PCDGM_HUMAN » Protocadherin gamma-C5

PCDGM_HUMAN » Protocadherin gamma-C5
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PCDGM_HUMAN » Protocadherin gamma-C5 » PCDH-gamma-C5;
Hydrophobic Thickness 33.8 ± 1.8 Å
Tilt Angle 3 ± 2°
ΔGtransfer -22.7 kcal/mol
ΔGfold -20.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 690-712 (689-715)
Pathways none
PDB none
OPM none
Complexes none
Interactions

A4, Complex: PCDGM:A4, PubMed

Domains

AA: 30-112, PDBID: 4ZPN, Subunit A, Seq Identity:95%, Cadherin-like

AA: 138-233, PDBID: 4ZPN, Subunit B, Seq Identity:95%, Cadherin domain

AA: 247-341, PDBID: 4ZPN, Subunit B, Seq Identity:89%, Cadherin domain

AA: 357-445, PDBID: 4ZPL, Subunit A, Seq Identity:33%, Cadherin domain

AA: 459-555, PDBID: 4ZPL, Subunit A, Seq Identity:31%, Cadherin domain

AA: 577-667, PDBID: 4ZPL, Subunit A, Seq Identity:33%, Cadherin domain

AA: 689-791, Cadherin cytoplasmic C-terminal

AA: 822-944, Cadherin C-terminal cytoplasmic tail, catenin-binding region

UniProt annotation for PCDGM_HUMAN » Protocadherin gamma-C5
FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
UniProt features for PCDGM_HUMAN » Protocadherin gamma-C5
SIGNAL 1 29 Potential.
CHAIN 30 944 Protocadherin gamma-C5.
DOMAIN 30 133 Cadherin 1.
DOMAIN 134 242 Cadherin 2.
DOMAIN 243 350 Cadherin 3.
DOMAIN 351 454 Cadherin 4.
DOMAIN 455 564 Cadherin 5.
DOMAIN 571 677 Cadherin 6.
Amino Acid Sequence for PCDGM_HUMAN » Protocadherin gamma-C5
MGPKTLPQLA GKWQVLCMLS LCCWGWVSGQ LRYSVVEESE PGTLVGNVAQ DLGLKMTDLL SRRLQLGSEE NGRYFSLSLM SGALAVNQKI DRESLCGAST SCLLPVQVVT EHPLELIRVE VEILDLNDNS PSFATPEREM RISESAASGA RFPLDSAQDP DVGTNTVSFY TLSPNSHFSL NVKTLKDGKP FPELVLEQQL DREAQARHQL VLTAVDGGTP ARSGTTLISV IVLDINDNAP TFQSSVLRVG IPENAPIGTL LLRLNATDPD EGTNGQLDYS FGDHTSEAVR NLFGLDPSSG AIHVLGPIDF EESRFYEIHA RARDQGQPAM EGHCVIQVDV GDVNDNAPEV LLASLANPVL ESTPVGTVVG LFNVRDRDSG RNGEVSLDIS PDLPFQIKPS ENHYSLLTSQ PLDREATSHY IIELLASDAG SPSLHKHLTI RLNISDVNDN APRFNQQLYT AYILENRPPG SLLCTVAASD PDTGDNARLT YSIVGNQVQG APASSFVYVN PEDGRIFAQR TFDYELLQML QIVVGVRDSG SPPLHANTSL HVFVLDENDN APAVLHPRPD WEHSAPQRLP RSAPPGSLVT KVTAVDADAG HNAWLSYSLL PQSTAPGLFL VSTHTGEVRT ARALLEDDSD TQQVVVLVRD NGDPSLSSTA TVLLVLEDED PEEMPKSSDF LIHPPERSDL TLYLIVALAT VSLLSLVTFT FLSAKCLQGN ADGDGGGGQC CRRQDSPSPD FYKQSSPNLQ VSSDGTLKYM EVTLRPTDSQ SHCYRTCFSP ASDGSDFTFL RPLSVQQPTA LALEPDAIRS RSNTLRERSQ QAPPNTDWRF SQAQRPGTSG SQNGDDTGTW PNNQFDTEML QAMILASASE AADGSSTLGG GAGTMGLSAR YGPQFTLQHV PDYRQNVYIP GSNATLTNAA GKRDGKAPAG GNGNKKKSGK KEKK