PLVAP_HUMAN » Plasmalemma vesicle-associated protein

PLVAP_HUMAN » Plasmalemma vesicle-associated protein
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PLVAP_HUMAN » Plasmalemma vesicle-associated protein » Fenestrated endothelial-linked structure protein;Plasmalemma vesicle protein 1;PV-1;
Hydrophobic Thickness 30.0 ± 2.0 Å
Tilt Angle 1 ± 0°
ΔGtransfer -38.1 kcal/mol
ΔGfold -20.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 25-49 (22-49)
Pathways none
PDB none
OPM none
Complexes none
Interactions

NRP1, Complex: PLVAP:NRP1

Domains

AA: 1-440, PV-1 protein (PLVAP)

UniProt annotation for PLVAP_HUMAN » Plasmalemma vesicle-associated protein
FUNCTION: Involved in the formation of stomatal and fenestral diaphragms of caveolae. May function in microvascular permeability.

SUBUNIT: Homodimer.

TISSUE SPECIFICITY: Expressed in lung, kidney, heart, aorta, placenta, muscle, pituitary gland, adrenals, mammary gland, bladder, lymph node, bone marrow, trachea, digestive tract, liver and tumor-associated endothelium.

INDUCTION: By phorbol myristate acetate (PMA) or VEGF in endothelial cell culture.

UniProt features for PLVAP_HUMAN » Plasmalemma vesicle-associated protein
CHAIN 1 442 Plasmalemma vesicle-associated protein.
COILED 57 77 Potential.
COILED 202 225 Potential.
COILED 280 387 Potential.
Amino Acid Sequence for PLVAP_HUMAN » Plasmalemma vesicle-associated protein
MGLAMEHGGS YARAGGSSRG CWYYLRYFFL FVSLIQFLII LGLVLFMVYG NVHVSTESNL QATERRAEGL YSQLLGLTAS QSNLTKELNF TTRAKDAIMQ MWLNARRDLD RINASFRQCQ GDRVIYTNNQ RYMAAIILSE KQCRDQFKDM NKSCDALLFM LNQKVKTLEV EIAKEKTICT KDKESVLLNK RVAEEQLVEC VKTRELQHQE RQLAKEQLQK VQALCLPLDK DKFEMDLRNL WRDSIIPRSL DNLGYNLYHP LGSELASIRR ACDHMPSLMS SKVEELARSL RADIERVARE NSDLQRQKLE AQQGLRASQE AKQKVEKEAQ AREAKLQAEC SRQTQLALEE KAVLRKERDN LAKELEEKKR EAEQLRMELA IRNSALDTCI KTKSQPMMPV SRPMGPVPNP QPIDPASLEE FKRKILESQR PPAGIPVAPS SG