PIGR_HUMAN » Polymeric immunoglobulin receptor

PIGR_HUMAN » Polymeric immunoglobulin receptor
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PIGR_HUMAN » Polymeric immunoglobulin receptor » PIgR; Poly-Ig receptor; Hepatocellular carcinoma-associated protein TB6;
Hydrophobic Thickness 30.8 ± 2.0 Å
Tilt Angle 2 ± 1°
ΔGtransfer -32.5 kcal/mol
ΔGfold -13.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 639-663 (635-666)
Pathways

Intestinal immune network for IgA production (KEGG)

PDB 2ocw (19-603), 1xed (A/B...=19-127), 3chn (J=353-458,S=19-603), 3cm9 (J=353-458,S=19-603)
OPM none
Complexes none
Interactions

CD79A, Complex: PIGR:CD79A, PubMed

Domains

AA: 23-128, PDBID: 1XED, Subunit C, Seq Identity:100%, Immunoglobulin V-set domain

AA: 136-238, PDBID: 4NOF, Subunit B, Seq Identity:52%, Immunoglobulin V-set domain

AA: 241-341, PDBID: 4NOF, Subunit B, Seq Identity:29%, Immunoglobulin V-set domain

AA: 354-457, PDBID: 1XED, Subunit C, Seq Identity:38%, Immunoglobulin V-set domain

AA: 465-562, PDBID: 1ZOX, Subunit A, Seq Identity:32%, Immunoglobulin V-set domain

UniProt annotation for PIGR_HUMAN » Polymeric immunoglobulin receptor
FUNCTION: This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.
UniProt features for PIGR_HUMAN » Polymeric immunoglobulin receptor
SIGNAL 1 18
CHAIN 19 764 Polymeric immunoglobulin receptor.
CHAIN 19 603 Secretory component.
DOMAIN 19 120 Ig-like V-type 1.
DOMAIN 145 237 Ig-like V-type 2.
DOMAIN 250 352 Ig-like V-type 3.
DOMAIN 364 458 Ig-like V-type 4.
DOMAIN 462 561 Ig-like V-type 5.
DISULFID 40 110
DISULFID 56 64
DISULFID 152 220
DISULFID 257 325
DISULFID 271 279
DISULFID 371 441
DISULFID 385 395
DISULFID 482 544
DISULFID 486 520
DISULFID 496 503
Amino Acid Sequence for PIGR_HUMAN » Polymeric immunoglobulin receptor
MLLFVLTCLL AVFPAISTKS PIFGPEEVNS VEGNSVSITC YYPPTSVNRH TRKYWCRQGA RGGCITLISS EGYVSSKYAG RANLTNFPEN GTFVVNIAQL SQDDSGRYKC GLGINSRGLS FDVSLEVSQG PGLLNDTKVY TVDLGRTVTI NCPFKTENAQ KRKSLYKQIG LYPVLVIDSS GYVNPNYTGR IRLDIQGTGQ LLFSVVINQL RLSDAGQYLC QAGDDSNSNK KNADLQVLKP EPELVYEDLR GSVTFHCALG PEVANVAKFL CRQSSGENCD VVVNTLGKRA PAFEGRILLN PQDKDGSFSV VITGLRKEDA GRYLCGAHSD GQLQEGSPIQ AWQLFVNEES TIPRSPTVVK GVAGGSVAVL CPYNRKESKS IKYWCLWEGA QNGRCPLLVD SEGWVKAQYE GRLSLLEEPG NGTFTVILNQ LTSRDAGFYW CLTNGDTLWR TTVEIKIIEG EPNLKVPGNV TAVLGETLKV PCHFPCKFSS YEKYWCKWNN TGCQALPSQD EGPSKAFVNC DENSRLVSLT LNLVTRADEG WYWCGVKQGH FYGETAAVYV AVEERKAAGS RDVSLAKADA APDEKVLDSG FREIENKAIQ DPRLFAEEKA VADTRDQADG SRASVDSGSS EEQGGSSRAL VSTLVPLGLV LAVGAVAVGV ARARHRKNVD RVSIRSYRTD ISMSDFENSR EFGANDNMGA SSITQETSLG GKEEFVATTE STTETKEPKK AKRSSKEEAE MAYKDFLLQS STVAAEAQDG PQEA