PEX25_YEAST » Peroxisomal membrane protein PEX25

PEX25_YEAST » Peroxisomal membrane protein PEX25
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Topology in Peroxisome membrane
Topologyperoxisome lumenal side
cytoplasmic side
PEX25_YEAST » Peroxisomal membrane protein PEX25 » Peroxin-25;
Hydrophobic Thickness 30.4 ± 3.1 Å
Tilt Angle 8 ± 3°
ΔGtransfer -12.6 kcal/mol
ΔGfold -3.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology In
TM Segments 365-385 (365-389)
Pathways none
PDB none
OPM none
Complexes none
Interactions

ANP1, Complex: PEX25:ANP1

FIS1, Complex: FIS1:PEX25

Domains

AA: 151-382, Peroxisomal biogenesis factor 11 (PEX11)

UniProt annotation for PEX25_YEAST » Peroxisomal membrane protein PEX25
FUNCTION: Required for regulation of peroxisome size and maintenance. Has a role in the import of peroxisomal matrix proteins. Imports RHO1 into the peroxisome. Also promotes peroxisome division and biogenesis.

SUBUNIT: Homooligomer. Interacts with PEX27 and PEX34.

MISCELLANEOUS: Present with 2420 molecules/cell in log phase SD medium.

UniProt features for PEX25_YEAST » Peroxisomal membrane protein PEX25
CHAIN 1 394 Peroxisomal membrane protein PEX25.
Amino Acid Sequence for PEX25_YEAST » Peroxisomal membrane protein PEX25
MSQFGTTDIV SGSETPPYSG ASYQDAQDDN THPHSSDAGA EKFSAGSGSE SHTESSRSDD EDSQAKTKMV DNITILKYIL DSLSGRDKLA KIIKYALDIL KLFIEKSKRN LTVLDPSVLT YYTKILKNLT VKVALRHPIT VIKVLLLSLL RNFDKKIDFI SQQLSTFRYI LRFGGTPFRV CSFLGKFNKT RKCNFQIDQI KKIWFNEASL REFLDLYYGI FDELDLLYKL KIWTNKSFYS FVSRQESLAW QYDILLSLKD HWLNLQSLQK RQLELEVQLK VQNNALLLSP ILMHQAHKDD GSQSPIRKQL LNDLNVNNDA EVLIHKQLKA IKDEKTLVYL DIARLSFDCM ANTSDILNLK TPKGTYAVLS LGSGLTGLVK LWITTKRSLC SSKD