PEAR1_HUMAN » Platelet endothelial aggregation receptor 1

PEAR1_HUMAN » Platelet endothelial aggregation receptor 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PEAR1_HUMAN » Platelet endothelial aggregation receptor 1 » hPEAR1; Multiple epidermal growth factor-like domains protein 12;Multiple EGF-like domains protein 12;
Hydrophobic Thickness 33.6 ± 2.4 Å
Tilt Angle 0 ± 0°
ΔGtransfer -40.0 kcal/mol
ΔGfold -19.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 755-779 (754-785)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 276-321, PDBID: 1KLO, Subunit A, Seq Identity:32%, Laminin EGF domain

AA: 319-362, PDBID: 4OVE, Subunit A, Seq Identity:40%, Laminin EGF domain

AA: 537-582, PDBID: 1KLO, Subunit A, Seq Identity:30%, Laminin EGF domain

AA: 622-667, PDBID: 3ZYJ, Subunit D, Seq Identity:40%, Laminin EGF domain

UniProt annotation for PEAR1_HUMAN » Platelet endothelial aggregation receptor 1
FUNCTION: When overexpressed, reduces the number of both early and late non-adherent myeloid progenitor cells.

SUBUNIT: Interacts with SHC2 upon its aggregation-induced tyrosine phosphorylation.

TISSUE SPECIFICITY: Expressed in umbilical vein endothelial cells and platelets (at protein level). Expressed in heart, kidney, skeletal muscle, pancreas, ovary, breast, lung, brain cortex, hypothalamus, spinal cord, dorsal root ganglion, endothelial cells of umbilical cord artery and vein, megakaryocytes, osteoblasts, coronary muscle and erythroid cells. Weakly expressed in peripheral blood leukocytes and macrophages.

UniProt features for PEAR1_HUMAN » Platelet endothelial aggregation receptor 1
SIGNAL 1 20 Potential.
CHAIN 21 1037 Platelet endothelial aggregation receptor 1.
DOMAIN 25 103 EMI.
DOMAIN 102 132 EGF-like 1.
DOMAIN 225 260 EGF-like 2.
DOMAIN 268 303 EGF-like 3.
DOMAIN 311 346 EGF-like 4.
DOMAIN 400 435 EGF-like 5.
DOMAIN 486 521 EGF-like 6.
DOMAIN 577 607 EGF-like 7.
DOMAIN 615 649 EGF-like 8.
DOMAIN 657 692 EGF-like 9.
DISULFID 29 91 Potential.
DISULFID 55 65 Potential.
DISULFID 90 101 Potential.
DISULFID 105 114 By similarity.
DISULFID 109 120 By similarity.
DISULFID 122 131 By similarity.
DISULFID 235 248 By similarity.
DISULFID 250 259 By similarity.
DISULFID 272 284 By similarity.
DISULFID 278 291 By similarity.
DISULFID 293 302 By similarity.
DISULFID 315 327 By similarity.
DISULFID 321 334 By similarity.
DISULFID 336 345 By similarity.
DISULFID 404 416 By similarity.
DISULFID 410 423 By similarity.
DISULFID 425 434 By similarity.
DISULFID 490 502 By similarity.
DISULFID 496 509 By similarity.
DISULFID 511 520 By similarity.
DISULFID 580 588 By similarity.
DISULFID 582 595 By similarity.
DISULFID 597 606 By similarity.
DISULFID 619 630 By similarity.
DISULFID 624 637 By similarity.
DISULFID 639 648 By similarity.
DISULFID 661 673 By similarity.
DISULFID 667 680 By similarity.
DISULFID 682 691 By similarity.
Amino Acid Sequence for PEAR1_HUMAN » Platelet endothelial aggregation receptor 1
MSPPLCPLLL LAVGLRLAGT LNPSDPNTCS FWESFTTTTK ESHSRPFSLL PSEPCERPWE GPHTCPQPTV VYRTVYRQVV KTDHRQRLQC CHGFYESRGF CVPLCAQECV HGRCVAPNQC QCVPGWRGDD CSSECAPGMW GPQCDKPCSC GNNSSCDPKS GVCSCPSGLQ PPNCLQPCTP GYYGPACQFR CQCHGAPCDP QTGACFCPAE RTGPSCDVSC SQGTSGFFCP STHSCQNGGV FQTPQGSCSC PPGWMGTICS LPCPEGFHGP NCSQECRCHN GGLCDRFTGQ CRCAPGYTGD RCREECPVGR FGQDCAETCD CAPDARCFPA NGACLCEHGF TGDRCTDRLC PDGFYGLSCQ APCTCDREHS LSCHPMNGEC SCLPGWAGLH CNESCPQDTH GPGCQEHCLC LHGGVCQATS GLCQCAPGYT GPHCASLCPP DTYGVNCSAR CSCENAIACS PIDGECVCKE GWQRGNCSVP CPPGTWGFSC NASCQCAHEA VCSPQTGACT CTPGWHGAHC QLPCPKGQFG EGCASRCDCD HSDGCDPVHG RCQCQAGWMG ARCHLSCPEG LWGVNCSNTC TCKNGGTCLP ENGNCVCAPG FRGPSCQRSC QPGRYGKRCV PCKCANHSFC HPSNGTCYCL AGWTGPDCSQ PCPPGHWGEN CAQTCQCHHG GTCHPQDGSC ICPLGWTGHH CLEGCPLGTF GANCSQPCQC GPGEKCHPET GACVCPPGHS GAPCRIGIQE PFTVMPTTPV AYNSLGAVIG IAVLGSLVVA LVALFIGYRH WQKGKEHHHL AVAYSSGRLD GSEYVMPDVP PSYSHYYSNP SYHTLSQCSP NPPPPNKVPG PLFASLQNPE RPGGAQGHDN HTTLPADWKH RREPPPGPLD RGSSRLDRSY SYSYSNGPGP FYNKGLISEE ELGASVASLS SENPYATIRD LPSLPGGPRE SSYMEMKGPP SGSPPRQPPQ FWDSQRRRQP QPQRDSGTYE QPSPLIHDRD SVGSQPPLPP GLPPGHYDSP KNSHIPGHYD LPPVRHPPSP PLRRQDR