PLXA3_HUMAN » Plexin-A3

PLXA3_HUMAN » Plexin-A3
Magnify PLXA3_HUMAN » Plexin-A3Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PLXA3_HUMAN » Plexin-A3 » Plexin-4;Semaphorin receptor SEX;
Hydrophobic Thickness 34.0 ± 1.4 Å
Tilt Angle 0 ± 0°
ΔGtransfer -39.1 kcal/mol
ΔGfold -20.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 1216-1243 (1211-1246)
Pathways

Axon guidance (KEGG)

Developmental Biology (Reactome)

PDB none
OPM none
Complexes none
Interactions

NRP1, Complex: NRP1:PLXA3:FARP2

Domains

AA: 35-469, PDBID: 3AL8, Subunit B, Seq Identity:48%, Sema domain

AA: 490-540, PDBID: 3AL8, Subunit B, Seq Identity:37%, Plexin repeat

AA: 637-685, PDBID: 3NVQ, Subunit A, Seq Identity:25%, Plexin repeat

AA: 840-932, PDBID: 1UAD, Subunit D, Seq Identity:30%, IPT/TIG domain

AA: 935-1019, PDBID: 2UZY, Subunit B, Seq Identity:24%, IPT/TIG domain

AA: 1023-1121, PDBID: 1HK6, Subunit A, Seq Identity:15%, IPT/TIG domain

AA: 1126-1210, PDBID: 2UZY, Subunit B, Seq Identity:27%, IPT/TIG domain

AA: 1293-1841, PDBID: 3IG3, Subunit A, Seq Identity:98%, Plexin cytoplasmic RasGAP domain

UniProt annotation for PLXA3_HUMAN » Plexin-A3
FUNCTION: Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.

SUBUNIT: Interacts with CBFA2T3/MTG16.

UniProt features for PLXA3_HUMAN » Plexin-A3
SIGNAL 1 19 Potential.
CHAIN 20 1871 Plexin-A3.
DOMAIN 20 488 Sema.
DOMAIN 840 933 IPT/TIG 1.
DOMAIN 935 1020 IPT/TIG 2.
DOMAIN 1023 1122 IPT/TIG 3.
DOMAIN 1125 1211 IPT/TIG 4.
DISULFID 77 86 By similarity.
DISULFID 112 120 By similarity.
DISULFID 266 387 By similarity.
DISULFID 282 338 By similarity.
DISULFID 356 375 By similarity.
DISULFID 491 508 By similarity.
DISULFID 497 539 By similarity.
DISULFID 500 517 By similarity.
DISULFID 511 523 By similarity.
DISULFID 574 594 By similarity.
Amino Acid Sequence for PLXA3_HUMAN » Plexin-A3
MPSVCLLLLL FLAVGGALGN RPFRAFVVTD TTLTHLAVHR VTGEVFVGAV NRVFKLAPNL TELRAHVTGP VEDNARCYPP PSMRVCAHRL APVDNINKLL LIDYAARRLV ACGSIWQGIC QFLRLDDLFK LGEPHHRKEH YLSGAQEPDS MAGVIVEQGQ GPSKLFVGTA VDGKSEYFPT LSSRKLISDE DSADMFSLVY QDEFVSSQIK IPSDTLSLYP AFDIYYIYGF VSASFVYFLT LQLDTQQTLL DTAGEKFFTS KIVRMCAGDS EFYSYVEFPI GCSWRGVEYR LVQSAHLAKP GLLLAQALGV PADEDVLFTI FSQGQKNRAS PPRQTILCLF TLSNINAHIR RRIQSCYRGE GTLALPWLLN KELPCINTPM QINGNFCGLV LNQPLGGLHV IEGLPLLADS TDGMASVAAY TYRQHSVVFI GTRSGSLKKV RVDGFQDAHL YETVPVVDGS PILRDLLFSP DHRHIYLLSE KQVSQLPVET CEQYQSCAAC LGSGDPHCGW CVLRHRCCRE GACLGASAPH GFAEELSKCV QVRVRPNNVS VTSPGVQLTV TLHNVPDLSA GVSCAFEAAA ENEAVLLPSG ELLCPSPSLQ ELRALTRGHG ATRTVRLQLL SKETGVRFAG ADFVFYNCSV LQSCMSCVGS PYPCHWCKYR HTCTSRPHEC SFQEGRVHSP EGCPEILPSG DLLIPVGVMQ PLTLRAKNLP QPQSGQKNYE CVVRVQGRQQ RVPAVRFNSS SVQCQNASYS YEGDEHGDTE LDFSVVWDGD FPIDKPPSFR ALLYKCWAQR PSCGLCLKAD PRFNCGWCIS EHRCQLRTHC PAPKTNWMHL SQKGTRCSHP RITQIHPLVG PKEGGTRVTI VGDNLGLLSR EVGLRVAGVR CNSIPAEYIS AERIVCEMEE SLVPSPPPGP VELCVGDCSA DFRTQSEQVY SFVTPTFDQV SPSRGPASGG TRLTISGSSL DAGSRVTVTV RDSECQFVRR DAKAIVCISP LSTLGPSQAP ITLAIDRANI SSPGLIYTYT QDPTVTRLEP TWSIINGSTA ITVSGTHLLT VQEPRVRAKY RGIETTNTCQ VINDTAMLCK APGIFLGRPQ PRAQGEHPDE FGFLLDHVQT ARSLNRSSFT YYPDPSFEPL GPSGVLDVKP GSHVVLKGKN LIPAAAGSSR LNYTVLIGGQ PCSLTVSDTQ LLCDSPSQTG RQPVMVLVGG LEFWLGTLHI SAERALTLPA MMGLAAGGGL LLLAITAVLV AYKRKTQDAD RTLKRLQLQM DNLESRVALE CKEAFAELQT DINELTNHMD EVQIPFLDYR TYAVRVLFPG IEAHPVLKEL DTPPNVEKAL RLFGQLLHSR AFVLTFIHTL EAQSSFSMRD RGTVASLTMV ALQSRLDYAT GLLKQLLADL IEKNLESKNH PKLLLRRTES VAEKMLTNWF TFLLHKFLKE CAGEPLFLLY CAIKQQMEKG PIDAITGEAR YSLSEDKLIR QQIDYKTLTL HCVCPENEGS AQVPVKVLNC DSITQAKDKL LDTVYKGIPY SQRPKAEDMD LEWRQGRMTR IILQDEDVTT KIECDWKRLN SLAHYQVTDG SLVALVPKQV SAYNMANSFT FTRSLSRYES LLRTASSPDS LRSRAPMITP DQETGTKLWH LVKNHDHADH REGDRGSKMV SEIYLTRLLA TKGTLQKFVD DLFETVFSTA HRGSALPLAI KYMFDFLDEQ ADQRQISDPD VRHTWKSNCL PLRFWVNVIK NPQFVFDIHK NSITDACLSV VAQTFMDSCS TSEHRLGKDS PSNKLLYAKD IPNYKSWVER YYRDIAKMAS ISDQDMDAYL VEQSRLHASD FSVLSALNEL YFYVTKYRQE ILTALDRDAS CRKHKLRQKL EQIISLVSSD S