PCDH7_HUMAN » Protocadherin-7

PCDH7_HUMAN » Protocadherin-7
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PCDH7_HUMAN » Protocadherin-7 » Brain-heart protocadherin;BH-Pcdh;
Hydrophobic Thickness 36.0 ± 1.8 Å
Tilt Angle 1 ± 0°
ΔGtransfer -57.1 kcal/mol
ΔGfold -28.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 878-900 (871-907)
Pathways none
PDB 2yst (302-413)
OPM none
Complexes none
Interactions

RYK, Complex: PCDH7:RYK, PubMed

Domains

AA: 33-117, PDBID: 4ZPM, Subunit B, Seq Identity:31%, Cadherin-like

AA: 238-299, PDBID: 4ZPL, Subunit A, Seq Identity:21%, Cadherin domain

AA: 313-406, PDBID: 2YST, Subunit A, Seq Identity:100%, Cadherin domain

AA: 429-526, PDBID: 4ZPL, Subunit A, Seq Identity:34%, Cadherin domain

AA: 540-630, PDBID: 3UBH, Subunit A, Seq Identity:41%, Cadherin domain

AA: 644-733, PDBID: 3PPE, Subunit A, Seq Identity:34%, Cadherin domain

AA: 752-840, PDBID: 4ZI8, Subunit B, Seq Identity:31%, Cadherin domain

AA: 842-1055, Protocadherin

UniProt annotation for PCDH7_HUMAN » Protocadherin-7
TISSUE SPECIFICITY: Expressed predominantly in brain and heart and at lower levels in various other tissues.
UniProt features for PCDH7_HUMAN » Protocadherin-7
SIGNAL 1 28 Potential.
CHAIN 29 1069 Protocadherin-7.
DOMAIN 29 143 Cadherin 1.
DOMAIN 144 308 Cadherin 2.
DOMAIN 309 415 Cadherin 3.
DOMAIN 424 535 Cadherin 4.
DOMAIN 536 639 Cadherin 5.
DOMAIN 640 742 Cadherin 6.
DOMAIN 745 862 Cadherin 7.
Amino Acid Sequence for PCDH7_HUMAN » Protocadherin-7
MLRMRTAGWA RGWCLGCCLL LPLSLSLAAA KQLLRYRLAE EGPADVRIGN VASDLGIVTG SGEVTFSLES GSEYLKIDNL TGELSTSERR IDREKLPQCQ MIFDENECFL DFEVSVIGPS QSWVDLFEGQ VIVLDINDNT PTFPSPVLTL TVEENRPVGT LYLLPTATDR DFGRNGIERY ELLQEPGGGG SGGESRRAGA ADSAPYPGGG GNGASGGGSG GSKRRLDASE GGGGTNPGGR SSVFELQVAD TPDGEKQPQL IVKGALDREQ RDSYELTLRV RDGGDPPRSS QAILRVLITD VNDNSPRFEK SVYEADLAEN SAPGTPILQL RAADLDVGVN GQIEYVFGAA TESVRRLLRL DETSGWLSVL HRIDREEVNQ LRFTVMARDR GQPPKTDKAT VVLNIKDEND NVPSIEIRKI GRIPLKDGVA NVAEDVLVDT PIALVQVSDR DQGENGVVTC TVVGDVPFQL KPASDTEGDQ NKKKYFLHTS TPLDYEATRE FNVVIVAVDS GSPSLSSNNS LIVKVGDTND NPPMFGQSVV EVYFPENNIP GERVATVLAT DADSGKNAEI AYSLDSSVMG IFAIDPDSGD ILVNTVLDRE QTDRYEFKVN AKDKGIPVLQ GSTTVIVQVA DKNDNDPKFM QDVFTFYVKE NLQPNSPVGM VTVMDADKGR NAEMSLYIEE NNNIFSIEND TGTIYSTMSF DREHQTTYTF RVKAVDGGDP PRSATATVSL FVMDENDNAP TVTLPKNISY TLLPPSSNVR TVVATVLATD SDDGINADLN YSIVGGNPFK LFEIDPTSGV VSLVGKLTQK HYGLHRLVVQ VNDSGQPSQS TTTLVHVFVN ESVSNATAID SQIARSLHIP LTQDIAGDPS YEISKQRLSI VIGVVAGIMT VILIILIVVM ARYCRSKNKN GYEAGKKDHE DFFTPQQHDK SKKPKKDKKN KKSKQPLYSS IVTVEASKPN GQRYDSVNEK LSDSPSMGRY RSVNGGPGSP DLARHYKSSS PLPTVQLHPQ SPTAGKKHQA VQDLPPANTF VGAGDNISIG SDHCSEYSCQ TNNKYSKQMR LHPYITVFG