PHB2_YEAST » Prohibitin-2

PHB2_YEAST » Prohibitin-2
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Topology in Mitochondrial inner membrane
Topologyintermembrane space
mitochondrial matrix side
PHB2_YEAST » Prohibitin-2 »
Hydrophobic Thickness 28.2 ± 2.4 Å
Tilt Angle 23 ± 5°
ΔGtransfer -14.5 kcal/mol
ΔGfold -5.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology In
TM Segments 37-55 (37-59)
Pathways none
PDB none
OPM none
Complexes none
Interactions

AIM5, Complex: PHB2:AIM5, PubMed

ALG1, Complex: ALG1:PHB2

ANP1, Complex: PHB2:ANP1, PubMed

ATP18, Complex: PHB2:ATP18

BOS1, Complex: BOS1:PHB2

CSF1, Complex: PHB2:CSF1

EMP24, Complex: EMP24:PHB2, PubMed

ERP2, Complex: PHB2:ERP2, PubMed

FCJ1, Complex: PHB2:FCJ1, PubMed

FMP30, Complex: FMP30:PHB2

GEM1, Complex: PHB2:GEM1

GPI16, Complex: PHB2:GPI16

INA17, Complex: INA17:PHB2

JID1, Complex: PHB2:JID1

MDM38, Complex: MDM38:PHB2

MGR3, Complex: MGR3:PHB2

MMM1, Complex: PHB2:MMM1

MNN10, Complex: PHB2:MNN10, PubMed

MNN10, Complex: RL4B:EF1A:PDC1:ADH1:MPG1:FKS1:SNA2:PHB2:PHB1:MNN10, PubMed

MNN11, Complex: PHB2:MNN11, PubMed

MNN9, Complex: PHB2:MNN9, PubMed

MOS1, Complex: PHB2:MOS1, PubMed

PSD1, Complex: PSD1:PHB2

RMP1, Complex: RMP1:PHB2

TIM14, Complex: TIM14:PHB2

TSC10, Complex: PHB2:TSC10

UBC6, Complex: PHB2:UBC6

Domains

AA: 59-241, PDBID: 4FVF, Subunit A, Seq Identity:19%, SPFH domain / Band 7 family

UniProt annotation for PHB2_YEAST » Prohibitin-2
FUNCTION: Prohibitin probably acts as a holdase/unfoldase for the stabilization of newly synthesized mitochondrial proteins.

SUBUNIT: The mitochondrial prohibitin complex consists of two subunits (PHB1 and PHB2), assembled into a membrane-associated ring-shaped supercomplex of approximately 1 mDa.

MISCELLANEOUS: Present with 2850 molecules/cell in log phase SD medium.

MISCELLANEOUS: Mitochondrial targeting of PHB2 is ensured by a bipartite non-cleavable presequence at the N-terminus.

UniProt features for PHB2_YEAST » Prohibitin-2
CHAIN 1 310 Prohibitin-2.
COILED 212 253
Amino Acid Sequence for PHB2_YEAST » Prohibitin-2
MNRSPGEFQR YAKAFQKQLS KVQQTGGRGQ VPSPRGAFAG LGGLLLLGGG ALFINNALFN VDGGHRAIVY SRIHGVSSRI FNEGTHFIFP WLDTPIIYDV RAKPRNVASL TGTKDLQMVN ITCRVLSRPD VVQLPTIYRT LGQDYDERVL PSIVNEVLKA VVAQFNASQL ITQREKVSRL IRENLVRRAS KFNILLDDVS ITYMTFSPEF TNAVEAKQIA QQDAQRAAFV VDKARQEKQG MVVRAQGEAK SAELIGEAIK KSRDYVELKR LDTARDIAKI LASSPNRVIL DNEALLLNTV VDARIDGRGK