PKHL1_HUMAN » Fibrocystin-L

PKHL1_HUMAN » Fibrocystin-L
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PKHL1_HUMAN » Fibrocystin-L » Polycystic kidney and hepatic disease 1-like protein 1;PKHD1-like protein 1;
Hydrophobic Thickness 32.2 ± 3.9 Å
Tilt Angle 11 ± 9°
ΔGtransfer -13.4 kcal/mol
ΔGfold -7.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 4206-4228 (4202-4232)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 31-132, PDBID: 2UZY, Subunit B, Seq Identity:25%, IPT/TIG domain

AA: 146-255, PDBID: 2UZX, Subunit B, Seq Identity:22%, IPT/TIG domain

AA: 270-356, PDBID: 2UZY, Subunit B, Seq Identity:30%, IPT/TIG domain

AA: 340-490, PDBID: 2XJP, Subunit A, Seq Identity:18%, PA14 domain

AA: 1067-1151, PDBID: 2UZY, Subunit B, Seq Identity:33%, IPT/TIG domain

AA: 1155-1235, PDBID: 3KYA, Subunit A, Seq Identity:27%, IPT/TIG domain

AA: 1240-1325, PDBID: 2UZY, Subunit B, Seq Identity:31%, IPT/TIG domain

AA: 1330-1403, PDBID: 2UZY, Subunit B, Seq Identity:27%, IPT/TIG domain

AA: 1566-1650, PDBID: 2UZY, Subunit B, Seq Identity:28%, IPT/TIG domain

AA: 1659-1743, PDBID: 3MLP, Subunit E, Seq Identity:28%, IPT/TIG domain

AA: 1749-1830, PDBID: 1UAD, Subunit D, Seq Identity:28%, IPT/TIG domain

AA: 1831-1910, PDBID: 2CXK, Subunit A, Seq Identity:31%, IPT/TIG domain

AA: 1916-1997, PDBID: 1HK6, Subunit A, Seq Identity:30%, IPT/TIG domain

AA: 1999-2085, PDBID: 3KYA, Subunit A, Seq Identity:20%, IPT/TIG domain

AA: 2091-2176, PDBID: 2UZY, Subunit B, Seq Identity:28%, IPT/TIG domain

AA: 2185-2303, G8 domain

AA: 3037-3173, G8 domain

UniProt annotation for PKHL1_HUMAN » Fibrocystin-L
TISSUE SPECIFICITY: Ubiquitous. Expressed in spleen and thymus as well as in activated T-cells and B-lymphoblasts.
UniProt features for PKHL1_HUMAN » Fibrocystin-L
SIGNAL 1 20 Potential.
CHAIN 21 4243 Fibrocystin-L.
DOMAIN 31 129 IPT/TIG 1.
DOMAIN 146 255 IPT/TIG 2.
DOMAIN 270 361 IPT/TIG 3.
DOMAIN 1067 1151 IPT/TIG 4.
DOMAIN 1155 1234 IPT/TIG 5.
DOMAIN 1240 1322 IPT/TIG 6.
DOMAIN 1330 1469 IPT/TIG 7.
DOMAIN 1566 1649 IPT/TIG 8.
DOMAIN 1659 1743 IPT/TIG 9.
DOMAIN 1749 1828 IPT/TIG 10.
DOMAIN 1831 1910 IPT/TIG 11.
DOMAIN 1916 1997 IPT/TIG 12.
DOMAIN 1999 2085 IPT/TIG 13.
DOMAIN 2091 2176 IPT/TIG 14.
DOMAIN 2184 2304 G8 1.
REPEAT 2508 2530 PbH1 1.
REPEAT 2566 2588 PbH1 2.
REPEAT 2665 2687 PbH1 3.
REPEAT 2733 2756 PbH1 4.
DOMAIN 3036 3174 G8 2.
REPEAT 3293 3315 PbH1 5.
