PHB4_ARATH » Prohibitin-4, mitochondrial

PHB4_ARATH » Prohibitin-4, mitochondrial
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Topology in Mitochondrial inner membrane
Topologyintermembrane space
mitochondrial matrix side
PHB4_ARATH » Prohibitin-4, mitochondrial » Atphb4;
Hydrophobic Thickness 29.0 ± 2.1 Å
Tilt Angle 32 ± 1°
ΔGtransfer -14.4 kcal/mol
ΔGfold -6.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology In
TM Segments 6-28 (3-32)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 33-223, PDBID: 4FVF, Subunit A, Seq Identity:20%, SPFH domain / Band 7 family

UniProt annotation for PHB4_ARATH » Prohibitin-4, mitochondrial
FUNCTION: Prohibitin probably acts as a holdase/unfoldase for the stabilization of newly synthesized mitochondrial proteins.

SUBUNIT: Component of a prohibitin multimeric complex in mitochondrial membranes.

TISSUE SPECIFICITY: Mostly expressed in proliferative tissues, including vasculature, shoot and root apical tissues. Accumulates in dry seeds.

DEVELOPMENTAL STAGE: Observed in all organs primordia and meristems. In cotyledons, hypocotyls and differentiating leaves, present in stomatal meristemoid cells, guard mother cells and trichomes. Within the anthers, transiently expressed in the proximity of the sporogenous tissue. Accumulates in embryos at globular stages, except in suspensor cell. In root elongation zones, mostly present in epidermal cells, particularly in trichoblasts.

INDUCTION: Transcripts levels decrease upon imbibition but remains stable at the protein level.

UniProt features for PHB4_ARATH » Prohibitin-4, mitochondrial
CHAIN 1 279 Prohibitin-4, mitochondrial.
Amino Acid Sequence for PHB4_ARATH » Prohibitin-4, mitochondrial
MGSQQVAISF LTNLAKAAFG LGVAATALNS SLYTVDGGER AVLFDRFRGV LDQTVGEGTH FLIPYLQTPH IYDIRTKPHT FSSKSGTKDL QMVNLTLRVL FRPEVSRLPY IFQTLGLEYD EKVLPSIGNE VLKAVVANFN ADQLLTERPQ VSALVRDALI KRAREFNIEL DDIAITHLSY GAEFSRAVEA KQVAQQEAER SKFVVMKADQ ERRAAVIRAE GESEAAQLIS DATAKAGMGL IELRRIEASR EVAATLARSP NVAYLPGGQS MLFNLNPGR