PILRA_HUMAN » Paired immunoglobulin-like type 2 receptor alpha

PILRA_HUMAN » Paired immunoglobulin-like type 2 receptor alpha
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PILRA_HUMAN » Paired immunoglobulin-like type 2 receptor alpha » Cell surface receptor FDF03;Inhibitory receptor PILR-alpha;
Hydrophobic Thickness 33.2 ± 3.0 Å
Tilt Angle 0 ± 0°
ΔGtransfer -43.2 kcal/mol
ΔGfold -21.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 194-221 (193-224)
Pathways

Herpes simplex infection (KEGG)

PDB 3wuz (32-150), 4nfb (32-150), 3wv0 (A/B=32-150)
OPM none
Complexes none
Interactions

FCAR, Complex: FCAR:PILRA, PubMed

Domains

AA: 36-150, PDBID: 3WUZ, Subunit A, Seq Identity:100%, Immunoglobulin V-set domain

UniProt annotation for PILRA_HUMAN » Paired immunoglobulin-like type 2 receptor alpha
FUNCTION: Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRA is thought to act as a cellular signaling inhibitory receptor by recruiting cytoplasmic phosphatases like PTPN6/SHP-1 and PTPN11/SHP-2 via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. Receptor for PIANP.

SUBUNIT: Monomer. Interacts with PTPN6/SHP-1 and PTPN11/SHP-2 upon tyrosine phosphorylation. Interacts with herpes simplex virus 1 glycoprotein B; functions as an entry coreceptor for this virus.

TISSUE SPECIFICITY: Predominantly detected in hemopoietic tissues and is expressed by monocytes, macrophages, and granulocytes, but not by lymphocytes. Also strongly expressed by dendritic cells (DC); preferentially by CD14+/CD1a- DC derived from CD34+ progenitors. Also expressed by CD11c+ blood and tonsil DC, but not by CD11c- DC precursors.

DOMAIN: Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2- containing phosphatases. PTPN6 seems to bind predominantly to the first ITIM motif.

UniProt features for PILRA_HUMAN » Paired immunoglobulin-like type 2 receptor alpha
SIGNAL 1 19 Potential.
CHAIN 20 303 Paired immunoglobulin-like type 2 receptor alpha.
DOMAIN 32 150 Ig-like V-type.
MOTIF 267 272 ITIM motif 1.
MOTIF 296 301 ITIM motif 2.
Amino Acid Sequence for PILRA_HUMAN » Paired immunoglobulin-like type 2 receptor alpha
MGRPLLLPLL PLLLPPAFLQ PSGSTGSGPS YLYGVTQPKH LSASMGGSVE IPFSFYYPWE LATAPDVRIS WRRGHFHGQS FYSTRPPSIH KDYVNRLFLN WTEGQKSGFL RISNLQKQDQ SVYFCRVELD TRSSGRQQWQ SIEGTKLSIT QAVTTTTQRP SSMTTTWRLS STTTTTGLRV TQGKRRSDSW HISLETAVGV AVAVTVLGIM ILGLICLLRW RRRKGQQRTK ATTPAREPFQ NTEEPYENIR NEGQNTDPKL NPKDDGIVYA SLALSSSTSP RAPPSHRPLK SPQNETLYSV LKA