REPEAT 3355 3377 PbH1 6.
REPEAT 3416 3438 PbH1 7.
REPEAT 3471 3493 PbH1 8.
REPEAT 3527 3548 PbH1 9.
Amino Acid Sequence for PKHL1_HUMAN » Fibrocystin-L
MGHLWLLGIW GLCGLLLCAA DPSTDGSQII PKVTEIIPKY GSINGATRLT IRGEGFSQAN QFNYGVDNAE LGNSVQLISS FQSITCDVEK DASHSTQITC YTRAMPEDSY TVRVSVDGVP VTENNTCKGH INSWECTFNA KSFRTPTIRS ITPLSGTPGT LITIQGRIFT DVYGSNIALS SNGKNVRILR VYIGGMPCEL LIPQSDNLYG LKLDHPNGDM GSMVCKTTGT FIGHHNVSFI LDNDYGRSFP QKMAYFVSSL NKIAMFQTYA EVTMIFPSQG SIRGGTTLTI SGRFFDQTDF PVRVLVGGEP CDILNVTENS ICCKTPPKPH ILKTVYPGGR GLKLEVWNNS RPIRLEEILE YNEKTPGYMG ASWVDSASYI WLMEQDTFVA RFSGFLVAPD SDVYRFYIKG DDRYAIYFSQ TGLPEDKVRI AYHSANANSY FSSPTQRSDD IHLQKGKEYY IEILLQEYRL SAFVDVGLYQ YRNVYTEQQT GDAVNEEQVI KSQSTILQEV QVITLENWET TNAINEVQKI KVTSPCVEAN SCSLYQYRLI YNMEKTVFLP ADASEFILQS ALNDLWSIKP DTVQVIRTQN PQSYVYMVTF ISTRGDFDLL GYEVVEGNNV TLDITEQTKG KPNLETFTLN WDGIASKPLT LWSSEAEFQG AVEEMVSTKC PPQIANFEEG FVVKYFRDYE TDFNLEHINR GQKTAETDAY CGRYSLKNPA VLFDSADVKP NRRPYGDILL FPYNQLCLAY KGFLANYIGL KFQYQDNSKI TRSTDTQFTY NFAYGNNWTY TCIDLLDLVR TKYTGTNVSL QRISLHKASE SQSFYVDVVY IGHTSTISTL DEMPKRRLPA LANKGIFLEH FQVNQTKTNG PTMTNQYSVT MTSYNCSYNI PMMAVSFGQI ITHETENEFV YRGNNWPGES KIHIQRIQAA SPPLSGSFDI QAYGHILKGL PAAVSAADLQ FALQSLEGMG RISVTREGTC AGYAWNIKWR STCGKQNLLQ INDSNIIGEK ANMTVTRIKE GGLFRQHVLG DLLRTPSQQP QVEVYVNGIP AKCSGDCGFT WDSNITPLVL AISPSQGSYE EGTILTIVGS GFSPSSAVTV SVGPVGCSLL SVDEKELKCQ ILNGSAGHAP VAVSMADVGL AQNVGGEEFY FVYQSQISHI WPDSGSIAGG TLLTLSGFGF NENSKVLVGN ETCNVIEGDL NRITCRTPKK TEGTVDISVT TNGFQATARD AFSYNCLQTP IITDFSPKVR TILGEVNLTI KGYNFGNELT QNMAVYVGGK TCQILHWNFT DIRCLLPKLS PGKHDIYVEV RNWGFASTRD KLNSSIQYVL EVTSMFPQRG SLFGGTEITI RGFGFSTIPA ENTVLLGSIP CNVTSSSENV IKCILHSTGN IFRITNNGKD SVHGLGYAWS PPVLNVSVGD TVAWHWQTHP FLRGIGYRIF SVSSPGSVIY DGKGFTSGRQ KSTSGSFSYQ FTSPGIHYYS SGYVDEAHSI FLQGVINVLP AETRHIPLHL FVGRSEATYA YGGPENLHLG SSVAGCLATE PLCSLNNTRV KNSKRLLFEV SSCFSPSISN ITPSTGTVNE LITIIGHGFS NLPWANKVTI GSYPCVVEES SEDSITCHID PQNSMDVGIR ETVTLTVYNL GTAINTLSNE FDRRFVLLPN IDLVLPNAGS TTGMTSVTIK GSGFAVSSAG VKVLMGHFPC KVLSVNYTAI ECETSPAAQQ LVDVDLLIHG VPAQCQGNCT FSYLESITPY ITGVFPNSVI GSVKVLIEGE GLGTVLEDIA VFIGNQQFRA IEVNENNITA LVTPLPVGHH SVSVVVGSKG LALGNLTVSS PPVASLSPTS GSIGGGTTLV ITGNGFYPGN TTVTIGDEPC QIISINPNEV YCRTPAGTTG MVDVKIFVNT IAYPPLLFTY ALEDTPFLRG IIPSRGPPGT EIEITGSNFG FEILEISVMI NNIQCNVTMA NDSVLQCIVG DHAGGTFPVM MHHKTKGSAM STVVFEYPLN IQNINPSQGS FGGGQTMTVT GTGFNPQNSI ILVCGSECAI DRLRSDYTTL LCEIPSNNGT