PD1L1_HUMAN » Programmed cell death 1 ligand 1

PD1L1_HUMAN » Programmed cell death 1 ligand 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PD1L1_HUMAN » Programmed cell death 1 ligand 1 » PD-L1; PDCD1 ligand 1; Programmed death ligand 1; B7 homolog 1;B7-H1;
Hydrophobic Thickness 31.6 ± 2.4 Å
Tilt Angle 2 ± 2°
ΔGtransfer -39.0 kcal/mol
ΔGfold -20.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 239-261 (235-263)
Pathways

Cell adhesion molecules (KEGG)

Immune System (Reactome)

PDB 3bis (18-239), 3fn3 (A/B=19-238), 3bik (A=18-239), 3sbw (C=19-239)
OPM none
Complexes

PDCD1:PD1L1_HUMAN

PD1L1:PD1L1_HUMAN

Interactions

CD80, Complex: PD1L1:CD80

PD1L1, Complex: Homodimer of programmed cell death 1 ligand 1, PDBID: 3FN3

PDCD1, Complex: PD1L1:PDCD1, PDBID: 3bik, PubMed

Domains

AA: 22-131, PDBID: 3BIK, Subunit A, Seq Identity:100%, Immunoglobulin V-set domain

AA: 135-220, PDBID: 3BIK, Subunit A, Seq Identity:100%, CD80-like C2-set immunoglobulin domain

UniProt annotation for PD1L1_HUMAN » Programmed cell death 1 ligand 1
FUNCTION: Involved in the costimulatory signal, essential for T- cell proliferation and production of IL10 and IFNG, in an IL2- dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.

SUBUNIT: Interacts with PDCD1.

TISSUE SPECIFICITY: Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes.

INDUCTION: Up-regulated on T- and B-cells, dendritic cells, keratinocytes and monocytes after LPS and IFNG activation. Up- regulated in B-cells activated by surface Ig cross-linking.

UniProt features for PD1L1_HUMAN » Programmed cell death 1 ligand 1
SIGNAL 1 18 Potential.
CHAIN 19 290 Programmed cell death 1 ligand 1.
DOMAIN 19 127 Ig-like V-type.
DOMAIN 133 225 Ig-like C2-type.
DISULFID 40 114
DISULFID 155 209
Amino Acid Sequence for PD1L1_HUMAN » Programmed cell death 1 ligand 1
MRIFAVFIFM TYWHLLNAFT VTVPKDLYVV EYGSNMTIEC KFPVEKQLDL AALIVYWEME DKNIIQFVHG EEDLKVQHSS YRQRARLLKD QLSLGNAALQ ITDVKLQDAG VYRCMISYGG ADYKRITVKV NAPYNKINQR ILVVDPVTSE HELTCQAEGY PKAEVIWTSS DHQVLSGKTT TTNSKREEKL FNVTSTLRIN TTTNEIFYCT FRRLDPEENH TAELVIPELP LAHPPNERTH LVILGAILLC LGVALTFIFR LRKGRMMDVK KCGIQDTNSK KQSDTHLEET