PLXA1_HUMAN » Plexin-A1

PLXA1_HUMAN » Plexin-A1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PLXA1_HUMAN » Plexin-A1 » Semaphorin receptor NOV;
Hydrophobic Thickness 42.8 ± 4.2 Å
Tilt Angle 11 ± 8°
ΔGtransfer -26.4 kcal/mol
ΔGfold -17.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 1239-1268 (1236-1271)
Pathways

Axon guidance (KEGG)

Developmental Biology (Reactome)

PDB none
OPM none
Complexes none
Interactions

NRP1, Complex: PLXA1:FARP2:NRP1

NRP1, Complex: PLXA1:NRP1, PubMed

NRP1, Complex: PLXA1:SEM6D:NRP1

PLXB1, Complex: PLXA1:PLXB1, PubMed

SEM6D, Complex: PLXA1:SEM6D, PubMed

VGFR2, Complex: VGFR2:PLXA1, PubMed

Domains

AA: 53-493, PDBID: 3AL8, Subunit B, Seq Identity:48%, Sema domain

AA: 514-564, PDBID: 3AL8, Subunit B, Seq Identity:60%, Plexin repeat

AA: 808-862, PDBID: 1SHY, Subunit B, Seq Identity:31%, Plexin repeat

AA: 864-958, PDBID: 1HK6, Subunit A, Seq Identity:26%, IPT/TIG domain

AA: 961-1044, PDBID: 3MLP, Subunit E, Seq Identity:25%, IPT/TIG domain

AA: 1048-1146, PDBID: 1HK6, Subunit A, Seq Identity:18%, IPT/TIG domain

AA: 1150-1237, PDBID: 2UZY, Subunit B, Seq Identity:23%, IPT/TIG domain

AA: 1318-1866, PDBID: 3RYT, Subunit B, Seq Identity:98%, Plexin cytoplasmic RasGAP domain

UniProt annotation for PLXA1_HUMAN » Plexin-A1
FUNCTION: Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down- stream signaling events in the cytoplasm (By similarity).

SUBUNIT: Interacts directly with NRP1 and NRP2. Interacts with FARP2, RND1 and KDR/VEGFR2. Binding of SEMA3A leads to dissociation of FARP2 (By similarity).

TISSUE SPECIFICITY: Detected in fetal brain, lung, liver and kidney.

