PLXA2_HUMAN » Plexin-A2

PLXA2_HUMAN » Plexin-A2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PLXA2_HUMAN » Plexin-A2 » Semaphorin receptor OCT;
Hydrophobic Thickness 41.2 ± 1.2 Å
Tilt Angle 0 ± 1°
ΔGtransfer -47.1 kcal/mol
ΔGfold -24.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 1234-1261 (1231-1266)
Pathways

Axon guidance (KEGG)

Developmental Biology (Reactome)

PDB 3q3j (A=1490-1600)
OPM none
Complexes

SEM6A:PLXA2_MOUSE

SEM3A:PLXA2:NRP1_MOUSE

PLXA2:PLXA2_MOUSE

Interactions

NRP1, Complex: NRP1:PLXA2, PubMed

NRP1, Complex: PLXA2:NRP1:FARP2

NRP1, Complex: SEM3A:PLXA2:NRP1, PDBID: 4GZA

PLXA2, Complex: Homodimer of plexin-A2, PDBID: 3AL9

SEM6A, Complex: SEM6A:PLXA2, PDBID: 3AL8

Domains

AA: 52-489, PDBID: 3AL8, Subunit B, Seq Identity:98%, Sema domain

AA: 510-560, PDBID: 3AL8, Subunit B, Seq Identity:94%, Plexin repeat

AA: 858-951, PDBID: 1UAD, Subunit D, Seq Identity:25%, IPT/TIG domain

AA: 954-1037, PDBID: 2UZY, Subunit B, Seq Identity:28%, IPT/TIG domain

AA: 1041-1139, PDBID: 3KYA, Subunit A, Seq Identity:19%, IPT/TIG domain

AA: 1143-1228, PDBID: 2UZY, Subunit B, Seq Identity:23%, IPT/TIG domain

AA: 1311-1864, PDBID: 3Q3J, Subunit A, Seq Identity:100%, Plexin cytoplasmic RasGAP domain

UniProt annotation for PLXA2_HUMAN » Plexin-A2
FUNCTION: Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down- stream signaling events in the cytoplasm (By similarity).

SUBUNIT: Homodimer. The PLXNA2 homodimer interacts with a SEMA6A homodimer, giving rise to a heterotetramer. Interacts directly with NRP1 and NRP2 (By similarity). Interacts with RND1.

TISSUE SPECIFICITY: Detected in fetal brain.

