PLA2R_HUMAN » Secretory phospholipase A2 receptor

PLA2R_HUMAN » Secretory phospholipase A2 receptor
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PLA2R_HUMAN » Secretory phospholipase A2 receptor » PLA2-R; PLA2R; 180 kDa secretory phospholipase A2 receptor;C-type lectin domain family 13 member C;M-type receptor;
Hydrophobic Thickness 34.6 ± 1.2 Å
Tilt Angle 22 ± 0°
ΔGtransfer -25.6 kcal/mol
ΔGfold -19.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 1398-1420 (1398-1424)
Pathways

Phagosome (KEGG)

Tuberculosis (KEGG)

PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 178-219, PDBID: 5AO5, Subunit B, Seq Identity:62%, Fibronectin type II domain

AA: 249-356, PDBID: 5AO5, Subunit A, Seq Identity:47%, Lectin C-type domain

AA: 395-503, PDBID: 5AO5, Subunit A, Seq Identity:39%, Lectin C-type domain

AA: 547-645, PDBID: 1T8C, Subunit A, Seq Identity:23%, Lectin C-type domain

AA: 688-798, PDBID: 5AO5, Subunit A, Seq Identity:28%, Lectin C-type domain

AA: 830-939, PDBID: 5AO5, Subunit A, Seq Identity:33%, Lectin C-type domain

AA: 980-1098, PDBID: 1T8C, Subunit A, Seq Identity:30%, Lectin C-type domain

AA: 1131-1234, PDBID: 1T8C, Subunit A, Seq Identity:35%, Lectin C-type domain

AA: 1269-1379, PDBID: 1GZ2, Subunit A, Seq Identity:28%, Lectin C-type domain

UniProt annotation for PLA2R_HUMAN » Secretory phospholipase A2 receptor
FUNCTION: Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2- IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2- IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow- derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in proinflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B.

TISSUE SPECIFICITY: Present in lung macrophage (at protein level). Highly expressed in kidney. Also expressed in pancreas, amnion, choriodecidua and placenta. Isoform 2 is expressed at much lower level.

DOMAIN: C-type lectin domains 3-5 mediate the interaction with phospholipase PLA2G1B.

DOMAIN: The endocytosis signal probably mediates endocytosis via clathrin-coated pits.

UniProt features for PLA2R_HUMAN » Secretory phospholipase A2 receptor
SIGNAL 1 20 By similarity.
CHAIN 21 1463 Secretory phospholipase A2 receptor.
CHAIN 21 ? Soluble secretory phospholipase A2 receptor (By similarity).
DOMAIN 38 161 Ricin B-type lectin.
DOMAIN 173 221 Fibronectin type-II.
DOMAIN 238 355 C-type lectin 1.
DOMAIN 385 502 C-type lectin 2.
DOMAIN 522 643 C-type lectin 3.
DOMAIN 673 797 C-type lectin 4.
DOMAIN 819 938 C-type lectin 5.
DOMAIN 965 1096 C-type lectin 6.
DOMAIN 1121 1232 C-type lectin 7.
DOMAIN 1257 1378 C-type lectin 8.
MOTIF 1436 1442 Endocytosis signal.
DISULFID 51 64 By similarity.
DISULFID 89 106 By similarity.
DISULFID 178 204 By similarity.
DISULFID 192 219 By similarity.
DISULFID 260 354 By similarity.
DISULFID 330 346 By similarity.
DISULFID 406 501 By similarity.
DISULFID 478 493 By similarity.
DISULFID 617 634 By similarity.
DISULFID 699 796 By similarity.
DISULFID 774 788 By similarity.
DISULFID 840 937 By similarity.
DISULFID 914 929 By similarity.
DISULFID 1067 1087 By similarity.
DISULFID 1209 1223 By similarity.
DISULFID 1280 1377 By similarity.
DISULFID 1354 1369 By similarity.
Amino Acid Sequence for PLA2R_HUMAN » Secretory phospholipase A2 receptor
MLLSPSLLLL LLLGAPRGCA EGVAAALTPE RLLEWQDKGI FVIQSESLKK CIQAGKSVLT LENCKQANKH MLWKWVSNHG LFNIGGSGCL GLNFSAPEQP LSLYECDSTL VSLRWRCNRK MITGPLQYSV QVAHDNTVVA SRKYIHKWIS YGSGGGDICE YLHKDLHTIK GNTHGMPCMF PFQYNHQWHH ECTREGREDD LLWCATTSRY ERDEKWGFCP DPTSAEVGCD TIWEKDLNSH ICYQFNLLSS LSWSEAHSSC QMQGGTLLSI TDETEENFIR EHMSSKTVEV WMGLNQLDEH AGWQWSDGTP LNYLNWSPEV NFEPFVEDHC GTFSSFMPSA WRSRDCESTL PYICKKYLNH IDHEIVEKDA WKYYATHCEP GWNPYNRNCY KLQKEEKTWH EALRSCQADN SALIDITSLA EVEFLVTLLG DENASETWIG LSSNKIPVSF EWSNDSSVIF TNWHTLEPHI FPNRSQLCVS AEQSEGHWKV KNCEERLFYI CKKAGHVLSD AESGCQEGWE RHGGFCYKID TVLRSFDQAS SGYYCPPALV TITNRFEQAF ITSLISSVVK MKDSYFWIAL QDQNDTGEYT WKPVGQKPEP VQYTHWNTHQ PRYSGGCVAM RGRHPLGRWE VKHCRHFKAM SLCKQPVENQ EKAEYEERWP FHPCYLDWES EPGLASCFKV FHSEKVLMKR TWREAEAFCE EFGAHLASFA HIEEENFVNE LLHSKFNWTE ERQFWIGFNK RNPLNAGSWE WSDRTPVVSS FLDNTYFGED ARNCAVYKAN KTLLPLHCGS KREWICKIPR DVKPKIPFWY QYDVPWLFYQ DAEYLFHTFA SEWLNFEFVC SWLHSDLLTI HSAHEQEFIH SKIKALSKYG ASWWIGLQEE RANDEFRWRD GTPVIYQNWD TGRERTVNNQ SQRCGFISSI TGLWGSEECS VSMPSICKRK KVWLIEKKKD TPKQHGTCPK GWLYFNYKCL LLNIPKDPSS WKNWTHAQHF CAEEGGTLVA IESEVEQAFI TMNLFGQTTS VWIGLQNDDY ETWLNGKPVV YSNWSPFDII NIPSHNTTEV QKHIPLCALL SSNPNFHFTG KWYFEDCGKE GYGFVCEKMQ DTSGHGVNTS DMYPMPNTLE YGNRTYKIIN ANMTWYAAIK TCLMHKAQLV SITDQYHQSF LTVVLNRLGY AHWIGLFTTD NGLNFDWSDG TKSSFTFWKD EESSLLGDCV FADSNGRWHS TACESFLQGA ICHVPPETRQ SEHPELCSET SIPWIKFKSN CYSFSTVLDS MSFEAAHEFC KKEGSNLLTI KDEAENAFLL EELFAFGSSV QMVWLNAQFD GNNETIKWFD GTPTDQSNWG IRKPDTDYFK PHHCVALRIP EGLWQLSPCQ EKKGFICKME ADIHTAEALP EKGPSHSIIP LAVVLTLIVI VAICTLSFCI YKHNGGFFRR LAGFRNPYYP ATNFSTVYLE ENILISDLEK SDQ