PLDX1_HUMAN » Plexin domain-containing protein 1

PLDX1_HUMAN » Plexin domain-containing protein 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PLDX1_HUMAN » Plexin domain-containing protein 1 » Tumor endothelial marker 3;Tumor endothelial marker 7;
Hydrophobic Thickness 33.2 ± 2.8 Å
Tilt Angle 0 ± 1°
ΔGtransfer -50.5 kcal/mol
ΔGfold -21.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 424-448 (421-450)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 303-348, PDBID: 3NVN, Subunit B, Seq Identity:32%, Plexin repeat

UniProt annotation for PLDX1_HUMAN » Plexin domain-containing protein 1
FUNCTION: Plays a critical role in endothelial cell capillary morphogenesis.

SUBUNIT: Interacts with NID1. May interact with CTTN.

TISSUE SPECIFICITY: Detected in endothelial cells from colorectal cancer, and in endothelial cells from primary cancers of the lung, liver, pancreas, breast and brain. Not detectable in endothelial cells from normal tissue. Expressed in fibrovascular membrane with increased expression in individuals with proliferative diabetic retinopathy.

UniProt features for PLDX1_HUMAN » Plexin domain-containing protein 1
SIGNAL 1 18 Potential.
CHAIN 19 500 Plexin domain-containing protein 1.
Amino Acid Sequence for PLDX1_HUMAN » Plexin domain-containing protein 1
MRGELWLLVL VLREAARALS PQPGAGHDEG PGSGWAAKGT VRGWNRRARE SPGHVSEPDR TQLSQDLGGG TLAMDTLPDN RTRVVEDNHS YYVSRLYGPS EPHSRELWVD VAEANRSQVK IHTILSNTHR QASRVVLSFD FPFYGHPLRQ ITIATGGFIF MGDVIHRMLT ATQYVAPLMA NFNPGYSDNS TVVYFDNGTV FVVQWDHVYL QGWEDKGSFT FQAALHHDGR IVFAYKEIPM SVPEISSSQH PVKTGLSDAF MILNPSPDVP ESRRRSIFEY HRIELDPSKV TSMSAVEFTP LPTCLQHRSC DACMSSDLTF NCSWCHVLQR CSSGFDRYRQ EWMDYGCAQE AEGRMCEDFQ DEDHDSASPD TSFSPYDGDL TTTSSSLFID SLTTEDDTKL NPYAGGDGLQ NNLSPKTKGT PVHLGTIVGI VLAVLLVAAI ILAGIYINGH PTSNAALFFI ERRPHHWPAM KFRSHPDHST YAEVEPSGHE KEGFMEAEQC