PIANP_HUMAN » PILR alpha-associated neural protein

PIANP_HUMAN » PILR alpha-associated neural protein
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PIANP_HUMAN » PILR alpha-associated neural protein » PILR-associating neural protein;Paired immunoglobin-like type 2 receptor-associating neural protein;
Hydrophobic Thickness 34.8 ± 3.8 Å
Tilt Angle 20 ± 15°
ΔGtransfer -26.6 kcal/mol
ΔGfold -19.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 179-203 (178-207)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 160-244, AJAP1/PANP C-terminus

UniProt annotation for PIANP_HUMAN » PILR alpha-associated neural protein
FUNCTION: Acts as a ligand for PILRA in neural tissues, where it may be involved in immune regulation.

TISSUE SPECIFICITY: Mainly expressed in adult brain and cerebellum. Weaker expression in fetal brain and virtually no expression in spleen, heart, kidney, liver and dorsal ganglion relative to brain.

UniProt features for PIANP_HUMAN » PILR alpha-associated neural protein
SIGNAL 1 31 Potential.
CHAIN 32 282 PILR alpha-associated neural protein.
Amino Acid Sequence for PIANP_HUMAN » PILR alpha-associated neural protein
MESRMWPALL LSHLLPLWPL LLLPLPPPAQ GSSSSPRTPP APARPPCARG GPSAPRHVCV WERAPPPSRS PRVPRSRRQV LPGTAPPATP SGFEEGPPSS QYPWAIVWGP TVSREDGGDP NSANPGFLDY GFAAPHGLAT PHPNSDSMRG DGDGLILGEA PATLRPFLFG GRGEGVDPQL YVTITISIII VLVATGIIFK FCWDRSQKRR RPSGQQGALR QEESQQPLTD LSPAGVTVLG AFGDSPTPTP DHEEPRGGPR PGMPHPKGAP AFQLNRIPLV NL