PD1L2_HUMAN » Programmed cell death 1 ligand 2

PD1L2_HUMAN » Programmed cell death 1 ligand 2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PD1L2_HUMAN » Programmed cell death 1 ligand 2 » PD-1 ligand 2; PD-L2; PDCD1 ligand 2; Programmed death ligand 2; Butyrophilin B7-DC;B7-DC;
Hydrophobic Thickness 34.0 ± 2.4 Å
Tilt Angle 25 ± 19°
ΔGtransfer -28.1 kcal/mol
ΔGfold -21.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 219-243 (219-245)
Pathways

Cell adhesion molecules (KEGG)

Immune System (Reactome)

PDB none
OPM none
Complexes

PD1L2:PDCD1_MOUSE

Interactions

PDCD1, Complex: PD1L2:PDCD1, PDBID: 3bp5, PubMed

Domains

AA: 22-105, PDBID: 3MJG, Subunit X, Seq Identity:25%, Immunoglobulin domain

AA: 125-202, PDBID: 3BP5, Subunit B, Seq Identity:69%, CD80-like C2-set immunoglobulin domain

UniProt annotation for PD1L2_HUMAN » Programmed cell death 1 ligand 2
FUNCTION: Involved in the costimulatory signal, essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production (By similarity).

SUBUNIT: Interacts with PDCD1.

TISSUE SPECIFICITY: Highly expressed in heart, placenta, pancreas, lung and liver and weakly expressed in spleen, lymph nodes and thymus.

INDUCTION: Up-regulated by IFNG/IFN-gamma stimulation in monocytes and induced on dendritic cells grown from peripheral blood mononuclear cells with CSF2 and IL4/interleukin-4.

UniProt features for PD1L2_HUMAN » Programmed cell death 1 ligand 2
SIGNAL 1 19
CHAIN 20 273 Programmed cell death 1 ligand 2.
DOMAIN 21 118 Ig-like V-type.
DOMAIN 122 203 Ig-like C2-type.
DISULFID 42 102 By similarity.
DISULFID 143 192 By similarity.
Amino Acid Sequence for PD1L2_HUMAN » Programmed cell death 1 ligand 2
MIFLLLMLSL ELQLHQIAAL FTVTVPKELY IIEHGSNVTL ECNFDTGSHV NLGAITASLQ KVENDTSPHR ERATLLEEQL PLGKASFHIP QVQVRDEGQY QCIIIYGVAW DYKYLTLKVK ASYRKINTHI LKVPETDEVE LTCQATGYPL AEVSWPNVSV PANTSHSRTP EGLYQVTSVL RLKPPPGRNF SCVFWNTHVR ELTLASIDLQ SQMEPRTHPT WLLHIFIPFC IIAFIFIATV IALRKQLCQK LYSSKDTTKR PVTTTKREVN SAI