PEP12_YEAST » Syntaxin PEP12

PEP12_YEAST » Syntaxin PEP12
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PEP12_YEAST » Syntaxin PEP12 » Carboxypeptidase Y-deficient protein 12;Vacuolar protein sorting-associated protein 6;Vacuolar protein-targeting protein 13;
Hydrophobic Thickness 31.6 ± 2.7 Å
Tilt Angle 6 ± 3°
ΔGtransfer -27.2 kcal/mol
ΔGfold -24.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology In
TM Segments 267-287 (263-287)
Pathways

Phagosome (KEGG)

SNARE interactions in vesicular transport (KEGG)

PDB none
OPM none
Complexes none
Interactions

GOSR1, Complex: PEP12:GOSR1, PubMed

LOA1, Complex: PEP12:LOA1

MCP2, Complex: PEP12:MCP2

MID2, Complex: PEP12:MID2

MTC4, Complex: PEP12:MTC4

PPB, Complex: PPB:PEP12

SED5, Complex: SED5:PEP12, PubMed

SFT1, Complex: PEP12:SFT1, PubMed

SNC1, Complex: PEP12:SNC1, PubMed

SNC1, Complex: YKT6:VTI1:PEP12:STX8:SNC1, PubMed

SNC2, Complex: PEP12:SNC2

STX8, Complex: PEP12:STX8, PubMed

STX8, Complex: RSSA1:PDC1:ADH1:FKS1:HSP72:HSP75:GCN1:EF3A:GBB:AKR1:YKT6:VTI1:PEP12:STX8, PubMed

TLG1, Complex: TLG1:PEP12, PubMed

VAM3, Complex: PEP12:VAM3

VTI1, Complex: VTI1:PEP12, PubMed

Domains

AA: 33-141, PDBID: 2DNX, Subunit A, Seq Identity:17%, Syntaxin-like protein

AA: 231-283, PDBID: 4XTR, Subunit G, Seq Identity:100%, SNARE domain

UniProt annotation for PEP12_YEAST » Syntaxin PEP12
FUNCTION: Plays a role in the sorting and targeting of vacuolar proteases.
UniProt features for PEP12_YEAST » Syntaxin PEP12
CHAIN 1 288 Syntaxin PEP12.
DOMAIN 195 257 t-SNARE coiled-coil homology.
Amino Acid Sequence for PEP12_YEAST » Syntaxin PEP12
MSEDEFFGGD NEAVWNGSRF SDSPEFQTLK EEVAAELFEI NGQISTLQQF TATLKSFIDR GDVSAKVVER INKRSVAKIE EIGGLIKKVN TSVKKMDAIE EASLDKTQII AREKLVRDVS YSFQEFQGIQ RQFTQVMKQV NERAKESLEA SEMANDAALL DEEQRQNSSK STRIPGSQIV IERDPINNEE FAYQQNLIEQ RDQEISNIER GITELNEVFK DLGSVVQQQG VLVDNIEANI YTTSDNTQLA SDELRKAMRY QKRTSRWRVY LLIVLLVMLL FIFLIMKL