PDPN_HUMAN » Podoplanin

PDPN_HUMAN » Podoplanin
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PDPN_HUMAN » Podoplanin » Aggrus;Glycoprotein 36;Gp36; PA2.26 antigen;T1-alpha;T1A;
Hydrophobic Thickness 32.8 ± 1.0 Å
Tilt Angle 0 ± 2°
ΔGtransfer -48.2 kcal/mol
ΔGfold -23.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 128-156 (128-157)
Pathways none
PDB 3wsr (C/D=38-54)
OPM none
Complexes

PDPN:CLC1B_HUMAN

Interactions

CLC1B, Complex: PDPN:CLC1B, PDBID: 3WSR

Domains

AA: 1-161, PDBID: 3WSR, Subunit D, Seq Identity:100%, Podoplanin

UniProt annotation for PDPN_HUMAN » Podoplanin
FUNCTION: May be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Required for normal lung cell proliferation and alveolus formation at birth. Induces platelet aggregation. Does not have any effect on folic acid or amino acid transport. Does not function as a water channel or as a regulator of aquaporin-type water channels.

TISSUE SPECIFICITY: Highly expressed in placenta, lung, skeletal muscle and brain. Weakly expressed in brain, kidney and liver. In placenta, expressed on the apical plasma membrane of endothelium. In lung, expressed in alveolar epithelium. Up-regulated in colorectal tumors and expressed in 25% of early oral squamous cell carcinomas.

UniProt features for PDPN_HUMAN » Podoplanin
SIGNAL 1 22 Potential.
CHAIN 23 162 Podoplanin.
Amino Acid Sequence for PDPN_HUMAN » Podoplanin
MWKVSALLFV LGSASLWVLA EGASTGQPED DTETTGLEGG VAMPGAEDDV VTPGTSEDRY KSGLTTLVAT SVNSVTGIRI EDLPTSESTV HAQEQSPSAT ASNVATSHST EKVDGDTQTT VEKDGLSTVT LVGIIVGVLL AIGFIGAIIV VVMRKMSGRY SP