GAEQACEVSV VNGKDLSQSM TPFTYAVSLT PLITAVSPKR GSTAGGTRLT VVGSGFSENM EDVHITIAEA KCDVEYSNKT HIICMTDAHT LSGWAPVCVH IRGVGMAKLD NADFLYVDAW SSNFSWGGKS PPEEGSLVVI TKGQTILLDQ STPILKMLLI QGGTLIFDEA DIELQAENIL ITDGGVLQIG TETSPFQHKA VITLHGHLRS PELPVYGAKT LAVREGILDL HGVPVPVTWT RLAHTAKAGE RILILQEAVT WKPGDNIVIA STGHRHSQGE NEKMTIASVS ADGINITLSN PLNYTHLGIT VTLPDGTLFE ARAEVGILTR NILIRGSDNV EWNNKIPACP DGFDTGEFAT QTCLQGKFGE EIGSDQFGGC VMFHAPVPGA NMVTGRIEYV EVFHAGQAFR LGRYPIHWHL LGDLQFKSYV RGCAIHQAYN RAVTIHNTHH LLVERNIIYD IKGGAFFIED GIEHGNILQY NLAVFVQQST SLLNDDVTPA AFWVTNPNNT IRHNAVAGGT HFGFWYRMNN HPDGPSYDRN ICQKRVPLGE FFNNTVHSQG WFGMWIFEEY FPMQTGSCTS TVPAPAIFNS LTTWNCQKGA EWVNGGALQF HNFVMVNNYE AGIETKRILA PYVGGWGETN GAVIKNAKIV GHLDELGMGS AFCTAKGLVL PFSEGLTVSS VHFMNFDRPN CVALGVTSIS GVCNDRCGGW SAKFVDVQYS HTPNKAGFRW EHEMVMIDVD GSLTGHKGHT VIPHSSLLDP SHCTQEAEWS IGFPGSVCDA SVSFHRLAFN QPSPVSLLEK DVVLSDSFGT SIIPFQKKRL THMSGWMALI PNANHINWYF KGVDHITNIS YTSTFYGFKE EDYVIISHNF TQNPDMFNII DMRNGSSNPL NWNTSKNGDW HLEANTSTLY YLVSGRNDLH QSQLISGNLD PDVKDVVINF QAYCCILQDC FPVHPPSRKP IPKKRPATYN LWSNDSFWQS SRENNYTVPH PGANVIIPEG TWIVADIDMP SMERLIIWGV LELEDKYNVG AAESSYREVV LNATYISLQG GRLIGGWEDN PFKGDLKIVL RGNHTTQDWA LPEGPNQGAK VLGVFGELDL HGIPHSIYKT KLSETAFAGS KVLSLMDAVD WQEGEEIVIT TTSYDFHQTE TRSIVKILHD HKILILNDSL SYTHFAEKYH VPGTGESYTL AADVGILSRN IKIVGEDYPG WSEDSFGARV LVGSFTENMM TFKGNARISN VEFYHSGQEG FRDSTDPRYA VTFLNLGQIQ EHGSSYIRGC AFHHGFSPAI GVFGTDGLDI DDNIIHFTVG EGIRIWGNAN RVRGNLIALS VWPGTYQNRK DLSSTLWHAA IEINRGTNTV LQNNVVAGFG RAGYRIDGEP CPGQFNPVEK WFDNEAHGGL YGIYMNQDGL PGCSLIQGFT IWTCWDYGIY FQTTESVHIY NVTLVDNGMA IFPMIYMPAA ISHKISSKNV QIKSSLIVGS SPGFNCSDVL TNDDPNIELT AAHRSPRSPS GGRSGICWPT FASAHNMAPR KPHAGIMSYN AISGLLDISG STFVGFKNVC SGETNVIFIT NPLNEDLQHP IHVKNIKLVD TTEQSKIFIH RPDISKVNPS DCVDMVCDAK RKSFLRDIDG SFLGNAGSVI PQAEYEWDGN SQVGIGDYRI PKAMLTFLNG SRIPVTEKAP HKGIIRDSTC KYLPEWQSYQ CFGMEYAMMV IESLDPDTET RRLSPVAIMG NGYVDLINGP QDHGWCAGYT CQRRLSLFHS IVALNKSYEV YFTGTSPQNL RLMLLNVDHN KAVLVGIFFS TLQRLDVYVN NLLVCPKTTI WNAQQKHCEL NNHLYKDQFL PNLDSTVLGE NYFDGTYQML YLLVKGTIPV EIHTATVIFV SFQLSVATED DFYTSHNLVK NLALFLKIPS DKIRISKIRG KSLRRKRSMG FIIEIEIGDP PIQFISNGTT GQMQLSELQE IAGSLGQAVI LGNISSILGF NISSMSITNP LPSPSDSGWI KVTAQPVERS AFPVHHVAFV SSLLVITQPV AAQPGQPFPQ QPSVKATDSD GNCVSVGITA LTLRAILKDS NNNQVNGLSG NTTIPFSSCW ANYTDLTPLR TGKNYKIEFI LDNVVGVESR TFSLLAESVS SSGSSSSSNS KASTVGTYAQ IMTVVISCLV GRMWLLEIFM AAVSTLNITL RSY