PLXA4_HUMAN » Plexin-A4

PLXA4_HUMAN » Plexin-A4
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PLXA4_HUMAN » Plexin-A4 »
Hydrophobic Thickness 33.2 ± 3.8 Å
Tilt Angle 0 ± 2°
ΔGtransfer -46.7 kcal/mol
ΔGfold -24.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 1236-1261 (1236-1266)
Pathways

Developmental Biology (Reactome)

PDB 4e74 (A=1488-1603)
OPM none
Complexes none
Interactions

NRP1, Complex: NRP1:PLXA4:FARP2

Domains

AA: 53-488, PDBID: 3AL8, Subunit B, Seq Identity:53%, Sema domain

AA: 509-559, PDBID: 3AL8, Subunit B, Seq Identity:62%, Plexin repeat

AA: 655-703, PDBID: 3AFC, Subunit B, Seq Identity:29%, Plexin repeat

AA: 858-951, PDBID: 1UAD, Subunit D, Seq Identity:28%, IPT/TIG domain

AA: 954-1036, PDBID: 2UZY, Subunit B, Seq Identity:26%, IPT/TIG domain

AA: 1040-1138, PDBID: 3KYA, Subunit A, Seq Identity:17%, IPT/TIG domain

AA: 1142-1227, PDBID: 2UZY, Subunit B, Seq Identity:25%, IPT/TIG domain

AA: 1311-1864, PDBID: 4E74, Subunit A, Seq Identity:100%, Plexin cytoplasmic RasGAP domain

UniProt annotation for PLXA4_HUMAN » Plexin-A4
FUNCTION: Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).

SUBUNIT: Interacts with NRP1 and NRP2.

UniProt features for PLXA4_HUMAN » Plexin-A4
SIGNAL 1 23 Potential.
CHAIN 24 1894 Plexin-A4.
DOMAIN 24 507 Sema.
DOMAIN 509 559 PSI 1.
DOMAIN 655 702 PSI 2.
DOMAIN 803 856 PSI 3.
DOMAIN 858 952 IPT/TIG 1.
DOMAIN 954 1037 IPT/TIG 2.
DOMAIN 1040 1139 IPT/TIG 3.
DOMAIN 1142 1230 IPT/TIG 4.
DISULFID 95 104 By similarity.
DISULFID 130 138 By similarity.
DISULFID 284 405 By similarity.
DISULFID 300 356 By similarity.
DISULFID 374 393 By similarity.
DISULFID 510 527 By similarity.
DISULFID 516 558 By similarity.
DISULFID 519 536 By similarity.
DISULFID 530 542 By similarity.
DISULFID 593 612 By similarity.
Amino Acid Sequence for PLXA4_HUMAN » Plexin-A4
MKAMPWNWTC LLSHLLMVGM GSSTLLTRQP APLSQKQRSF VTFRGEPAEG FNHLVVDERT GHIYLGAVNR IYKLSSDLKV LVTHETGPDE DNPKCYPPRI VQTCNEPLTT TNNVNKMLLI DYKENRLIAC GSLYQGICKL LRLEDLFKLG EPYHKKEHYL SGVNESGSVF GVIVSYSNLD DKLFIATAVD GKPEYFPTIS SRKLTKNSEA DGMFAYVFHD EFVASMIKIP SDTFTIIPDF DIYYVYGFSS GNFVYFLTLQ PEMVSPPGST TKEQVYTSKL VRLCKEDTAF NSYVEVPIGC ERSGVEYRLL QAAYLSKAGA VLGRTLGVHP DDDLLFTVFS KGQKRKMKSL DESALCIFIL KQINDRIKER LQSCYRGEGT LDLAWLKVKD IPCSSALLTI DDNFCGLDMN APLGVSDMVR GIPVFTEDRD RMTSVIAYVY KNHSLAFVGT KSGKLKKIRV DGPRGNALQY ETVQVVDPGP VLRDMAFSKD HEQLYIMSER QLTRVPVESC GQYQSCGECL GSGDPHCGWC VLHNTCTRKE RCERSKEPRR FASEMKQCVR LTVHPNNISV SQYNVLLVLE TYNVPELSAG VNCTFEDLSE MDGLVVGNQI QCYSPAAKEV PRIITENGDH HVVQLQLKSK ETGMTFASTS FVFYNCSVHN SCLSCVESPY RCHWCKYRHV CTHDPKTCSF QEGRVKLPED CPQLLRVDKI LVPVEVIKPI TLKAKNLPQP QSGQRGYECI LNIQGSEQRV PALRFNSSSV QCQNTSYSYE GMEINNLPVE LTVVWNGHFN IDNPAQNKVH LYKCGAMRES CGLCLKADPD FACGWCQGPG QCTLRQHCPA QESQWLELSG AKSKCTNPRI TEIIPVTGPR EGGTKVTIRG ENLGLEFRDI ASHVKVAGVE CSPLVDGYIP AEQIVCEMGE AKPSQHAGFV EICVAVCRPE FMARSSQLYY FMTLTLSDLK PSRGPMSGGT QVTITGTNLN AGSNVVVMFG KQPCLFHRRS PSYIVCNTTS SDEVLEMKVS VQVDRAKIHQ DLVFQYVEDP TIVRIEPEWS IVSGNTPIAV WGTHLDLIQN PQIRAKHGGK EHINICEVLN ATEMTCQAPA LALGPDHQSD LTERPEEFGF ILDNVQSLLI LNKTNFTYYP NPVFEAFGPS GILELKPGTP IILKGKNLIP PVAGGNVKLN YTVLVGEKPC TVTVSDVQLL CESPNLIGRH KVMARVGGME YSPGMVYIAP DSPLSLPAIV SIAVAGGLLI IFIVAVLIAY KRKSRESDLT LKRLQMQMDN LESRVALECK EAFAELQTDI HELTSDLDGA GIPFLDYRTY TMRVLFPGIE DHPVLRDLEV PGYRQERVEK GLKLFAQLIN NKVFLLSFIR TLESQRSFSM RDRGNVASLI MTVLQSKLEY ATDVLKQLLA DLIDKNLESK NHPKLLLRRT ESVAEKMLTN WFTFLLYKFL KECAGEPLFS LFCAIKQQME KGPIDAITGE ARYSLSEDKL IRQQIDYKTL VLSCVSPDNA NSPEVPVKIL NCDTITQVKE KILDAIFKNV PCSHRPKAAD MDLEWRQGSG ARMILQDEDI TTKIENDWKR LNTLAHYQVP DGSVVALVSK QVTAYNAVNN STVSRTSASK YENMIRYTGS PDSLRSRTPM ITPDLESGVK MWHLVKNHEH GDQKEGDRGS KMVSEIYLTR LLATKGTLQK FVDDLFETIF STAHRGSALP LAIKYMFDFL DEQADKHGIH DPHVRHTWKS NCLPLRFWVN MIKNPQFVFD IHKNSITDAC LSVVAQTFMD SCSTSEHRLG KDSPSNKLLY AKDIPSYKNW VERYYSDIGK MPAISDQDMN AYLAEQSRMH MNEFNTMSAL SEIFSYVGKY SEEILGPLDH DDQCGKQKLA YKLEQVITLM SLDS