSTLMPVHVE REIRLLGRNL HLFQDGPGDN ECVMELEGLE VVVEARVECE PPPDTQCHVT CQQHQLSYEA LQPELRVGLF LRRAGRLRVD SAEGLHVVLY DCSVGHGDCS RCQTAMPQYG CVWCEGERPR CVTREACGEA EAVATQCPAP LIHSVEPLTG PVDGGTRVTI RGSNLGQHVQ DVLGMVTVAG VPCAVDAQEY EVSSSLVCIT GASGEEVAGA TAVEVPGRGR GVSEHDFAYQ DPKVHSIFPA RGPRAGGTRL TLNGSKLLTG RLEDIRVVVG DQPCHLLPEQ QSEQLRCETS PRPTPATLPV AVWFGATERR LQRGQFKYTL DPNITSAGPT KSFLSGGREI CVRGQNLDVV QTPRIRVTVV SRMLQPSQGL GRRRRVVPET ACSLGPSCSS QQFEEPCHVN SSQLITCRTP ALPGLPEDPW VRVEFILDNL VFDFATLNPT PFSYEADPTL QPLNPEDPTM PFRHKPGSVF SVEGENLDLA MSKEEVVAMI GDGPCVVKTL TRHHLYCEPP VEQPLPRHHA LREAPDSLPE FTVQMGNLRF SLGHVQYDGE SPGAFPVAAQ VGLGVGTSLL ALGVIIIVLM YRRKSKQALR DYKKVQIQLE NLESSVRDRC KKEFTDLMTE MTDLTSDLLG SGIPFLDYKV YAERIFFPGH RESPLHRDLG VPESRRPTVE QGLGQLSNLL NSKLFLTKFI HTLESQRTFS ARDRAYVASL LTVALHGKLE YFTDILRTLL SDLVAQYVAK NPKLMLRRTE TVVEKLLTNW MSICLYTFVR DSVGEPLYML FRGIKHQVDK GPVDSVTGKA KYTLNDNRLL REDVEYRPLT LNALLAVGPG AGEAQGVPVK VLDCDTISQA KEKMLDQLYK GVPLTQRPDP RTLDVEWRSG VAGHLILSDE DVTSEVQGLW RRLNTLQHYK VPDGATVALV PCLTKHVLRE NQDYVPGERT PMLEDVDEGG IRPWHLVKPS DEPEPPRPRR GSLRGGERER AKAIPEIYLT RLLSMKGTLQ KFVDDLFQVI LSTSRPVPLA VKYFFDLLDE QAQQHGISDQ DTIHIWKTNS LPLRFWINII KNPQFVFDVQ TSDNMDAVLL VIAQTFMDAC TLADHKLGRD SPINKLLYAR DIPRYKRMVE RYYADIRQTV PASDQEMNSV LAELSWNYSG DLGARVALHE LYKYINKYYD QIITALEEDG TAQKMQLGYR LQQIAAAVEN KVTDL