UniProt features for PLXA2_HUMAN » Plexin-A2
SIGNAL 1 34 Potential.
CHAIN 35 1894 Plexin-A2.
DOMAIN 35 508 Sema.
DOMAIN 858 951 IPT/TIG 1.
DOMAIN 954 1037 IPT/TIG 2.
DOMAIN 1041 1139 IPT/TIG 3.
DOMAIN 1143 1228 IPT/TIG 4.
COILED 1261 1310 Potential.
DISULFID 94 103 By similarity.
DISULFID 129 137 By similarity.
DISULFID 284 405 By similarity.
DISULFID 300 356 By similarity.
DISULFID 374 393 By similarity.
DISULFID 511 528 By similarity.
DISULFID 517 559 By similarity.
DISULFID 520 537 By similarity.
DISULFID 531 543 By similarity.
DISULFID 594 613 By similarity.
Amino Acid Sequence for PLXA2_HUMAN » Plexin-A2
MEQRRPWPRA LEVDSRSVVL LSVVWVLLAP PAAGMPQFST FHSENRDWTF NHLTVHQGTG AVYVGAINRV YKLTGNLTIQ VAHKTGPEED NKSCYPPLIV QPCSEVLTLT NNVNKLLIID YSENRLLACG SLYQGVCKLL RLDDLFILVE PSHKKEHYLS SVNKTGTMYG VIVRSEGEDG KLFIGTAVDG KQDYFPTLSS RKLPRDPESS AMLDYELHSD FVSSLIKIPS DTLALVSHFD IFYIYGFASG GFVYFLTVQP ETPEGVAINS AGDLFYTSRI VRLCKDDPKF HSYVSLPFGC TRAGVEYRLL QAAYLAKPGD SLAQAFNITS QDDVLFAIFS KGQKQYHHPP DDSALCAFPI RAINLQIKER LQSCYQGEGN LELNWLLGKD VQCTKAPVPI DDNFCGLDIN QPLGGSTPVE GLTLYTTSRD RMTSVASYVY NGYSVVFVGT KSGKLKKIRA DGPPHGGVQY EMVSVLKDGS PILRDMAFSI DQRYLYVMSE RQVTRVPVES CEQYTTCGEC LSSGDPHCGW CALHNMCSRR DKCQQAWEPN RFAASISQCV SLAVHPSSIS VSEHSRLLSL VVSDAPDLSA GIACAFGNLT EVEGQVSGSQ VICISPGPKD VPVIPLDQDW FGLELQLRSK ETGKIFVSTE FKFYNCSAHQ LCLSCVNSAF RCHWCKYRNL CTHDPTTCSF QEGRINISED CPQLVPTEEI LIPVGEVKPI TLKARNLPQP QSGQRGYECV LNIQGAIHRV PALRFNSSSV QCQNSSYQYD GMDISNLAVD FAVVWNGNFI IDNPQDLKVH LYKCAAQRES CGLCLKADRK FECGWCSGER RCTLHQHCTS PSSPWLDWSS HNVKCSNPQI TEILTVSGPP EGGTRVTIHG VNLGLDFSEI AHHVQVAGVP CTPLPGEYII AEQIVCEMGH ALVGTTSGPV RLCIGECKPE FMTKSHQQYT FVNPSVLSLN PIRGPESGGT MVTITGHYLG AGSSVAVYLG NQTCEFYGRS MSEIVCVSPP SSNGLGPVPV SVSVDRAHVD SNLQFEYIDD PRVQRIEPEW SIASGHTPLT ITGFNLDVIQ EPRIRVKFNG KESVNVCKVV NTTTLTCLAP SLTTDYRPGL DTVERPDEFG FVFNNVQSLL IYNDTKFIYY PNPTFELLSP TGVLDQKPGS PIILKGKNLC PPASGGAKLN YTVLIGETPC AVTVSETQLL CEPPNLTGQH KVMVHVGGMV FSPGSVSVIS DSLLTLPAIV SIAAGGSLLL IIVIIVLIAY KRKSRENDLT LKRLQMQMDN LESRVALECK EAFAELQTDI NELTSDLDRS GIPYLDYRTY AMRVLFPGIE DHPVLRELEV QGNGQQHVEK ALKLFAQLIN NKVFLLTFIR TLELQRSFSM RDRGNVASLI MTGLQGRLEY ATDVLKQLLS DLIDKNLENK NHPKLLLRRT ESVAEKMLTN WFAFLLHKFL KECAGEPLFM LYCAIKQQME KGPIDAITGE ARYSLSEDKL IRQQIEYKTL ILNCVNPDNE NSPEIPVKVL NCDTITQVKE KILDAVYKNV PYSQRPRAVD MDLEWRQGRI ARVVLQDEDI TTKIEGDWKR LNTLMHYQVS DRSVVALVPK QTSSYNIPAS ASISRTSISR YDSSFRYTGS PDSLRSRAPM ITPDLESGVK VWHLVKNHDH GDQKEGDRGS KMVSEIYLTR LLATKGTLQK FVDDLFETLF STVHRGSALP LAIKYMFDFL DEQADRHSIH DTDVRHTWKS NCLPLRFWVN VIKNPQFVFD IHKGSITDAC LSVVAQTFMD SCSTSEHRLG KDSPSNKLLY AKDIPSYKSW VERYYADIAK LPAISDQDMN AYLAEQSRLH AVEFNMLSAL NEIYSYVSKY SEELIGALEQ DEQARRQRLA YKVEQLINAM SIES