PCDH8_HUMAN » Protocadherin-8

PCDH8_HUMAN » Protocadherin-8
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PCDH8_HUMAN » Protocadherin-8 » Arcadlin;
Hydrophobic Thickness 40.0 ± 4.8 Å
Tilt Angle 0 ± 0°
ΔGtransfer -25.6 kcal/mol
ΔGfold -24.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 748-774 (747-780)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 31-111, PDBID: 4ZPL, Subunit A, Seq Identity:36%, Cadherin-like

AA: 140-236, PDBID: 4ZI8, Subunit B, Seq Identity:47%, Cadherin domain

AA: 251-345, PDBID: 4ZPM, Subunit A, Seq Identity:44%, Cadherin domain

AA: 398-488, PDBID: 4ZPL, Subunit A, Seq Identity:36%, Cadherin domain

AA: 502-600, PDBID: 4ZPL, Subunit A, Seq Identity:37%, Cadherin domain

AA: 619-711, PDBID: 4ZI8, Subunit B, Seq Identity:29%, Cadherin domain

UniProt annotation for PCDH8_HUMAN » Protocadherin-8
FUNCTION: Calcium-dependent cell-adhesion protein (By similarity). May play a role in activity-induced synaptic reorganization underlying long term memory (By similarity). Could be involved in CDH2 internalization through TAOK2/p38 MAPK pathway. In hippocampal neurons, may play a role in the down-regulation of dendritic spines, maybe through its action on CDH2 endocytosis (By similarity).

SUBUNIT: The N-terminal extracellular domain forms homophilic interactions; these interactions activate p38 MAPK via TAOK2 and trigger endocytosis. Interacts with CDH2; this interaction may lead to CDH2 cointernalization. Interacts with CDH11. Interacts with TAOK2.

UniProt features for PCDH8_HUMAN » Protocadherin-8
SIGNAL 1 29 Potential.
CHAIN 30 1070 Protocadherin-8.
DOMAIN 30 135 Cadherin 1.
DOMAIN 136 245 Cadherin 2.
DOMAIN 247 354 Cadherin 3.
DOMAIN 393 497 Cadherin 4.
DOMAIN 498 609 Cadherin 5.
DOMAIN 615 723 Cadherin 6.
Amino Acid Sequence for PCDH8_HUMAN » Protocadherin-8
MSPVRRWGSP CLFPLQLFSL CWVLSVAQSK TVRYSTFEED APGTVIGTLA EDLHMKVSGD TSFRLMKQFN SSLLRVREGD GQLTVGDAGL DRERLCGQAP QCVLAFDVVS FSQEQFRLVH VEVEVRDVND HAPRFPRAQI PVEVSEGAAV GTRIPLEVPV DEDVGANGLQ TVRLAEPHSP FRVELQTRAD GAQCADLVLL QELDRESQAA YSLELVAQDG GRPPRSATAA LSVRVLDAND HSPAFPQGAV AEVELAEDAP VGSLLLDLDA ADPDEGPNGD VVFAFGARTP PEARRLFRLD PRSGRLTLAG PVDYERQDTY ELDVRAQDRG PGPRAATCKV IVRIRDVNDN APDIAITPLA APGAPATSPF AAAAAAAALG GADASSPAGA GTPEAGATSL VPEGAARESL VALVSTSDRD SGANGQVRCA LYGHEHFRLQ PAYAGSYLVV TAASLDRERI AEYNLTLVAE DRGAPPLRTV RPYTVRVGDE NDNAPLFTRP VYEVSVRENN PPGAYLATVA ARDRDLGRNG QVTYRLLEAE VGRAGGAVST YVSVDPATGA IYALRSFDYE TLRQLDVRIQ ASDGGSPQLS SSALVQVRVL DQNDHAPVLV HPAPANGSLE VAVPGRTAKD TVVARVQARD ADEGANGELA FELQQQEPRE AFAIGRRTGE ILLTGDLSQE PPGRVFRALL VISDGGRPPL TTTATVSFVV TAGGGRGPAA PASAGSPERS RPPGSRLGVS GSVLQWDTPL IVIIVLAGSC TLLLAAIIAI ATTCNRRKKE VRKGGALREE RPGAAGGGAS APGSPEEAAR GAGPRPNMFD VLTFPGTGKA PFGSPAADAP PPAVAAAEVP GSEGGSATGE SACHFEGQQR LRGAHAEPYG ASPGFGKEPA PPVAVWKGHS FNTISGREAE KFSGKDSGKG DSDFNDSDSD ISGDALKKDL INHMQSGLWA CTAECKILGH SDRCWSPSCS GPNAHPSPHP PAQMSTFCKS TSLPRDPLRR DNYYQAQLPK TVGLQSVYEK VLHRDYDRTV TLLSPPRPGR LPDLQEIGVP LYQSPPGRYL SPKKGANENV