PEX14_HUMAN » Peroxisomal membrane protein PEX14

PEX14_HUMAN » Peroxisomal membrane protein PEX14
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Topology in Peroxisome membrane
Topologyperoxisome lumenal side
cytoplasmic side
PEX14_HUMAN » Peroxisomal membrane protein PEX14 » PTS1 receptor-docking protein;Peroxin-14;Peroxisomal membrane anchor protein PEX14;
Hydrophobic Thickness 30.4 ± 2.7 Å
Tilt Angle 23 ± 0°
ΔGtransfer -14.5 kcal/mol
ΔGfold -11.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 109-130 (109-130)
Pathways none
PDB 4bxu (A=16-80), 2w85 (A=16-80), 2w84 (A=16-80)
OPM none
Complexes none
Interactions none
Domains

AA: 25-135, PDBID: 2W84, Subunit A, Seq Identity:100%, Peroxisomal membrane anchor protein (Pex14p) conserved region

UniProt annotation for PEX14_HUMAN » Peroxisomal membrane protein PEX14
FUNCTION: Peroxisome membrane protein that is an essential component of the peroxisomal import machinery. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PEX5). Plays a key role for peroxisome movement through a direct interaction with tubulin.
UniProt features for PEX14_HUMAN » Peroxisomal membrane protein PEX14
CHAIN 2 377 Peroxisomal membrane protein PEX14.
Amino Acid Sequence for PEX14_HUMAN » Peroxisomal membrane protein PEX14
MASSEQAEQP SQPSSTPGSE NVLPREPLIA TAVKFLQNSR VRQSPLATRR AFLKKKGLTD EEIDMAFQQS GTAADEPSSL GPATQVVPVQ PPHLISQPYS PAGSRWRDYG ALAIIMAGIA FGFHQLYKKY LLPLILGGRE DRKQLERMEA GLSELSGSVA QTVTQLQTTL ASVQELLIQQ QQKIQELAHE LAAAKATTST NWILESQNIN ELKSEINSLK GLLLNRRQFP PSPSAPKIPS WQIPVKSPSP SSPAAVNHHS SSDISPVSNE STSSSPGKEG HSPEGSTVTY HLLGPQEEGE GVVDVKGQVR MEVQGEEEKR EDKEDEEDEE DDDVSHVDEE DCLGVQREDR RGGDGQINEQ VEKLRRPEGA SNESERD