UniProt features for PLXA1_HUMAN » Plexin-A1
SIGNAL 1 26 Potential.
CHAIN 27 1896 Plexin-A1.
DOMAIN 27 512 Sema.
DOMAIN 864 959 IPT/TIG 1.
DOMAIN 961 1045 IPT/TIG 2.
DOMAIN 1048 1147 IPT/TIG 3.
DOMAIN 1150 1236 IPT/TIG 4.
COILED 1264 1317 Potential.
DISULFID 95 104 By similarity.
DISULFID 130 138 By similarity.
DISULFID 286 407 By similarity.
DISULFID 302 358 By similarity.
DISULFID 376 395 By similarity.
DISULFID 515 532 By similarity.
DISULFID 521 563 By similarity.
DISULFID 524 541 By similarity.
DISULFID 535 547 By similarity.
DISULFID 598 617 By similarity.
Amino Acid Sequence for PLXA1_HUMAN » Plexin-A1
MPLPPRSLQV LLLLLLLLLL LPGMWAEAGL PRAGGGSQPP FRTFSGSDWG LTHLLVHEQT GEVYVGAVNR IYKLSGNLTL LRAHVTGPVE DNEKCYPPPS VQSCPHGLGN TDNVNKLLLL DYAANRLLAC GSASQGICQS LRLDDLFKLG EPHHRKEHYL SSVQEAGSMA GVLIAGPPGQ GQAKLFVGTP IDGKSEYFPT LSSRRLMANE EDADMFGFVY QDEFVSSQLK IPSDTLSKFP AFDIYYVYSF RSEQFVYYLT LQLDTQLTSP DAAGEHFFTS KIVRLCVDDP KFYSYVEFPI GCEQAGVEYR LVQDAYLSRP GRALAHQLGL AEDEDVLFTV FAQGQKNRVK PPKESALCLF TLRAIKEKIK ERIQSCYRGE GKLSLPWLLN KELGCINSPL QIDDDFRGQD FNQPLGGTVT IEGTPLFVDK DDGLTAVAAY DYRGRTVVFA GTRSGRIRKI LVDLSNPGGR PALAYESVVA QEGSPILRDL VLSPNHQYLY AMTEKQVTRV PVESCVQYTS CELCLGSRDP HCGWCVLHSI CSRRDACERA DEPQRFAADL LQCVQLTVQP RNVSVTMSQV PLVLQAWNVP DLSAGVNCSF EDFTESESVL EDGRIHCRSP SAREVAPITR GQGDQRVVKL YLKSKETGKK FASVDFVFYN CSVHQSCLSC VNGSFPCHWC KYRHVCTHNV ADCAFLEGRV NVSEDCPQIL PSTQIYVPVG VVKPITLAAR NLPQPQSGQR GYECLFHIPG SPARVTALRF NSSSLQCQNS SYSYEGNDVS DLPVNLSVVW NGNFVIDNPQ NIQAHLYKCP ALRESCGLCL KADPRFECGW CVAERRCSLR HHCAADTPAS WMHARHGSSR CTDPKILKLS PETGPRQGGT RLTITGENLG LRFEDVRLGV RVGKVLCSPV ESEYISAEQI VCEIGDASSV RAHDALVEVC VRDCSPHYRA LSPKRFTFVT PTFYRVSPSR GPLSGGTWIG IEGSHLNAGS DVAVSVGGRP CSFSWRNSRE IRCLTPPGQS PGSAPIIINI NRAQLTNPEV KYNYTEDPTI LRIDPEWSIN SGGTLLTVTG TNLATVREPR IRAKYGGIER ENGCLVYNDT TMVCRAPSVA NPVRSPPELG ERPDELGFVM DNVRSLLVLN STSFLYYPDP VLEPLSPTGL LELKPSSPLI LKGRNLLPPA PGNSRLNYTV LIGSTPCTLT VSETQLLCEA PNLTGQHKVT VRAGGFEFSP GTLQVYSDSL LTLPAIVGIG GGGGLLLLVI VAVLIAYKRK SRDADRTLKR LQLQMDNLES RVALECKEAF AELQTDIHEL TNDLDGAGIP FLDYRTYAMR VLFPGIEDHP VLKEMEVQAN VEKSLTLFGQ LLTKKHFLLT FIRTLEAQRS FSMRDRGNVA SLIMTALQGE MEYATGVLKQ LLSDLIEKNL ESKNHPKLLL RRTESVAEKM LTNWFTFLLY KFLKECAGEP LFMLYCAIKQ QMEKGPIDAI TGEARYSLSE DKLIRQQIDY KTLTLNCVNP ENENAPEVPV KGLDCDTVTQ AKEKLLDAAY KGVPYSQRPK AADMDLEWRQ GRMARIILQD EDVTTKIDND WKRLNTLAHY QVTDGSSVAL VPKQTSAYNI SNSSTFTKSL SRYESMLRTA SSPDSLRSRT PMITPDLESG TKLWHLVKNH DHLDQREGDR GSKMVSEIYL TRLLATKGTL QKFVDDLFET IFSTAHRGSA LPLAIKYMFD FLDEQADKHQ IHDADVRHTW KSNCLPLRFW VNVIKNPQFV FDIHKNSITD ACLSVVAQTF MDSCSTSEHK LGKDSPSNKL LYAKDIPNYK SWVERYYADI AKMPAISDQD MSAYLAEQSR LHLSQFNSMS ALHEIYSYIT KYKDEILAAL EKDEQARRQR LRSKLEQVVD TMALSS