PERK4_ARATH » Proline-rich receptor-like protein kinase PERK4

PERK4_ARATH » Proline-rich receptor-like protein kinase PERK4
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PERK4_ARATH » Proline-rich receptor-like protein kinase PERK4 » Proline-rich extensin-like receptor kinase 4;AtPERK4;
Hydrophobic Thickness 30.4 ± 1.2 Å
Tilt Angle 0 ± 0°
ΔGtransfer -44.4 kcal/mol
ΔGfold -20.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology Out
TM Segments 150-172 (148-178)
Pathways none
PDB none
OPM none
Complexes none
Interactions

BETL2, Complex: PERK4:BETL2

CRK40, Complex: PERK4:CRK40

PAM74, Complex: PERK4:PAM74

UBC34, Complex: PERK4:UBC34

WAK3, Complex: PERK4:WAK3

Domains

AA: 284-556, PDBID: 1QPC, Subunit A, Seq Identity:43%, Protein tyrosine kinase

UniProt annotation for PERK4_ARATH » Proline-rich receptor-like protein kinase PERK4
FUNCTION: Required during abscisic acid (ABA)-mediated activation of Ca(2+) channels. Regulates ABA signaling pathways. Modulates the expression of genes related to cell elongation and ABA signaling during root growth.

CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.

ENZYME REGULATION: Activated by ABA and Ca(2+).

TISSUE SPECIFICITY: Mostly expressed in inflorescence bolts. Also present in roots, stems, germinated seeds, cotyledons, pollen, stamen and stigma.

INDUCTION: By ABA.

UniProt features for PERK4_ARATH » Proline-rich receptor-like protein kinase PERK4
CHAIN 1 633 Proline-rich receptor-like protein kinase PERK4.
DOMAIN 284 562 Protein kinase.
ACT_SITE 408 408 Proton acceptor (By similarity).
Amino Acid Sequence for PERK4_ARATH » Proline-rich receptor-like protein kinase PERK4
MASSPESAPP TNSTSSPSPP SNTNSTTSSP PAPSPPSPTP PQGDSSSSPP PDSTSPPAPQ APNPPNSSNN SPSPPSQGGG GERGNGGNNG GNDTPPSRGS PPSPPSRSNG DNGGSRSSPP GDTGGSRSDN PPSSGGSSGG GGGGRSNTNT AIIVGVLVGA GLLMIVLIIV CLRRKKKRKD SFYPEPMKGN QYQYYGNNNN NNASQNYPNW HLNSQGQNQQ STGGWGGGGP SPPPPPRMPT SGEDSSMYSG PSRPVLPPPS PALALGFNKS TFTYQELAAA TGGFTDANLL GQGGFGYVHK GVLPSGKEVA VKSLKAGSGQ GEREFQAEVD IISRVHHRYL VSLVGYCIAD GQRMLVYEFV PNKTLEYHLH GKNLPVMEFS TRLRIALGAA KGLAYLHEDC HPRIIHRDIK SANILLDFNF DAMVADFGLA KLTSDNNTHV STRVMGTFGY LAPEYASSGK LTEKSDVFSY GVMLLELITG KRPVDNSITM DDTLVDWARP LMARALEDGN FNELADARLE GNYNPQEMAR MVTCAAASIR HSGRKRPKMS QIVRALEGEV SLDALNEGVK PGHSNVYGSL GASSDYSQTS YNADMKKFRQ IALSSQEFPV SDCEGTSSND SRDMGTKSPT PPK