PDCD1_HUMAN » Programmed cell death protein 1

PDCD1_HUMAN » Programmed cell death protein 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PDCD1_HUMAN » Programmed cell death protein 1 » Protein PD-1; hPD-1;
Hydrophobic Thickness 42.0 ± 1.6 Å
Tilt Angle 0 ± 0°
ΔGtransfer -55.3 kcal/mol
ΔGfold -17.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 165-192 (165-197)
Pathways

Cell adhesion molecules (KEGG)

Immune System (Reactome)

T cell receptor signaling pathway (KEGG)

PDB 3rrq (32-160), 2m2d (34-150)
OPM none
Complexes

PD1L2:PDCD1_MOUSE

PDCD1:PD1L1_HUMAN

Interactions

PD1L1, Complex: PD1L1:PDCD1, PDBID: 3bik, PubMed

PD1L2, Complex: PD1L2:PDCD1, PDBID: 3bp5, PubMed

Domains

AA: 37-145, PDBID: 2M2D, Subunit A, Seq Identity:100%, Immunoglobulin V-set domain

UniProt annotation for PDCD1_HUMAN » Programmed cell death protein 1
FUNCTION: Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen- specific manner. Possible cell death inducer, in association with other factors.

SUBUNIT: Monomer.

DEVELOPMENTAL STAGE: Induced at programmed cell death.

DISEASE: Systemic lupus erythematosus 2 (SLEB2) OMIM: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

UniProt features for PDCD1_HUMAN » Programmed cell death protein 1
SIGNAL 1 20 Potential.
CHAIN 21 288 Programmed cell death protein 1.
DOMAIN 35 145 Ig-like V-type.
DISULFID 54 123 By similarity.
Amino Acid Sequence for PDCD1_HUMAN » Programmed cell death protein 1
MQIPQAPWPV VWAVLQLGWR PGWFLDSPDR PWNPPTFSPA LLVVTEGDNA TFTCSFSNTS ESFVLNWYRM SPSNQTDKLA AFPEDRSQPG QDCRFRVTQL PNGRDFHMSV VRARRNDSGT YLCGAISLAP KAQIKESLRA ELRVTERRAE VPTAHPSPSP RPAGQFQTLV VGVVGGLLGS LVLLVWVLAV ICSRAARGTI GARRTGQPLK EDPSAVPVFS VDYGELDFQW REKTPEPPVP CVPEQTEYAT IVFPSGMGTS SPARRGSADG PRSAQPLRPE DGHCSWPL