PILRB_HUMAN » Paired immunoglobulin-like type 2 receptor beta

PILRB_HUMAN » Paired immunoglobulin-like type 2 receptor beta
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PILRB_HUMAN » Paired immunoglobulin-like type 2 receptor beta » Activating receptor PILR-beta;Cell surface receptor FDFACT;
Hydrophobic Thickness 34.6 ± 1.0 Å
Tilt Angle 1 ± 0°
ΔGtransfer -24.3 kcal/mol
ΔGfold -20.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 193-215 (186-218)
Pathways none
PDB 4nfc (32-150), 4nfd (32-150)
OPM none
Complexes none
Interactions none
Domains

AA: 36-150, PDBID: 4NFC, Subunit A, Seq Identity:100%, Immunoglobulin V-set domain

UniProt annotation for PILRB_HUMAN » Paired immunoglobulin-like type 2 receptor beta
FUNCTION: Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB is thought to act as a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface.
UniProt features for PILRB_HUMAN » Paired immunoglobulin-like type 2 receptor beta
SIGNAL 1 19 Potential.
CHAIN 20 227 Paired immunoglobulin-like type 2 receptor beta.
DOMAIN 21 143 Ig-like V-type.
Amino Acid Sequence for PILRB_HUMAN » Paired immunoglobulin-like type 2 receptor beta
MGRPLLLPLL LLLQPPAFLQ PGGSTGSGPS YLYGVTQPKH LSASMGGSVE IPFSFYYPWE LAIVPNVRIS WRRGHFHGQS FYSTRPPSIH KDYVNRLFLN WTEGQESGFL RISNLRKEDQ SVYFCRVELD TRRSGRQQLQ SIKGTKLTIT QAVTTTTTWR PSSTTTIAGL RVTESKGHSE SWHLSLDTAI RVALAVAVLK TVILGLLCLL LLWWRRRKGS RAPSSDF