PDXL2_HUMAN » Podocalyxin-like protein 2

PDXL2_HUMAN » Podocalyxin-like protein 2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PDXL2_HUMAN » Podocalyxin-like protein 2 » Endoglycan;
Hydrophobic Thickness 35.6 ± 3.0 Å
Tilt Angle 0 ± 0°
ΔGtransfer -46.3 kcal/mol
ΔGfold -25.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 497-522 (497-529)
Pathways none
PDB none
OPM none
Complexes none
Interactions

LYAM1, Complex: LYAM1:PDXL2, PubMed

Domains

AA: 393-605, CD34/Podocalyxin family

UniProt annotation for PDXL2_HUMAN » Podocalyxin-like protein 2
FUNCTION: Acts as a ligand for vascular selectins. Mediates rapid rolling of leukocytes over vascular surfaces through high affinity divalent cation-dependent interactions with E-, P- and L- selectins.

SUBUNIT: Homodimer; disulfide-linked. Interacts with SELL, SELE and SELP.

TISSUE SPECIFICITY: Expressed in T-cells, B-cells and monocytes. Expression is higher on memory and germinal center cells than on naive B-cells (at protein level). Highly expressed in brain. Moderately expressed in pancreas, kidney and lymphoid node. Weakly expressed in liver. Detected in both endothelial cells and CD34+ bone marrow cells.

UniProt features for PDXL2_HUMAN » Podocalyxin-like protein 2
SIGNAL 1 32 Potential.
CHAIN 33 605 Podocalyxin-like protein 2.
REGION 129 134 O-glycosylated at one site.
Amino Acid Sequence for PDXL2_HUMAN » Podocalyxin-like protein 2
MGRLLRAARL PPLLSPLLLL LVGGAFLGAC VAGSDEPGPE GLTSTSLLDL LLPTGLEPLD SEEPSETMGL GAGLGAPGSG FPSEENEESR ILQPPQYFWE EEEELNDSSL DLGPTADYVF PDLTEKAGSI EDTSQAQELP NLPSPLPKMN LVEPPWHMPP REEEEEEEEE EEREKEEVEK QEEEEEEELL PVNGSQEEAK PQVRDFSLTS SSQTPGATKS RHEDSGDQAS SGVEVESSMG PSLLLPSVTP TTVTPGDQDS TSQEAEATVL PAAGLGVEFE APQEASEEAT AGAAGLSGQH EEVPALPSFP QTTAPSGAEH PDEDPLGSRT SASSPLAPGD MELTPSSATL GQEDLNQQLL EGQAAEAQSR IPWDSTQVIC KDWSNLAGKN YIILNMTENI DCEVFRQHRG PQLLALVEEV LPRHGSGHHG AWHISLSKPS EKEQHLLMTL VGEQGVVPTQ DVLSMLGDIR RSLEEIGIQN YSTTSSCQAR ASQVRSDYGT LFVVLVVIGA ICIIIIALGL LYNCWQRRLP KLKHVSHGEE LRFVENGCHD NPTLDVASDS QSEMQEKHPS LNGGGALNGP GSWGALMGGK RDPEDSDVFE EDTHL