PCDH1_HUMAN » Protocadherin-1

PCDH1_HUMAN » Protocadherin-1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PCDH1_HUMAN » Protocadherin-1 » Cadherin-like protein 1;Protocadherin-42;PC42;
Hydrophobic Thickness 34.4 ± 4.0 Å
Tilt Angle 29 ± 1°
ΔGtransfer -27.5 kcal/mol
ΔGfold -24.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 851-877 (843-880)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 59-142, PDBID: 4ZPL, Subunit A, Seq Identity:32%, Cadherin-like

AA: 173-271, PDBID: 4ZPL, Subunit A, Seq Identity:40%, Cadherin domain

AA: 285-378, PDBID: 2YST, Subunit A, Seq Identity:51%, Cadherin domain

AA: 401-497, PDBID: 4ZPL, Subunit A, Seq Identity:29%, Cadherin domain

AA: 511-603, PDBID: 2EE0, Subunit A, Seq Identity:39%, Cadherin domain

AA: 617-706, PDBID: 3PPE, Subunit A, Seq Identity:31%, Cadherin domain

AA: 727-813, PDBID: 3UBH, Subunit A, Seq Identity:30%, Cadherin domain

AA: 815-1029, Protocadherin

UniProt annotation for PCDH1_HUMAN » Protocadherin-1
FUNCTION: May be involved in cell-cell interaction processes and in cell adhesion.

TISSUE SPECIFICITY: Highly expressed in the brain and neuro-glial cells.

DEVELOPMENTAL STAGE: Highest expression in adults.

UniProt features for PCDH1_HUMAN » Protocadherin-1
SIGNAL 1 57 Potential.
CHAIN 58 1060 Protocadherin-1.
DOMAIN 58 168 Cadherin 1.
DOMAIN 169 280 Cadherin 2.
DOMAIN 281 387 Cadherin 3.
DOMAIN 396 506 Cadherin 4.
DOMAIN 507 612 Cadherin 5.
DOMAIN 613 715 Cadherin 6.
DOMAIN 718 844 Cadherin 7.
Amino Acid Sequence for PCDH1_HUMAN » Protocadherin-1
MDSGAGGRRC PEAALLILGP PRMEHLRHSP GPGGQRLLLP SMLLALLLLL APSPGHATRV VYKVPEEQPP NTLIGSLAAD YGFPDVGHLY KLEVGAPYLR VDGKTGDIFT TETSIDREGL RECQNQLPGD PCILEFEVSI TDLVQNGSPR LLEGQIEVQD INDNTPNFAS PVITLAIPEN TNIGSLFPIP LASDRDAGPN GVASYELQAG PEAQELFGLQ VAEDQEEKQP QLIVMGNLDR ERWDSYDLTI KVQDGGSPPR ASSALLRVTV LDTNDNAPKF ERPSYEAELS ENSPIGHSVI QVKANDSDQG ANAEIEYTFH QAPEVVRRLL RLDRNTGLIT VQGPVDREDL STLRFSVLAK DRGTNPKSAR AQVVVTVKDM NDNAPTIEIR GIGLVTHQDG MANISEDVAE ETAVALVQVS DRDEGENAAV TCVVAGDVPF QLRQASETGS DSKKKYFLQT TTPLDYEKVK DYTIEIVAVD SGNPPLSSTN SLKVQVVDVN DNAPVFTQSV TEVAFPENNK PGEVIAEITA SDADSGSNAE LVYSLEPEPA AKGLFTISPE TGEIQVKTSL DREQRESYEL KVVAADRGSP SLQGTATVLV NVLDCNDNDP KFMLSGYNFS VMENMPALSP VGMVTVIDGD KGENAQVQLS VEQDNGDFVI QNGTGTILSS LSFDREQQST YTFQLKAVDG GVPPRSAYVG VTINVLDEND NAPYITAPSN TSHKLLTPQT RLGETVSQVA AEDFDSGVNA ELIYSIAGGN PYGLFQIGSH SGAITLEKEI ERRHHGLHRL VVKVSDRGKP PRYGTALVHL YVNETLANRT LLETLLGHSL DTPLDIDIAG DPEYERSKQR GNILFGVVAG VVAVALLIAL AVLVRYCRQR EAKSGYQAGK KETKDLYAPK PSGKASKGNK SKGKKSKSPK PVKPVEDEDE AGLQKSLKFN LMSDAPGDSP RIHLPLNYPP GSPDLGRHYR SNSPLPSIQL QPQSPSASKK HQVVQDLPPA NTFVGTGDTT STGSEQYSDY SYRTNPPKYP SKQVGQPFQL STPQPLPHPY HGAIWTEVWE